Dissociation between the locomotor and anxiolytic effects of acetaldehyde in the elevated plus-maze: Evidence that acetaldehyde is not involved in the anxiolytic effects of ethanol in mice

European Neuropsychopharmacology

Volumn 15, Issue 6, 2005, Pages 655-662

  Tambour, Sophie ^a   Didone, Vincent ^a   Tirelli, Ezio ^a   Quertemont, Etienne ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Acetaldehyde; Anxiolysis; Cyanamide; Elevated plus maze; Ethanol

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALDEHYDE DEHYDROGENASE INHIBITOR; ANXIOLYTIC AGENT; CYANAMIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISSOCIATION; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; LOCOMOTION; MALE; MAZE TEST; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY;

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE; ANIMALS; ANTI-ANXIETY AGENTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYANAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ETHANOL; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MOTOR ACTIVITY; SPECIES SPECIFICITY;

EID: 27744504896     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2005.04.014     Document Type: Article

References (29)

1. M. Correa, M. Miquel, and C.M.G. Aragon Lead acetate potentiates brain catalase activity and enhances ethanol-induced locomotion in mice Pharmacol. Biochem. Behav. 66 2000 137 142
2. M. Correa, C. Sanchis-Segura, and C.M.G. Aragon Brain catalase activity is highly correlated with ethanol-induced locomotor activity in mice Physiol. Behav. 73 2001 641 647
3. M. Correa, M.N. Arizzi, A. Betz, S. Mingote, and J.D. Salamone Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate Brain Res. Bull. 62 2003 197 202
4. J.C. Crabbe, N.A. Johnson, D.K. Gray, A. Kosobud, and E.R. Young Biphasic effects of ethanol on open-field activity: sensitivity and tolerance in C57BL/6N and DBA/2N mice J. Comp. Physiol. Psychol. 96 1982 440 451
5. G.R. Dawson, and M.D. Tricklebank Use of the elevated plus-maze in the search for novel anxiolytic agents Trends Pharmacol. Sci. 16 1995 33 36
6. B.C. Dudek, T.J. Phillips, and M.E. Hahn Genetic analysis of the biphasic nature of the alcohol dose response curve Alcohol., Clin. Exp. Res. 15 1991 262 269
7. M.J. Durcan, and R.G. Lister Time course of ethanol effects on locomotor activity, exploration and anxiety in mice Psychopharmacology 96 1988 67 72
8. D. Escarabajal, and C.M.G. Aragon The effect of cyanamide and 4-methylpyrazole on the ethanol-induced locomotor activity in mice Pharmacol. Biochem. Behav. 72 2002 389 395
9. M.D. Escarabajal, and C.M.G. Aragon The effect of cyanamide and 4-methylpyrazole on the ethanol-induced locomotor activity in mice Pharmacol. Biochem. Behav. 72 2003 389 395
10. G.D. Frye, and G.R. Breese An evaluation of the locomotor stimulating action of ethanol in rats and mice Psychopharmacology 75 1981 372 379
11. R.J. Hale, A.L. Johnston, and H.C. Becker Indomethacin does not antagonize the anxiolytic action of ethanol in the elevated-plus-maze Psychopharmacology 101 1990 203 207
12. S.G. Holtzman, and F.H. Schneider Comparison of acetaldehyde and ethanol: depression of motor activity in mice Life Sci. 14 1974 1243 1250
13. M. Jamal, K. Ameno, M. Kumihashi, S. Ameno, T. Kubota, W. Wang, and I. Ijiri Microdialysis for the determination of acetaldehyde and ethanol concentrations in the striatum of freely moving rats J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 798 2003 155 158
14. S. Liljequist, and K. Ossowska Genotypic differences in locomotor stimulation and dopaminergic activity following acute ethanol administration Eur. Neuropsychopharmacol. 4 1994 31 38
15. J.G. Linakis, and C.L. Cunningham Effects of concentration of ethanol injected intraperitoneally on taste aversion, body temperature, and activity Psychopharmacology 64 1979 61 65
16. R.G. Lister The use of the plus-maze to measure anxiety in the mouse Psychopharmacology 92 1987 180 185
17. H. Matsumoto, and Y. Fukui Pharmacokinetics of ethanol: a review of the methodology Addict. Biol. 7 2002 5 14
18. T. Maurice, M. Casalino, M. Lacroix, and P. Romieu Involvement of the sigma 1 receptor in the motivational effects of ethanol in mice Pharmacol. Biochem. Behav. 74 2003 869 876
19. W.J. Mc Bride, T.K. Li, R.A. Deitrich, S. Zimatkin, B.R. Smith, and Z.A. Rodd-Henricks Involvement of acetaldehyde in alcohol addiction Alcohol., Clin. Exp. Res. 26 2002 114 119
20. L.D. Middaugh, W.O. Boggan, and C.L. Randall Stimulatory effects of ethanol in C57BL/6 mice Pharmacol. Biochem. Behav. 27 1987 421 424
21. W.D. Myers, S. Gibson, K.T. Ng, and G. Singer Sex differences in acetaldehyde on body temperature and open-field performance in the rat Drug Alcohol Depend. 19 1987 1 6
22. E. Quertemont Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism Mol. Psychiatry 9 2004 570 581
23. E. Quertemont, and S. Tambour Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol Trends Pharmacol. Sci. 25 2004 130 135
24. E. Quertemont, H.L. Green, and K.A. Grant Brain ethanol concentrations and ethanol discrimination in rats: effects of dose and time Psychopharmacology 168 2003 262 270
25. E. Quertemont, S. Tambour, P. Bernaerts, S.M. Zimatkin, and E. Tirelli Behavioral characterization of acetaldehyde in C57BL/6J mice: locomotor, hypnotic, anxiolytic and amnesic effects Psychopharmacology 177 2004 84 92
26. C.L. Randall, J.A. Carpenter, D. Lester, and H.J. Friedman Ethanol-induced mouse strain differences in locomotor activity Pharmacol. Biochem. Behav. 3 1975 533 535
27. B. Tabakoff, and K. Kiianmaa Does tolerance develop to the activating, as well as the depressant, effects of ethanol? Pharmacol. Biochem. Behav. 17 1982 1073 1076
28. K.L. Williams, A.P. Ferko, E.J. Barbieri, and G.J. DiGregorio Glycine enhances the central depressant properties of ethanol in mice Pharmacol. Biochem. Behav. 50 1995 199 205
29. J.H. Zar Biostatistical Analysis 3rd edition 1996 Prentice Hall Upper Saddle River, NJ