High-throughput cytochrome P450 inhibition assays using laser diode thermal desorption-atmospheric pressure chemical ionization-tandem mass spectrometry

Analytical Chemistry

Volumn 79, Issue 12, 2007, Pages 4657-4665

  Wu, Jin ^a   Hughes, Christopher S ^a   Picard, Pierre ^b   Letarte, Sylvain ^b   Gaudreault, Mireille ^a   Lévesque, Jean François ^a   Nicoll Griffith, Deborah A ^a   Bateman, Kevin P ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b Phytronix Technologies Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL IONIZATION; CYTOCHROME P450; INCUBATION; REPRODUCIBILITY;

ATMOSPHERIC PRESSURE; BIOASSAY; DRUG PRODUCTS; IONIZATION; MASS SPECTROMETRY; PROTEINS;

SEMICONDUCTOR LASERS;

4' HYDROXYDICLOFENAC; 6BETA HYDROXYTESTOSTERONE; BUFURALOL; CLOZAPINE; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DESIPRAMINE; DEXTROMETHORPHAN; DEXTRORPHAN; DICLOFENAC; DICLOFENAC DERIVATIVE; DILTIAZEM; EQUILIN; FLUFENAMIC ACID; FLUTAMIDE; FLUVOXAMINE; GENISTEIN; IMIPRAMINE; KETOCONAZOLE; MICONAZOLE; MIFEPRISTONE; NIFEDIPINE; PARACETAMOL; PHENACETIN; STAINLESS STEEL; SULFAPHENAZOLE; TESTOSTERONE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZAFIRLUKAST;

ARTICLE; ATMOSPHERIC PRESSURE; DESORPTION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; LIQUID CHROMATOGRAPHY; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ACETAMINOPHEN; ATMOSPHERIC PRESSURE; BINDING, COMPETITIVE; BIOLOGICAL ASSAY; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DEXTRORPHAN; DICLOFENAC; ENZYME INHIBITORS; HYDROXYTESTOSTERONES; LASERS; PROTEIN ISOFORMS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 34347246703     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac070221o     Document Type: Article

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