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Volumn 25, Issue 3, 2004, Pages 130-134

Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; ACETALDEHYDE; ALCOHOL; ALCOHOL DEHYDROGENASE; CENTRAL STIMULANT AGENT; COCAINE; DISULFIRAM; DOPAMINE; HYPNOTIC AGENT; PRODRUG; SALSOLINOL;

EID: 1342306772     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2004.01.001     Document Type: Article
Times cited : (52)

References (30)
  • 1
    • 0036148691 scopus 로고    scopus 로고
    • Involvement of acetaldehyde in alcohol addiction
    • McBride W.J., et al. Involvement of acetaldehyde in alcohol addiction. Alcohol. Clin. Exp. Res. 26:2002;114-119.
    • (2002) Alcohol. Clin. Exp. Res. , vol.26 , pp. 114-119
    • McBride, W.J.1
  • 2
    • 0034996278 scopus 로고    scopus 로고
    • Conditioned stimulus preference after acetaldehyde but not ethanol injections
    • Quertemont E., De Witte P. Conditioned stimulus preference after acetaldehyde but not ethanol injections. Pharmacol. Biochem. Behav. 68:2001;449-454.
    • (2001) Pharmacol. Biochem. Behav. , vol.68 , pp. 449-454
    • Quertemont, E.1    De Witte, P.2
  • 3
    • 0036210032 scopus 로고    scopus 로고
    • The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats
    • Rodd-Henricks Z.A., et al. The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats. Pharmacol. Biochem. Behav. 72:2002;55-64.
    • (2002) Pharmacol. Biochem. Behav. , vol.72 , pp. 55-64
    • Rodd-Henricks, Z.A.1
  • 4
    • 0035989882 scopus 로고    scopus 로고
    • Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats
    • Tampier L., Quintanilla M.E. Effect of acetaldehyde on acute tolerance and ethanol consumption in drinker and nondrinker rats. J. Stud. Alcohol. 63:2002;257-262.
    • (2002) J. Stud. Alcohol , vol.63 , pp. 257-262
    • Tampier, L.1    Quintanilla, M.E.2
  • 5
    • 0036236566 scopus 로고    scopus 로고
    • Aversion to acetaldehyde: Differences in low-alcohol-drinking (UchA) and high-alcohol-drinking (UchB) rats
    • Quintanilla M.E., et al. Aversion to acetaldehyde: differences in low-alcohol-drinking (UchA) and high-alcohol-drinking (UchB) rats. Alcohol. 26:2002;69-74.
    • (2002) Alcohol , vol.26 , pp. 69-74
    • Quintanilla, M.E.1
  • 6
    • 0037679303 scopus 로고    scopus 로고
    • Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats
    • Escarabajal M.D., et al. Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats. Psychopharmacology (Berl.). 167:2003;130-136.
    • (2003) Psychopharmacology (Berl.) , vol.167 , pp. 130-136
    • Escarabajal, M.D.1
  • 7
    • 0036205976 scopus 로고    scopus 로고
    • Cocaine-induced suppression of saccharin intake: A model of drug-induced devaluation of natural rewards
    • Grigson P.S., Twining R.C. Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewards. Behav. Neurosci. 116:2002;321-333.
    • (2002) Behav. Neurosci. , vol.116 , pp. 321-333
    • Grigson, P.S.1    Twining, R.C.2
  • 8
    • 0037401509 scopus 로고    scopus 로고
    • Role of catalase in ethanol-induced conditioned taste aversion: A study with 3-amino-1,2,4-triazole
    • Quertemont E., et al. Role of catalase in ethanol-induced conditioned taste aversion: a study with 3-amino-1,2,4-triazole. Drug Alcohol Depend. 70:2003;77-83.
    • (2003) Drug Alcohol Depend. , vol.70 , pp. 77-83
    • Quertemont, E.1
  • 9
    • 0348234851 scopus 로고    scopus 로고
    • Locomotor stimulant effects of intraventricular injections of low doses of ethanol in rats: Acute and repeated administration
    • Correa M., et al. Locomotor stimulant effects of intraventricular injections of low doses of ethanol in rats: acute and repeated administration. Psychopharmacology (Berl.). 170:2003;368-375.
