Fate determinant expression in the lesioned brain: Olig2 induction and its implications for neuronal repair

Neurodegenerative Diseases

Volumn 4, Issue 4, 2007, Pages 328-332

  Buffo, Annalisa ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Amyloid; Focal ischemia; Glial precursors; Gliosis; Mouse neocortex; NG2; Pax6; Stab wound

Indexed keywords

HELIX LOOP HELIX PROTEIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR PAX6;

BRAIN; BRAIN DAMAGE; BRAIN INJURY; CELL ACTIVITY; CELL ISOLATION; CELL PROLIFERATION; GLIA CELL; HUMAN; MULTIPOTENT STEM CELL; NERVE REGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEUROBLAST; PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; UPREGULATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN INJURIES; GENE EXPRESSION; HUMANS; NERVE TISSUE PROTEINS; NEURONS; WOUND HEALING;

EID: 34347391303     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000101890     Document Type: Review

References (38)

1. Gage FH: Mammalian neural stem cells. Science 2000;287:1433-1438.
2. Lindvall OKZ, Martinez-Serrano A: Stem cell therapy for human neurodegenerative disorders - how to make it work. Nat Med 2004;10:S42-S50.
3. Palmer TD, Markakis EA, Willhoite AR, Safar F, Gage FH: Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 1999;19:8487-8497.
4. Weiss S, Dunne C, Hewson J, et al: Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J Neurosci 1996;16:7599-7609.
5. Tropepe V, Coles BL, Chiasson BJ, et al: Retinal stem cells in the adult mammalian eye. Science 2000;287:2032-2036.
6. Lie DC, Dziewczapolski G, Willhoite AR, Kaspar BK, Shults CW, Gage FH: The adult substantia nigra contains progenitor cells with neurogenic potential. J Neurosci 2002;22:6639-6649.
7. Yamamoto S, Yamamoto N, Kitamura T, Nakamura K, Nakafuku M: Proliferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord. Exp Neurol 2001;172:115-127.
8. Klein C, Butt SJB, Machold RP, Johnson JE, Fishell G: Cerebellum- and forebrain-derived stem cells possess intrinsic regional character. Development 2005;132:4497-4508.
9. Lee A, Kessler JD, Read T-A, et al: Isolation of neural stem cells from the postnatal cerebellum. Nat Neurosci 2005;8:723-729.
10. Nunes MC, Roy NS, Keyoung HM, et al: Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat Med 2003;9:439-447.
11. Horner PJ, Power AE, Kempermann G, et al: Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J Neurosci 2000;20:2218-2228.
12. Buffo A, Vosko MR, Erturk D, et al: Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc Natl Acad Sci USA 2005;102:18183-18188.
13. Alonso G: NG2 proteoglycan-expressing cells of the adult rat brain: possible involvement in the formation of glial scar astrocytes following stab wound. Glia 2005;49:318-338.
14. Laywell ED, Rakic P, Kukekov VG, Holland EC, Steindler DA: Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain. Proc Natl Acad Sci USA 2000;97:13883-13888.
15. Belachew S, Chittajallu R, Aguirre AA, et al: Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons. J Cell Biol 2003;161:169-186.
16. Kondo T, Raff M: Oligodendrocyte Precursor cells reprogrammed to become multipotential CNS stem cells. Science 2000;289:1754-1757.
17. Gensert JM, Goldman JE: In vivo characterization of endogenous proliferating cells in adult rat subcortical white matter. Glia 1996;17:39-51.
18. Yamamoto S-I, Nagao M, Sugimori M, et al: Transcription factor expression and notch-dependent regulation of neural progenitors in the adult rat spinal cord. J Neurosci 2001;21:9814-9823.
19. Hack MA, Saghatelyan A, de Chevigny A, et al: Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci 2005;8:865-872.
20. Parras C, Galli R, Britz O, et al: Mash1 specifies neurons and oligodendrocytes in the postnatal brain. EMBO J 2004;23:4495-4505.
21. Toresson H, Potter SS, Campbell K: Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2. Development 2000;127:4361-4371.
22. Ligon KL, Fancy SPJ, Franklin RJM, Rowitch DH: Olig gene function in CNS development and disease. Glia 2006;54:1-10.
23. Novitch BG, Chen AI, Jessell TM: Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 2001;31:773-789.
24. Lee S-K, Lee B, Ruiz EC, Pfaff SL: Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev 2005;19:282-294.
25. Rowitch DH, Lu QR, Kessaris N, Richardson WD: An 'oligarchy' rules neural development. Trends Neurosci 2002;25:417-422.
26. Takebayashi H, Yoshida S, Sugimori M, et al: Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech Dev 2000;99:143-148.
27. Fancy SPJ, Zhao C, Franklin RJM: Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS. Mol Cell Neurosci 2004;27:247-254.
28. Han SSW, Liu Y, Tyler-Polsz C, Rao MS, Fischer I: Transplantation of glial-restricted precursor cells into the adult spinal cord: survival, glial-specific differentiation, and preferential migration in white matter. Glia 2004;45:1-16.
29. Cassiani-Ingoni R, Coksaygan T, Xue H, et al: Cytoplasmic translocation of Olig2 in adult glial progenitors marks the generation of reactive astrocytes following autoimmune inflammation. Exp Neurol 2006;201:349-358.
30. Akiyama H, Barger S, Barnum S, et al: Inflammation and Alzheimer's disease. Neurobiol Aging 2000;21:383-421.
31. Liu Y, Rao MS: Glial progenitors in the CNS and possible lineage relationships among them. Biol Cell 2004;96:279-290.
32. Heins N, Malatesta P, Cecconi F, et al: Glial cells generate neurons: the role of the transcription factor Pax6. Nat Neurosci 2002;5:308-315.
33. Lim D, Tramontin A, Trevejo J, Herrera D, Garcia-Verdugo J, Alvarez-Buylla A: Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron 2000;28:713-726.
34. Setoguchi T, Yone K, Matsuoka E, et al: Traumatic injury-induced BMP7 expression in the adult rat spinal cord. Brain Res 2001;971:219-225.
35. Monje ML, Toda H, Palmer TD: Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003;302:1760-1765.
36. Ekdahl CT, Claasen J-H, Bonde S, Kokaia Z, Lindvall O: Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA 2003;100:13632-13637.
37. Zigova T, Pencea V, Wiegand SJ, Luskin MB: Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci 1998;11:234-245.
38. Pencea V, Bingaman KD, Wiegand SJ, Luskin MB: Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosci 2001;21:6706-6717.