From Tolerance to Autoimmunity: Is There a Risk in Early Life Vaccination?

Journal of Comparative Pathology

Volumn 137, Issue SUPPL. 1, 2007, Pages

  Goriely, S ^a   Goldman, M ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

autoimmunity; T helper cell; Toll like receptor; vaccine

Indexed keywords

ALPHA INTERFERON; AUTOANTIGEN; BACTERIAL DNA; BETA INTERFERON; CANCER VACCINE; CD4 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; DOUBLE STRANDED RNA; EPITOPE; FLAGELLIN; GAMMA INTERFERON; GLYCOPEPTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; LIPOPOLYSACCHARIDE; PHOSPHORYL LIPID A; RESIQUIMOD; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; VACCINE; WART VIRUS VACCINE;

ADAPTIVE IMMUNITY; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOSTIMULATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN INTERACTION; RISK ASSESSMENT; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; TIME; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; AUTOIMMUNITY; HUMANS; IMMUNE TOLERANCE; IMMUNITY, NATURAL; INFANT, NEWBORN; RISK FACTORS; T-LYMPHOCYTES, HELPER-INDUCER; TOLL-LIKE RECEPTORS; VACCINATION;

EID: 34250832811     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2007.04.013     Document Type: Article

References (27)

1. Aksoy E., Albarani V., Nguyen M., Laes J.F., Ruelle J.L., De Wit D., Willems F., Goldman M., and Goriely S. Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. Blood 109 (2007) 2887-2893
2. Batten M., Li J., Yi S., Kljavin N.M., Danilenko D.M., Lucas S., Lee J., de Sauvage F.J., and Ghilardi N. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nature Immunology 7 (2006) 929-936
3. Berland R., Fernandez L., Kari E., Han J.H., Lomakin I., Akira S., Wortis H.H., Kearney J.F., Ucci A.A., and Imanishi-Kari T. Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knock-in mice. Immunity 25 (2006) 429-440
4. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430 (2004) 257-263
5. Christensen S.R., Shupe J., Nickerson K., Kashgarian M., Flavell R.A., and Shlomchik M.J. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25 (2006) 417-428
6. Colgan J., and Rothman P. All in the family: IL-27 suppression of Th17 cells. Nature Immunology 7 (2006) 899-901
7. Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M., Lira S.A., Gorman D., Kastelein R.A., and Sedgwick J.D. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003) 744-748
8. De Wit D., Olislagers V., Goriely S., Vermeulen F., Wagner H., Goldman M., and Willems F. Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns. Blood 103 (2004) 1030-1032
9. Goldman M. Translational Mini-Review Series on Toll-like Receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders. Clinical and Experimental Immunology 147 (2007) 208-216
10. Goriely S., Molle C., Nguyen M., Albarani V., Ouled H.N., Lin R., De Wit D., Flamand V., Willems F., and Goldman M. Interferon regulatory factor 3 is involved in Toll-like receptor (TLR) 4- and TLR3-induced IL-12p35 gene activation. Blood 107 (2006) 1078-1084
11. Goriely S., Van Lint C., Dadkhah R., Libin M., De Wit D., Demonte D., Willems F., and Goldman M. A defect in nucleosome remodelling prevents IL-12(p35) gene transcription in neonatal dendritic cells. Journal of Experimental Medicine 199 (2004) 1011-1016
12. Goriely S., Vincart B., Stordeur P., Vekemans J., Willems F., Goldman M., and De Wit D. Deficient IL-12(p35) gene expression by dendritic cells derived from neonatal monocytes. Journal of Immunology 166 (2001) 2141-2146
13. Hue S., Ahern P., Buonocore S., Kullberg M.C., Cua D.J., McKenzie B.S., Powrie F., and Maloy K.J. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. Journal of Experimental Medicine 203 (2006) 2473-2483
14. Lang K.S., Georgiev P., Recher M., Navarini A.A., Bergthaler A., Heikenwalder M., Harris N.L., Junt T., Odermatt B., Clavien P.A., Pircher H., Akira S., Hengartner H., and Zinkernagel R.M. Immunoprivileged status of the liver is controlled by Toll-like receptor 3 signalling. Journal of Clinical Investigation 116 (2006) 2456-2463
15. Lang K.S., Recher M., Junt T., Navarini A.A., Harris N.L., Freigang S., Odermatt B., Conrad C., Ittner L.M., Bauer S., Luther S.A., Uematsu S., Akira S., Hengartner H., and Zinkernagel R.M. Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease. Nature Medicine 11 (2005) 138-145
16. Levy O., Suter E.E., Miller R.L., and Wessels M.R. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Blood 108 (2006) 1284-1290
17. Mensah-Brown E.P., Shahin A., Al Shamisi M., Wei X., and Lukic M.L. IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin. European Journal of Immunology 36 (2006) 216-223
18. Molle, C., Nguyen, M., Flamand, V., Trottein, F., De Wit, D., Willems, F., Goldman, M. and Goriely, S. (2007). Interleukin-27 synthesis induced by Toll-like receptor ligation critically depends on interferon regulatory factor 3. Journal of Immunology, submitted for publication.
19. + cells. Journal of Immunology 175 (2005) 959-966
20. Prinz M., Garbe F., Schmidt H., Mildner A., Gutcher I., Wolter K., Piesche M., Schroers R., Weiss E., Kirschning C.J., Rochford C.D., Bruck W., and Becher B. Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. Journal of Clinical Investigation 116 (2006) 456-464
21. Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., Villarino A.V., Huang Q., Yoshimura A., Sehy D., Saris C.J., O'Shea J.J., Hennighausen L., Ernst M., and Hunter C.A. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nature Immunology 7 (2006) 937-945
22. Takeda K., and Akira S. Toll-like receptors in innate immunity. International Immunology 17 (2005) 1-14
23. Vanden Eijnden S., Goriely S., De Wit D., Goldman M., and Willems F. Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns. European Journal of Immunology 36 (2006) 21-26
24. Vanden Eijnden S., Goriely S., De Wit D., Willems F., and Goldman M. IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in humans. European Journal of Immunology 35 (2005) 469-475
25. Waldner H., Collins M., and Kuchroo V.K. Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease. Journal of Clinical Investigation 113 (2004) 990-997
26. Weaver C.T., Harrington L.E., Mangan P.R., Gavrieli M., and Murphy K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24 (2006) 677-688
27. Wynn T.A. Th17: a giant step from Th1 and Th2. Nature Immunology 6 (2005) 1069-1070