    • (2003) Psychopharmacology (Berl.) , vol.170 , pp. 368-375
    • Correa, M.1
  • 10
    • 0344945548 scopus 로고    scopus 로고
    • Behavioral effects of intraventricular injections of low doses of ethanol, acetaldehyde, and acetate in rats: Studies with low and high rate operant schedules
    • Arizzi M.N., et al. Behavioral effects of intraventricular injections of low doses of ethanol, acetaldehyde, and acetate in rats: studies with low and high rate operant schedules. Behav. Brain Res. 147:2003;203-210.
    • (2003) Behav. Brain Res. , vol.147 , pp. 203-210
    • Arizzi, M.N.1
  • 11
    • 0345862025 scopus 로고    scopus 로고
    • Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate
    • Correa M., et al. Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate. Brain Res. Bull. 62:2003;197-202.
    • (2003) Brain Res. Bull. , vol.62 , pp. 197-202
    • Correa, M.1
  • 12
    • 0034897609 scopus 로고    scopus 로고
    • Brain catalase activity is highly correlated with ethanol-induced locomotor activity in mice
    • Correa M., et al. Brain catalase activity is highly correlated with ethanol-induced locomotor activity in mice. Physiol. Behav. 73:2001;641-647.
    • (2001) Physiol. Behav. , vol.73 , pp. 641-647
    • Correa, M.1
  • 13
    • 0036202163 scopus 로고    scopus 로고
    • Concurrent administration of diethyldithiocarbamate and 4-methylpyrazole enhances ethanol-induced locomotor activity: The role of brain ALDH
    • Escarabajal M.D., Aragon C.M.G. Concurrent administration of diethyldithiocarbamate and 4-methylpyrazole enhances ethanol-induced locomotor activity: the role of brain ALDH. Psychopharmacology (Berl.). 160:2002;339-343.
    • (2002) Psychopharmacology (Berl.) , vol.160 , pp. 339-343
    • Escarabajal, M.D.1    Aragon, C.M.G.2
  • 15
    • 0036202080 scopus 로고    scopus 로고
    • The effect of cyanamide and 4-methylpyrazole on the ethanol-induced locomotor activity in mice
    • Escarabajal M.D., Aragon C.M.G. The effect of cyanamide and 4-methylpyrazole on the ethanol-induced locomotor activity in mice. Pharmacol. Biochem. Behav. 72:2002;389-395.
    • (2002) Pharmacol. Biochem. Behav. , vol.72 , pp. 389-395
    • Escarabajal, M.D.1    Aragon, C.M.G.2
  • 16
    • 0036182385 scopus 로고    scopus 로고
    • Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model
    • Nishiguchi M., et al. Different blood acetaldehyde concentration following ethanol administration in a newly developed high alcohol preference and low alcohol preference rat model. Alcohol Alcohol. 37:2002;9-12.
    • (2002) Alcohol Alcohol. , vol.37 , pp. 9-12
    • Nishiguchi, M.1
  • 17
    • 0036867509 scopus 로고    scopus 로고
    • Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity
    • Isse T., et al. Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity. Pharmacogenetics. 12:2002;621-626.
    • (2002) Pharmacogenetics , vol.12 , pp. 621-626
    • Isse, T.1
  • 18
    • 0032872033 scopus 로고    scopus 로고
    • Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians
    • Peng G.S., et al. Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Pharmacogenetics. 9:1999;463-476.
    • (1999) Pharmacogenetics , vol.9 , pp. 463-476
    • Peng, G.S.1
  • 19
    • 0034958548 scopus 로고    scopus 로고
    • Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. I: Studies in outbred animals
    • Zimatkin S.M., et al. Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. I: Studies in outbred animals. Alcohol. Clin. Exp. Res. 25:2001;976-981.
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 976-981
    • Zimatkin, S.M.1
  • 20
    • 0034952955 scopus 로고    scopus 로고
    • Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice
    • Zimatkin S.M., et al. Relationship of brain ethanol metabolism to the hypnotic effect of ethanol. II: Studies in selectively bred rats and mice. Alcohol. Clin. Exp. Res. 25:2001;982-988.
