De novo design and synthesis of HIV-1 integrase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 9, 2004, Pages 2317-2333

  Makhija, Mahindra T ^a,c   Kasliwal, Rajesh T ^a   Kulkarni, Vithal M ^a   Neamati, Nouri ^b  

^a UNIVERSITY OF MUMBAI   (India)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CURTIN UNIVERSITY   (Australia)

Author keywords

AIDS; CoMFA; HIV 1 integrase; LeapFrog

Indexed keywords

1 (2 CHLOROBENZYL)INDOLE 2,3 DIONE; 1 (2 NITROBENZYL)INDOLE 2,3 DIONE; 1 (3 FURAN 2 YLACRYLOYL) 5 METHYL 2 PHENYL 1,2 DIHYDROPYRAZOL 3 ONE; 1 (4 BROMOBENZYL)INDOLE 2,3 DIONE; 1 (4 NITROBENZYL)INDOLE 2,3 DIONE; 1 (FURAN 2 CARBONYL) 5 METHYL 2 (3 NITROPHENYL) 1,2 DIHYDROPYRAZOL 3 ONE; 1 (FURAN 2 CARBONYL) 5 METHYL 2 PHENYL 1,2 DIHYDROPYRAZOL 3 ONE; 1 (QUINOLIN 8 YLMETHYL)INDOLE 2,3 DIONE; 2 (3 CHLOROPHENYL) 1 (FURAN 2 CARBONYL) 5 METHYL 1,2 DIHYDROPYRAZOL 3 ONE; 2 (3 CHLOROPHENYL) 5 METHYL 1,2 DIHYDROPYRAZOL 3 ONE; 2 (4 BROMO 2 FLUOROPHENYL) 1 (FURAN 2 CARBONYL) 5 METHYL 1,2 DIHYDROPYRAZOL 3 ONE; 2 (4 BROMO 2 FLUOROPHENYL) 5 METHYL 1,2 DIHYDROPYRAZOL 3 ONE; 2 CHLOROBENZYLBROMIDE; 2 NITROBENZYLBROMIDE; 3 CHLOROPHENYL HYDRAZINE; 3 NITROPHENYL HYDRAZINE; 4 BROMO 2 FLUOROPHENYL HYDRAZINE; 4 BROMOBENZYLBROMIDE; 4 NITROBENZYLBROMIDE; 4' BROMOMETHYLBIPHENYL 2 CARBONITRILE; 5 ([1,2,4]TRIAZOLE 1 SULFONYL)ISOQUINOLINE; 5 (N PROPYL)ISOQUINOLINE SULFONAMIDE; 5 [N (2 TRIFLUOROMETHYL)PHENYL]ISOQUINOLINE SULFONAMIDE; 5 [N (3 CHLORO 4 FLUORO)PHENYL]ISOQUINOLINE SULFONAMIDE; 5 METHYL 2 (3 NITROPHENYL) 1,2 DIHYDROPYRAZOL 3 ONE; 5 METHYL 2 PHENYL 1,2 DIHYDROPYRAZOL 3 ONE; 8 BROMOMETHYLQUINOLINE; INTEGRASE INHIBITOR; N (1,5 DIMETHYL 3 OXO 2 PHENYL 2,3 DIHYDRO 1H PYRAZOL 4 YL)FURAN 2 CARBOXAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; INHIBITION KINETICS; MOLECULE; STRUCTURE ANALYSIS;

HIV INTEGRASE INHIBITORS; HIV-1; LEAST-SQUARES ANALYSIS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SPECTRUM ANALYSIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 1842686769     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.02.005     Document Type: Article

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