The links between cellular Ca2+ and Na+/H+ exchange in the pathophysiology of essential hypertension

American Journal of Hypertension

Volumn 9, Issue 7, 1996, Pages 703-707

  Aviv, Abraham ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Calcium; calmodulin; hypertension; pH; serine theorine kinase; sodium hydrogen exchanger

Indexed keywords

CALCIUM; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN SERINE THREONINE KINASE; CALMODULIN; PROTEIN KINASE; SODIUM PROTON EXCHANGE PROTEIN;

BINDING SITE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL PH; ENZYME ACTIVITY; ENZYME BINDING; EPIDEMIOLOGICAL DATA; HUMAN; HYPERTENSION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; ENZYMOLOGY; METABOLISM; PATHOPHYSIOLOGY; PH; PHYSIOLOGY;

CALCIUM; CALMODULIN; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERTENSION; PROTEIN KINASES; SODIUM-HYDROGEN ANTIPORTER;

EID: 0030176777     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/0895-7061(95)00447-5     Document Type: Review

References (21)

1. 1. Rosskopf D, Dusing R, Siffert W: Membrane sodium-proton exchange and primary hypertension. Hypertension 1993;21:607-617.
2. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. Biochim Biophys Acta 1989; 988:73-97.
3. + exchangers. J Exp Biol 1994;196:337-345.
4. + exchanger isoforms. Am J Physiol (Cell Physiol 37) 1995; C283-C296.
5. + exchangers (NHE). Curr Opin Nephrol Hypertens 1993;2:708-714.
6. + antiport. J Biol Chem 1991; 266:15406-15413.
7. 2+ and protein kinase C. J Biol Chem 1990; 265:21068-21074.
8. 8. Nishizuka Y: The family of protein kinase C for signal transduction. JAMA 1989;262:1826-1833.
9. 9. Bell RM, Burns DJ: Lipid activation of protein kinase C. J Biol Chem 1991;266:4661-4664.
10. 2+ exchanger. J Biol Chem 1995;270:8996-9001.
11. + exchanger isoform 1 (NHE-1) is a novel member of the calmodulin-binding proteins. J Biol Chem 1994; 269:13703-13709
12. 2+ regulation-defective. J Biol Chem 1994;269:13710-13715.
13. 13. Carafoli E: Biogenesis: plasma membrane calcium ATPase: 15 years of work on the purified enzyme. FASEB J 1994;8:993-1002.
14. + as a candidate gene in human essential hypertension. Hypertension 1991;17:8-14.
15. + countertransport. J Am Soc Nephrol 1991;2:937-943.
16. 16. Rosskopf D, Fromter E, Siffert W: Hypertensive sodium-proton exchanger phenotype persists in immortalized lymphoblasts from essential hypertensive patients: a cell culture model for human hypertension. J Clin Invest 1993;92:2553-2559.
17. 2+ stores and cell responsiveness. Am J Physiol (Cell Physiol 33) 1993; 264:C1367-C1387.
18. 18. Grun-Fleckstein G, Thimm FF, Hofgartner TW, et al: Calcium overload - an important cellular mechanism in hypertension and arteriosclerosis. Drugs 1992; 44(suppl 1):23-30.
19. + antiporter phenotype, abundance, and phosphorylation of immortalized lymphoblasts from humans with hypertension. Hypertension 1995;25:971-977.
20. + exchange rate and more alkaline intracellular pH setpoint in essential hypertension: effects of protein kinase modulation in platelets. J Hypertens 1991;9:1013-1019.
21. + exchanger activity and NHE-1 mRNA expression in lymphocytes from patients with essential hypertension. Hypertension 1995;25:356-364.