Expression of the CB1 cannabinoid receptor in macrophage-like cells from brain tissue: Immunochemical characterization by fusion protein antibodies

Journal of Neuroimmunology

Volumn 82, Issue 1, 1998, Pages 13-21

  Sinha, Debasish ^a,c   Bonner, Tom I ^b   Bhat, Narayan R ^a   Matsuda, Lisa A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c NATIONAL EYE INSTITUTE   (United States)

Author keywords

Cannabis; G protein coupled receptors; Marijuana; Microglia

Indexed keywords

CANNABINOID RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HYBRID PROTEIN;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; FEMALE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RABBIT; RECEPTOR DENSITY; TISSUE DISTRIBUTION;

ANIMALS; ANIMALS, NEWBORN; ANTIBODY SPECIFICITY; BRAIN; BRAIN CHEMISTRY; CANNABINOIDS; CHO CELLS; CRICETINAE; FEMALE; GENE EXPRESSION; GTP-BINDING PROTEINS; MACROPHAGES; MICROGLIA; RABBITS; RATS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; RECOMBINANT FUSION PROTEINS; SCHISTOSOMA JAPONICUM;

EID: 18544397160     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(97)00181-1     Document Type: Article

References (35)

1. Bhat N.R., Zhang P., Bhat A.N. Expression of MARCKS in oligodendrocytes is developmentally regulated. Dev. Neurosci. 17:1995;256-263.
2. Bouaboula M., Bourrie B., Rinaldi-Carmona M., Shire D., Le Fur G., Casellas P. Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells. J. Biol. Chem. 270(23):1995;13973-13980.
3. Bouaboula M., Rinaldi M., Carayon P., Carillon C., Deopech B., Shire D., Le fur G., Casellas P. Cannabinoid receptor-expression in human leukocytes. Eur. J. Biochem. 214(1):1993;173-180.
4. Chao C.C., Anderson W.R., Hu S., Gekher G., Martella A., Peterson P.K. Activated microglia inhibit multiplication of Taxoplasma gondii via a nitric oxide mechanism. Clin. Immunol. Immunopathol. 67:1993;178-183.
5. Chao C.C., Molitor T.W., Hu S. Neuroprotective role of IL-4 against activated microglia. J. Immunol. 151:1993;1473-1481.
6. Clements D.J., Cabral G.A., Mc Coy K.L. Delta-9 tetrahydrocannabinol selectively inhibits macrophage costimulatory activity and down regulates heat stable antigen expression. J. Pharmacol. Exp. Ther. 277(3):1996;1315-1321.
7. Coulter A., Harris R. Simplified preparation of rabbit Fab fragments. J. Immunol. Methods. 59:1983;199-203.
8. Derocq J., Segui M., Marchand J., Le Fur G., Casellas P. Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS Lett. 369:1995;177-182.
9. Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., Gibson D., Mandelbaum A., Etinger A., Mechoulam R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 258:1992;1946-1949.
10. Dewey W.L. Cannabinoid pharmacology. Pharmacol. Rev. 38:1986;151-178.
11. Pettit D.A., Showalter V.M., Abood M.E., Cabral G.A. Expression of a cannabinoid receptor in Baculovirus-infected insect cells. Biochem. Pharmacol. 48(6):1994;1231-1243.
12. Dickson D.W., Mattiace L.A., Kure K., Hutchins K., Lyman W.D., Brosnan C.F. Biology of disease. Microglia in human disease, with an emphasis on acquired immunodeficiency syndrome. Lab Invest. 64:1991;136-156.
13. Dubois-Dalcq M., Behar T., Hudson L., Lazzarini R.A. Emergence of three myelin proteins in oligodendrocytes cultured without neurons. J. Cell Biol. 102:1986;384-392.
14. Facci L., Dal Toso R., Romanello S., Buriani A., Skaper S.D., Leon A. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide. PNAS. 92:1995;3376-3380.
15. Felder C.C., Veluz J.S., Williams H.L., Briley E.M., Matsuda L.A. Cannabinoid agonists stimulate both receptor-and non-receptor mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones. Mol. Pharmacol. 42:1992;838-845.
16. Felder C.C., Joyce K.E., Briley E.M., Monsouri J., Mackie K., Blond O., Lai Y., Ma A.L., Mitchell R.L. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol. Pharmacol. 48:1995;443-450.
17. Galiegue S., Mary S., Marchand J., Dussossoy D., Carriene D., Carayon P., Bouaboula M., Shire D., Le Fur G., Casellas P. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur. J. Biochem. 232:1995;54-61.
18. Guilian D. Ameboid microglia as effectors of inflammation in the central nervous system. J. Neurosci. Res. 18:1987;155-171.
19. Hickey W.F., Kimura H. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science. 239:1988;290-292.
20. Howlett A.C., Qualy L.M., Khachatrian L.L. Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs. Mol. Pharmacol. 29:1986;307-313.
21. Kaminski N.E., Koh W.S., Yang K.H., Lee M., Kessler F.K. Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanisms. Biochem. Pharmacol. 48:1994;1899-1908.
22. Kawasaki, E.S., 1990. In: Innis, M.A., Gelfand, D.H., Snisky, J.J., White, T.J. (Eds.), PCR Protocols: A Guide to Methods and Applications. Academic Press, San Diego, CA, pp. 21-27.
23. Klein T.W., Newton C.A., Zhu W., Daaka Y., Friedman H. Delta-9-tetracannabinol, cytokines, and immunity to Legionella pneumophila. Proc. Soc. Exp. Biol. Med. 209:1995;205-212.
24. 4. Nature. 227:1970;680-685.
25. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.L. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
26. Matsuda L.A. Molecular aspects of cannabinoid receptors. Crit. Rev. Neurobiol. 11:1997;143-166.
27. Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of peripheral receptor for cannabinoids. Nature. 365:1993;61-65.
28. Ouchterlony O. Diffusion in gel methods for immunological analysis. Prog. Allergy. 5:1958;1.
29. Sedgwick J.D., Schwender S., Gregersen R., Dorries R., ter Meulen V. Resident macrophages (ramified microglia) of the adult brown Norway rat central nervous system are constitutively major histocompatibility complex class II positive. J. Exp. Med. 177:1993;1145.
30. Shivachar A.C., Martin B.R., Ellis E.F. Anandamide- and delta-9-tetrahydrocannabinol evoked arachidonic acid mobilization and blockade by Sr141716A. Biochem. Pharmacol. 51(5):1996;669-676.
31. Slipetz D.M., O'Neill G.P., Favreau L., Dufresne C., Gallant M., Gareau Y., Guay D., Labelle M., Metters K.M. Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Mol. Pharmacol. 48:1995;352-361.
32. Smith D.B., Johnson K.S. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene. 67:1988;31-40.
33. Song C., Howlett A.C. Rat brain cannabinoid receptors are N-linked glycosylated proteins. Life Sci. 56(23/24):1995;1983-1989.
34. Titishov N., Mechoulam R., Zimmerman A.M. Stereospecific effects of (-) and (+)-7-hydroxy-delta-6-tetrahydrocannabinol-dimethylheptyl on the immune system in mice. Pharmacology. 39:1989;337-349.
35. Watzl B., Scuderi P., Watson R.R. Marijuana components stimulate human peripheral blood mononuclear cell secretion of interferon-gamma and suppress interleukin-1 alpha in vitro. Int. J. Immunopharmacol. 13(8):1991;1091-1097.