Effect of Methylisobutyl Amiloride on [Na+]i, Reperfusion Arrhythmias, and Function in Ischemic Rat Hearts

Journal of Cardiovascular Pharmacology

Volumn 27, Issue 6, 1996, Pages 794-801

  Tani, Masato ^a   Shinmura, Ken ^a   Hasegawa, Hiroshi ^a   Nakamura, Yoshiro ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Intracellular Na+; Left ventricular function; Na+ Ca2+ exchange; Na+ H+ exchange; Reperfusion arrhythmias; Reperfusion injury

Indexed keywords

5 (N ISOBUTYL N METHYL)AMILORIDE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CREATINE PHOSPHATE; POTASSIUM ION; SODIUM ION;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART LEFT VENTRICLE DP-DT; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE METABOLISM; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HIGH ENERGY PHOSPHATE; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; REPERFUSION INJURY; SODIUM CALCIUM EXCHANGE; SODIUM CONDUCTANCE;

ADENOSINE TRIPHOSPHATE; AMILORIDE; ANIMALS; CALCIUM; HEART; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM-HYDROGEN ANTIPORTER; VENTRICULAR FUNCTION, LEFT;

EID: 0029898863     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199606000-00005     Document Type: Article

References (42)

1. Stephenson SE, Cole RK, Parrish TF, et al. Ventricular fibrillation during and after coronary artery occlusion: incidence and protection afforded by various drugs. Am J Cardiol 1960;5:77-89.
2. Corbalan R, Verrier RL, Lown B. Differing mechanisms for ventricular vulnerability during coronary artery occlusion and release. Am Heart J 1976;92:223-30.
3. Lee JA, Allen DG. Changes in intracellular free calcium concentration during long exposures to stimulated ischemia in isolated mammalian ventricular muscle. Circ Res 1992;71: 58-69.
4. 2+ overload and depressed recovery of ventricular function of reperfused ischemic rat hearts. Circ Res 1989;65:1045-56.
5. Opie LH. Reperfusion injury and its pharmacologic modification. Circulation 1989;80:1049-62.
6. Brooks WW, Verrier RL, Lown B. Protective effect of verapamil on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion. Cardiovasc Res 1980; 14:295-302.
7. Thandroyen FT. McCarthy J, Burton KP, Opie LH. Ryanodine and caffeine prevent ventricular arrhythmias during acute myocardial ischemia and reperfusion in rat heart. Circ Res 1988;62:306-14.
8. Tosaki A, Hearse DJ. Protective effect of transient calcium reduction against reperfusion-induced arrhythmias in rat hearts. Am J Physiol 1987;253:H225-33.
9. Ferrier GR, Moffat MP, Lukas A. Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion: studies on isolated canine ventricular tissues. Circ Res 1985;56:184-94.
10. 2+ regulating function of isolated rat heart. Cardiovasc Res 1996;31:263-9.
11. 2+ release from sarcoplasmic reticulum of rat heart. Am J Physiol 1996 (in press).
12. i recovery after global ischemia in the perfused heart. Circ Res 1993;72:993-1003.
13. Murphy E, Perlman M, London RE, Steenbergen C. Amiloride delays the ischemia-induced rise in cytosolic free calcium. Circ Res 1991;68:1250-8.
14. Tani M. Mechanisms of calcium overload in reperfused ischemic myocardium. Annu Rev Physiol 1990;52:543-59.
15. + exchange. Circ Res 1990; 66:1156-9.
16. + exchanger in reperfusion stunning in isolated perfused rat heart. J Cardiovasc Pharmacol 1993;22:877-83.
17. Duan J, Karmazyn M. Protective effects of amiloride on the ischemic reperfused rat heart. Relation to mitochondrial function. Eur J Pharmacol 1992;210:149-57.
18. Scholz W, Albus U, Counillon L, et al. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischemia and reperfusion. Cardiovasc Res 1995;29:260-8.
19. + exchange and reperfusion arrhythmias: protection by intracoronary infusion of a novel inhibitor. Am J Physiol 1994;267: H2430-40.
20. Walker MJA, Curtis MJ, Hearse DJ, et al. The Lambeth Conventions: guidelines for the study of arrhythmias in ischaemia, infarction, and reperfusion. Cardiovasc Res 1988;22: 447-55.
21. Taylor Z, Ng SL, Cragoe EJ Jr, Arruda JAL. Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters. Life Sci 1989:45:517-23.
22. Beremeyer HU. Methods in enzymatic analysis. New York: Academic Press, 1963:1404-8, 1777-9, 2102-10, 2129-31.
23. + buffering capacity but not their combination, attenuates myocardial stunning. Cardiovasc Res 1993;27:1645-50.
24. Opie LH, Coetzee WA. Role of calcium ions in reperfusion arrhythmias: relevance to pharmacologic intervention. Cardiovasc Drug Ther 1988;40:219-27.
25. 2+ exchange. Naunyn Schmiedebergs Arch Pharmacol 1991;344:220-4.
26. Garcia ML, King VF, Shevell JL, et al. Amilonde analogs inhibit L-type calcium channels and display calcium entry blocker activity. J Biol Chem 1990;265:3763-71.
27. Kleyman TR, Cragoe EJ Jr. Amiloride and its analogs as tools in the study of ion transport. J Membrane Biol 1988; 105:1-21.
28. Pierce GN, Cole WC, Liu K, et al. Modulation of cardiac performance by amiloride and several selected derivatives of amiloride. J Pharmacol Exp Ther 1993;265:1280-91.
29. Myers ML, Mathur S, Li G-H, Karmazyn M. Sodiumhydrogen exchange inhibitors improve postischemic recovery of function in the perfused rabbit heart. Cardiovasc Res 1995;29:209-14.
30. Bugge E, Ytrehus K. Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart - a protective additive to ischaemic preconditioning. Cardiovasc Res 1995;29:269-74.
31. + exchange inhibitor and its effects in cardiac ischaemia. Br J Pharmacol 1993;109:562-8.
32. + exchanger in reperfusion stunning in isolated perfused rat heart. J Cardiovasc Pharmacol 1993;22:877-83.
33. 2+ overload in isolated perfused rabbit heart. Circulation 1994;89:2787-98.
34. + antiporter inhibitor on postischemic reperfusion in pig heart. J Cardiovasc Pharmacol 1994;23:72-8.
35. Scholz W, Albus U, Counillon L, et al. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995;29:260-8.
36. Kihara Y, Grossman W, Morgan JP. Direct measurement of changes in intracellular calcium transients during hypoxia, ischemia, and reperfusion of intact mammalian heart. Circ Res 1989;65:1029-44.
37. McDonald TF, Hayashi H, Ponnambalm C, Watanabe T. Electrical activity and tension in guinea pig ventricular muscle during and after metabolic depression. In: Yamada K, Katz A.M., and Toyama J, eds. Cardiac function under ischaemia and hypoxia. Nagoya, Japan: The University of Nagoya Press, 1986:63-85.
38. Kihara Y, Morgan JP. Intracellular calcium and ventricular fibrillation: studies in the aequorin-loaded isovolumic ferret heart. Circ Res 1991;68:1378-89.
39. 2+ overload and improves function of reperfused ischemic hearts. Am J Physiol 1990;259:H354-61.
40. 2+ overload and impairs function in anoxic rat heart. J Mol Cell Cardiol 1990;22:57-72.
41. 31p-NMR studies. Basic Res Cardiol 1995;90:220-33.
42. Lazdunski M, Frelin C, Vigne P. The sodium/hydrogen exchange in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 1985;17: 1029-42.