Macrophages express granzyme B in the lesion areas of atherosclerosis and rheumatoid arthritis

Immunology Letters

Volumn 111, Issue 1, 2007, Pages 57-65

  Kim, Won Jung ^a   Kim, Ho ^a   Suk, Kyoungho ^b   Lee, Won Ha ^a  

^a Kyungpook National University   (South Korea)

^b Kyungpook National University School of Medicine   (South Korea)

Author keywords

Atherosclerosis; Granzyme B; Macrophage; Rheumatoid arthritis

Indexed keywords

GRANZYME B; PERFORIN; SCLEROPROTEIN;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL AGGREGATION; CONTROLLED STUDY; DISEASE COURSE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATORY DISEASE; MACROPHAGE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM;

ARTHRITIS, RHEUMATOID; ATHEROSCLEROSIS; CELL LINE; FLOW CYTOMETRY; GRANZYMES; HUMANS; IMMUNOHISTOCHEMISTRY; JOINTS; MACROPHAGES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 34347337475     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2007.05.004     Document Type: Article

References (31)

1. Krahenbuhl O., Rey C., Jenne D., Lanzavecchia A., Groscurth P., Carrel S., et al. Characterization of granzymes A and B isolated from granules of cloned human cytotoxic T lymphocytes. J Immunol 141 (1988) 3471-3477
2. Trapani J.A.S.M., Apostolidis V.A., Dawson M., and Browne K.A. Granule serine proteases are normal nuclear constituents of natural killer cells. J Biol Chem 269 (1994) 18359-18365
3. Andrade F.R.S., Nicholson D., Thornberry N., Rosen A., and Casciola-Rosen L. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity 8 (1998) 451-460
4. Sutton V.R.D.J., Cancilla M., Johnstone R.W., Ruefli A.A., Sedelies K., Browne K.A., et al. Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. J Exp Med 192 (2000) 1403-1414
5. Heibein J.A.G.I., Barry M., Pinkoski M.J., Shore G.C., Green D.R., and Bleackley R.C. Granzyme B-mediated cytochrome c release is regulated by the Bcl-2 family members bid and Bax. J Exp Med 192 (2000) 1391-1402
6. Simon M.M.K.M., Prester M., and Gay S. Mouse T-cell associated serine proteinase 1 degrades collagen type IV: a structural basis for the migration of lymphocytes through vascular basement membranes. Immunology 73 (1991) 117-119
7. Simon M.M.S.H., Fruth U., Epplen J., Muller-Hermelink H.K., and Kramer M.D. Cloned cytolytic T-effector cells and their malignant variants produce an extracellular matrix degrading trypsin-like serine proteinase. Immunology 60 (1987) 219-230
8. Sower L.E.K.G., Hanna W., and Froelich C.J. Extracellular activities of human granzymes. Cell Immunol 171 (1996) 159-163
9. Sower L.E.F.C., Allegretto N., Rose P.M., Hanna W.D., and Klimpel G.R. Extracellular activities of human granzyme A. Monocyte activation by granzyme A versus alpha-thrombin. J Immunol 156 (1996) 2585-2590
10. Lauw F.N.S.A., Hack C.E., Prins J.M., Wolbink A.M., van Deventer S.J., Chaowagul W., et al. Soluble granzymes are released during human endotoxemia and in patients with severe infection due to gram-negative bacteria. J Infect Dis 182 (2000) 206-213
11. Spaeny-Dekking E.H.H.W., Wolbink A.M., Wever P.C., Kummer A.J., Swaak A.J., Middeldorp J.M., et al. Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo. J Immunol 160 (1998) 3610-3616
12. Tak P.P.S.D.L., Kraan M.C., Breedveld F.C., Froelich C.J., and Hack C.E. The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA). Clin Exp Immunol 116 (1999) 366-370
13. Froelich C.J.Z.X., Turbov J., Hudig D., Winkler U., and Hanna W.L. Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes. J Immunol 151 (1993) 7161-7171
