Validation of a rapid microtiter plate assay to conduct cytochrome P450 2D6 enzyme inhibition studies

Drug Discovery Today

Volumn 3, Issue 10, 1998, Pages 466-470

  Palamanda, Jairam R ^a   Favreau, Leonard ^a   Lin, Chin Chung ^a   Nomeir, Amin A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; DEXTRORPHAN;

BIOASSAY; DRUG DEVELOPMENT; DRUG METABOLISM; DRUG SCREENING; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LIVER MICROSOME; SHORT SURVEY;

EID: 0031786592     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(98)01248-3     Document Type: Review

References (14)

1. Smith D.A., Ackland M.J., Jones B.C. Drug Discovery Today. 2:1997;479-486.
2. Guengerich F.P. J. Pharmacokinet. Biopharm. 24:1996;521-533.
3. Parkinson A. Toxicol. Pathol. 96:1996;45-57.
4. Guengerich F.P. Chem.-Biol. Interact. 106:1997;161-182.
5. Lin J.H., Lu A.Y. Pharmacol. Rev. 49:1997;403-449.
6. Berman J.et al. J. Med. Chem. 40:1997;827-829.
7. Olah T.V., McLoughlin D.A., Gilbert J.D. Rapid Commun. Mass Spectrom. 11:1997;17-23.
8. Rodrigues A.D. Biochem. Pharmacol. 48:1994;2147-2156.
9. Rodrigues A.D. Anal. Biochem. 219:1994;309-320.
10. Crespi C.L., Miller V.P. Anal. Biochem. 248:1997;188-190.
11. Chen Z.R., Somogyi A.A., Bochner F. Ther. Drug Monit. 12:1990;97-104.
12. Zanger U.M.et al. Biochemistry. 27:1988;5447-5454.
13. Rodrigues A.D., Roberts E.M. Drug Metab. Dispos. 25:1997;651-655.
14. Halliday R.C.et al. Br. J. Clin. Pharmacol. 40:1995;369-378.