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 982-988
    • Zimatkin, S.M.1
  • 21
    • 0035998901 scopus 로고    scopus 로고
    • Role of acetaldehyde in the discriminative stimulus effects of ethanol
    • Quertemont E., Grant K.A. Role of acetaldehyde in the discriminative stimulus effects of ethanol. Alcohol. Clin. Exp. Res. 26:2002;812-817.
    • (2002) Alcohol. Clin. Exp. Res. , vol.26 , pp. 812-817
    • Quertemont, E.1    Grant, K.A.2
  • 22
    • 0042868844 scopus 로고    scopus 로고
    • Discriminative stimulus effects of ethanol with a conditioned taste aversion procedure: Lack of acetaldehyde substitution
    • Quertemont E. Discriminative stimulus effects of ethanol with a conditioned taste aversion procedure: lack of acetaldehyde substitution. Behav. Pharmacol. 14:2003;343-350.
    • (2003) Behav. Pharmacol. , vol.14 , pp. 343-350
    • Quertemont, E.1
  • 23
    • 0035196554 scopus 로고    scopus 로고
    • Does acetaldehyde mediate ethanol action in the central nervous system?
    • Mascia M.P., et al. Does acetaldehyde mediate ethanol action in the central nervous system? Alcohol. Clin. Exp. Res. 25:2001;1570-1575.
    • (2001) Alcohol. Clin. Exp. Res. , vol.25 , pp. 1570-1575
    • Mascia, M.P.1
  • 24
    • 0037010770 scopus 로고    scopus 로고
    • Nucleus accumbens shell and core dopamine: Differential role in behavior and addiction
    • Di Chiara G. Nucleus accumbens shell and core dopamine: differential role in behavior and addiction. Behav. Brain Res. 137:2002;75-114.
    • (2002) Behav. Brain Res. , vol.137 , pp. 75-114
    • Di Chiara, G.1
  • 25
    • 85030876320 scopus 로고    scopus 로고
    • Acetaldehyde increases dopaminergic neuronal activity in the VTA
    • in press
    • Foddai, M. et al. Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology (in press).
    • Neuropsychopharmacology
    • Foddai, M.1
  • 26
    • 0346154811 scopus 로고    scopus 로고
    • Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: Occurrence, metabolism and function in human brains
    • Naoi M., et al. Dopamine-derived salsolinol derivatives as endogenous monoamine oxidase inhibitors: occurrence, metabolism and function in human brains. Neurotoxicology. 25:2004;193-204.
    • (2004) Neurotoxicology , vol.25 , pp. 193-204
    • Naoi, M.1
  • 27
    • 0041662183 scopus 로고    scopus 로고
    • In vivo study of salsolinol produced by a high concentration of acetaldehyde in the striatum and nucleus accumbens of free-moving rats
    • Jamal M., et al. In vivo study of salsolinol produced by a high concentration of acetaldehyde in the striatum and nucleus accumbens of free-moving rats. Alcohol. Clin. Exp. Res. 27:2003;79S-84S.
    • (2003) Alcohol. Clin. Exp. Res. , vol.27
    • Jamal, M.1
  • 28
    • 0038366850 scopus 로고    scopus 로고
    • In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis
    • Jamal M., et al. In vivo formation of salsolinol induced by high acetaldehyde concentration in rat striatum employing microdialysis. Alcohol Alcohol. 38:2003;197-201.
    • (2003) Alcohol Alcohol. , vol.38 , pp. 197-201
    • Jamal, M.1
  • 29
    • 0037347119 scopus 로고    scopus 로고
    • Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats
    • Rodd Z.A., et al. Salsolinol produces reinforcing effects in the nucleus accumbens shell of alcohol-preferring (P) rats. Alcohol. Clin. Exp. Res. 27:2003;440-449.
    • (2003) Alcohol. Clin. Exp. Res. , vol.27 , pp. 440-449
    • Rodd, Z.A.1
  • 30
    • 0030889522 scopus 로고    scopus 로고
    • Acetaldehyde-induced changes in the monoamine and amino acid extracellular microdialysate content of the nucleus accumbens
    • Ward R.J., et al. Acetaldehyde-induced changes in the monoamine and amino acid extracellular microdialysate content of the nucleus accumbens. Neuropharmacology. 36:1997;225-232.
    • (1997) Neuropharmacology , vol.36 , pp. 225-232
    • Ward, R.J.1


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