14. Ronday H.K., van der Laan W.H., Tak P.P., de Roos J.A., Bank R.A., TeKoppele J.M., et al. Human granzyme B mediates cartilage proteoglycan degradation and is expressed at the invasive front of the synovium in rheumatoid arthritis. Rheumatology (Oxford, England) 40 (2001) 55-61
15. Hirst C.E.B.M., Sutton V.R., Trapani J.A., Loveland K.L., and Bird P.I. Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction. Mol Hum Reprod 7 (2001) 1133-1142
16. Sasson R.D.A., Tajima K., and Amsterdam A. Novel genes modulated by FSH in normal and immortalized FSH-responsive cells: new insights into the mechanism of FSH action. FASEB J 17 (2003) 1256-1266
17. Hu S.X.W.S., Wang J.P., Mills G.B., Zhou Y., and Xu H.J. Expression of endogenous granzyme B in a subset of human primary breast carcinomas. Br J Cancer 89 (2003) 135-139
18. Horiuchi K.S.S., Sasaki R., Tomatsu T., and Toyama Y. Expression of granzyme B in human articular chondrocytes. J Rheumatol 30 (2003) 1799-1810
19. Rissoan M.C.D.T., Bridon J.M., Bendriss-Vermare N., Peronne C., de Saint Vis B., Briere F., et al. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood 100 (2002) 3295-3303
20. Held W.M.H., and Mueller C. Expression of genes encoding cytotoxic cell-associated serine proteases in thymocytes. Int Immunol 2 (1990) 57-62
21. Raja S.M.W.B., Dantuluri M., Desai U.R., Demeler B., Spiegel K., Metkar S.S., et al. Cytotoxic cell granule-mediated apoptosis, Characterization of the macromolecular complex of granzyme B with serglycin. J Biol Chem 277 (2002) 49523-49530
22. Bresnihan B. Pathogenesis of joint damage in rheumatoid arthritis. J Rheumatol 26 (1999) 717-719
23. Kinne R.W., Brauer R., Stuhlmuller B., Palombo-Kinne E., and Burmester G.R. Macrophages in rheumatoid arthritis. Arthritis Res 2 (2000) 189-202
24. Mulherin D., Fitzgerald O., and Bresnihan B. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum 39 (1996) 115-124
25. Yanni G., Whelan A., Feighery C., and Bresnihan B. Synovial tissue macrophages and joint erosion in rheumatoid arthritis. Ann Rheum Dis 53 (1994) 39-44
26. van Lent P.L., Holthuysen A.E., van den Bersselaar L.A., van Rooijen N., Joosten L.A., van de Loo F.A., et al. Phagocytic lining cells determine local expression of inflammation in type II collagen-induced arthritis. Arthritis Rheum 39 (1996) 1545-1555
27. Van Lent P.L., Holthuysen A.E., Van Rooijen N., Van De Putte L.B., and Van Den Berg W.B. Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis. Ann Rheum Dis 57 (1998) 408-413
28. Van Lent P.L., Van den Hoek A.E., Van den Bersselaar L.A., Spanjaards M.F., Van Rooijen N., Dijkstra C.D., et al. In vivo role of phagocytic synovial lining cells in onset of experimental arthritis. Am J Pathol 143 (1993) 1226-1237
29. Choy J.C., McDonald P.C., Suarez A.C., Hung V.H., Wilson J.E., McManus B.M., et al. Granzyme B in atherosclerosis and transplant vascular disease: association with cell death and atherosclerotic disease severity. Mod Pathol 16 (2003) 460-470
30. Smeets T.J., Kraan M.C., Galjaard S., Youssef P.P., Smith M.D., and Tak P.P. Analysis of the cell infiltrate and expression of matrix metalloproteinases and granzyme B in paired synovial biopsy specimens from the cartilage-pannus junction in patients with RA. Ann Rheum Dis 60 (2001) 561-565
31. Buzza M.S.Z.L., Sun J., Bird C.H., Smith A.I., Trapani J.A., Froelich C.J., et al. Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin. J Biol Chem 280 (2005) 23549-23558