Helicobacter bilis: Bacterial provocateur orchestrates host immune responses to commensal flora in a model of inflammatory bowel disease

Gut

Volumn 56, Issue 7, 2007, Pages 898-900

  Fox, J G ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G2A; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ANTIBODY RESPONSE; BACTERIAL FLORA; CYTOKINE PRODUCTION; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HELICOBACTER BILIS; HELICOBACTER HEPATICUS; HUMAN; IMMUNE RESPONSE; NONHUMAN; NOTE; PRIORITY JOURNAL;

ANIMALS; COLITIS; DISEASE MODELS, ANIMAL; GERM-FREE LIFE; HELICOBACTER; HELICOBACTER INFECTIONS; INFLAMMATORY BOWEL DISEASES; MICE; MICE, INBRED STRAINS; SYMBIOSIS;

EID: 34347229117     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2006.115428     Document Type: Note

References (36)

1. Xu J, Gordon JI. Inaugural article: honor thy symbionts. Proc Natl Acad Sci USA 2003;100:10452-9.
2. Schaedler RW, Orcutt RP. Gastrointestinal microflora. In: Foster HL, Small JD, Fox JG, eds. The mouse in biomedical research, III. New York: Academic Press, 1983:327-45.
3. Eckburg PB, Bik EM, Bernstein CN, et al. Diversity of the human intestinal microbial flora. Science 2005;308:1635-8.
4. Singer SM, Nash TE. The role of normal flora in Giardia lamblia infections in mice. J Infect Dis 2000;181:1510-12.
5. Steffen EK, Berg RD. Relationship between cecal population levels of indigenous bacteria and translocation to the mesenteric lymph nodes. Infect Immun 1983;39:1252-9.
6. Thompson GE. Control of intestinal flora in animals and humans: implications for toxicology and health. J Environ Pathol Toxicol 1978;1:113-23.
7. Wells CL, Maddaus MA, Reynolds CM, et al. Role of anaerobic flora in the translocation of aerobic and facultatively anaerobic intestinal bacteria. Infect Immun 1987;55:2689-94.
8. Savage DC, McAllister JS, Davis CP. Anaerobic bacteria on the mucosal epithelium of the murine large bowel. Infect Immun 1971;4:492-502.
9. Gill SR, Pop M, Deboy RT, et al. Metagenomic analysis of the human distal gut microbiome. Science 2006;312:1355-59.
10. Savage DC, Dubos R, Schaedler RW. The gastrointestinal epithelium and its autochthonous bacterial flora. J Exp Med 1968;127:67-76.
11. Schaedler RW, Dubos R, Costello R. Association of germfree mice with bacteria isolated from normal mice. J Exp Med 1965;122:77-82.
12. Baker DE. The commercial production of mice with a specified flora. Natl Cancer Inst Monogr 1966;20:161-6.
13. Gordon HA, Pesti L. The gnotobiotic animal as a tool in the study of host microbial relationships. Bacterial Rev 1971;35:390-429.
14. Orcutt RP, Gianni F, Judge R. Development of an "altered Schaedler flora" for NCI gnotobiotic rodents. Microecol Ther 1987;17:59.
15. Dewhirst FE, Chien CC, Paster BJ, et al. Phylogeny of the defined murine microbiota: altered Schaedler flora. Appl Environ Microbiol 1999;65:3287-92.
16. Sarma-Rupavtarm RB, Ge Z, Schauer DB, et al. Spatial distribution and stability of the eight microbial species of the altered Schaedler flora in the mouse gastrointestinal tract. Appl Environ Microbiol 2004;70:2791-800.
17. Fox JG, Dewhirst FE, Tully JG, et al. Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J Clin Microbiol 1994;32:1238-45.
18. Fox JG, Yan LL, Dewhirst FE, et al. Helicobacter bilis sp. nov., a novel Helicobacter species isolated from bile, livers, and intestines of aged, inbred mice. J Clin Microbiol 1995;33:445-54.
19. Cahill RJ, Foltz G, Fox JG, et al. Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect Immun 1997;65:3126-31.
20. Chin EY, Dangler CA, Fox JG, et al. Helicobacter hepaticus infection triggers inflammatory bowel disease in T cell receptor alphabeta mutant mice. Comp Med 2000;50:586-94.
21. Fox JG, Yan L, Shames B, et al. Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus. Infect Immun 1996;64:3673-81.
22. Shomer NH, Dangler CA, Schrenzel MD, et al. Helicobacter bilis-induced inflammatory bowel disease in SCID mice with defined flora. Infect Immun 1997;65:4858-64.
23. Jiang HQ, Kushnir N, Thurnheer MC, et al. Monoassociation of SCID mice with Helicobacter muridarum, but not four other enterics, provokes IBD upon receipt of T cells. Gastroenterology 2002;122:1346-54.
24. Rogers AB, Fox JG. Inflammation and cancer. I. Rodent models of infectious gastrointestinal and liver cancer. Am J Physiol Gastrointest Liver Physiol 2004;286:G361-6.
25. Jergens AE, Wilson-Welder J, Dom A, et al. Helicobacter bilis triggers persistent immune reactivity to antigens derived from the commensal bacteria in gnotobiotic C3H/HeN mice. Gut 2007;56:934- 40.
26. Brandwein SL, McCabe RP, Cong Y, et al. Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J Immunol 1997;159:44-52.
27. Robertson BR, O'Rourke JL, Neilan BA, et al. Mucispirillum schaedleri gen. nov., sp. nov., a spiral-shaped bacterium colonizing the mucus layer of the gastrointestinal tract of laboratory rodents. Int J Syst Evol Microbiol 2005;55:1199-204.
28. Kirchain S, Taylor N, Whary M, et al. Colonization of germ-free mice with Mucispirillum schaedleri, a spiral bacterium of the rodent intestinal tract. J Am Assoc Lab Anim Sci, 2006;45:128.
29. Niess JH, Brand S, Gu X, et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005;307:254-8.
30. Pena JA, Rogers AB, Ge Z, et al. Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice. Infect Immun 2005;73:912-20.
31. Ge Z, Feng Y, Whary MT, et al. Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect Immun 2005;73:3559-67.
32. Whary MT, Danon SJ, Feng Y, et al. Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora. Infect Immun 2006;74:6615-23.
33. Fox JG, Beck P, Dangler CA, et al. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nat Med 2000;6:536-42.
34. Lemke L, Whary M, Ge Z, et al. Concurrent Helicobacter bilis infection in C57BL/6 mice modulates systemic and gastric immune responses and attenuates gastric pathology associated with H pylori infection. 2007. Abstract DDW Washington, DC.
35. Pirzer U, Schonhaar A, Fleischer B, et al. Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease. Lancet 1991;338:1238-9.
36. Macpherson A, Khoo UY, Forgoes I, et al. Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 1996;38:365-75.