CoMFA based de novo design of pyridazine analogs as PTP1B inhibitors

Journal of Molecular Graphics and Modelling

Volumn 26, Issue 1, 2007, Pages 117-123

  Nair, Pramod C ^a   Sobhia, M Elizabeth ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

CoMFA; Insulin and leptin signaling; LeapFrog; Obesity; PTP1B; Type 2 diabetes

Indexed keywords

ALLERGIES; CRYSTAL STRUCTURE; DRUG DOSAGE; INSULIN; STATISTICAL METHODS;

BOOTSTRAPPING ANALYSIS; COMPARATIVE MOLECULAR FIELD ANALYSIS; CORRELATION COEFFICIENTS; OBESITY; PHARMACOPHORIC MODEL;

PYRIDINE;

PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; PYRIDAZINE DERIVATIVE;

ARTICLE; BOOTSTRAPPING; COMPARATIVE MOLECULAR FIELD ANALYSIS; DRUG DESIGN; ENZYME INHIBITOR INTERACTION; IC 50; INHIBITION KINETICS; MOLECULAR MODEL; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANIMALS; COMPUTER SIMULATION; COMPUTER-AIDED DESIGN; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; ELECTROSTATICS; ENZYME INHIBITORS; HUMANS; MICE; MODELS, MOLECULAR; PROTEIN-TYROSINE-PHOSPHATASE; PYRIDAZINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 34250898601     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2006.10.002     Document Type: Article

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