Mice lacking two or all three selectins demonstrate overlapping and distinct functions for each selectin

Journal of Immunology

Volumn 162, Issue 11, 1999, Pages 6755-6762

  Jung, Unsu ^a,b   Ley, Klaus ^a,c  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; L SELECTIN; PADGEM PROTEIN; SELECTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; INFLAMMATION; INFLAMMATORY CELL; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MOUSE; MUTATION; NEUTROPHIL CHEMOTAXIS; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; SKIN INFECTION;

ANIMALS; CELL ADHESION; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; E-SELECTIN; FLOW CYTOMETRY; L-SELECTIN; LEUKOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; P-SELECTIN; RADIATION CHIMERA; SELECTINS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS AND INJURIES;

EID: 0033152580     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Arbones, M. L., D. C. Ord, K. Ley, H. Ratech, C. Maynard-Curry, G. Otten, D. J. Capon, and T. F. Tedder. 1994. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity 1:247.
2. Mayadas, T. N., R. C. Johnson, H. Rayburn, R. O. Hynes, and D. D. Wagner. 1993. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 74:541.
3. Labow, M. A., C. R. Norton, J. M. Rumberger, K. M. Lombard-Gillooly, D. J. Shuster, J. Hubbard, R. Bertko, P. A. Knaack, R. W. Terry, M. L. Harbison, F. Kontgen, C. L. Stewart, K. W. McIntyre, P. C. Will, D. K. Burns, and B. A. Wolitzky. 1994. Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity 1:709.
4. Tedder, T. F., D. A. Steeber, and P. Pizcueta. 1995. L-selectin deficient mice have impaired leukocyte recruitment into inflammatory sites. J. Exp. Med. 181:2259.
5. Ley, K., D. C. Bullard, M. L. Arbones, R. Bosse, D. Vestweber, T. F. Tedder, and A. L. Beaudet. 1995. Sequential contribution of L-and P-selectin to leukocyte rolling in vivo. J. Exp. Med. 181:669.
6. Kunkel, E. J., and K. Ley. 1996. Distinct phenotype of E-selectin deficient mice: E-selectin is required for slow leukocyte rolling in vivo. Circ. Res. 79:1196.
7. Jung, U., C. L. Ramos, D. C. Bullard, and K. Ley. 1998. Gene-targeted mice reveal the importance of L-selectin-dependent rolling for neutrophil adhesion. Am. J. Physiol. 274:H1785.
8. Bullard, D. C., E. J. Kunkel, H. Kubo, M. J. Hicks, I. Lorenzo, N. A. Doyle, C. M. Doerschuk, K. Ley, and A. L. Beaudet. 1996, Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med. 183:2329.
9. Kunkel, E. J., U. Jung, D. C. Bullard, K. E. Norman, B. A. Wolitzky, D. Vestweber, A. L. Beaudet, and K. Ley. 1996. Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule-1 (ICAM-1). J. Exp. Med. 183:57.
10. Ley, K., M. Allietta, D. C. Bullard, and S. J. Morgan. 1998. The importance of E-selectin for firm leukocyte adhesion in vivo. Circ. Res. 83:287.
11. Munoz, F. M., E. P. Hawkins, D. C. Bullard, A. L. Beaudet, and S. L. Kaplan. 1997. Host defense against infection with S. pneumoniae is impaired in E-, P-and E-/P-selectin deficient mice. J. Clin. Invest. 100:2099.
12. Frenette, P. S., T. N. Mayadas, H. Rayburn, R. O. Hynes, and D. D. Wagner. 1996. Susceptibility to infection and altered hematopoiesis in mice deficient in both P-and E-selectins. Cell 84:563.
13. Bosse, R., and D. Vestweber. 1994. Only simultaneous blocking of the L-and P-selectin completely inhibits neutrophil migration into mouse peritoneum. Eur. J. Immunol. 24:3019.
14. Jung, U., D. C. Bullard, T. F. Tedder, and K. Ley. 1996. Velocity difference between L-selectin and P-selectin dependent neutrophil rolling in venules of the mouse cremaster muscle in vivo. Am. J. Physiol. 271:H2740.
15. Lawrence, M. B., D. F. Bainton, and T. A. Springer. 1994. Neutrophil tethering to and rolling on E-selectin are separable by requirement for L-selectin. Immunity 1:137.
16. Alon, R., R. C. Fuhlbrigge, E. B. Finger, and T. A. Springer. 1996. Interactions through L-selectin between leukocytes and adherent leukocytes nucleate rolling adhesions on selectins and VCAM-1 in shear flow. J. Cell Biol. 135:849.
17. Luscinskas, F. W., H. Ding, P. Tan, D. Cumming, T. F. Tedder, and M. E. Gerritsen. 1996. L-and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-α-activated vascular endothelium under flow in vitro. J. Immunol. 157:326.
18. Lawrence, M. B., and T. A. Springer. 1991. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65:859.
19. Bullard, D. C., L. Qin, I. Lorenzo, W. M. Quinlin, N. A. Doyle, R. Bosse, D. Vestweber, C. M. Doerschuk, and A. L. Beaudet. 1995. P-selectin/ICAM-1 double mutant mice: acute emigration of neutrophils into the peritoneum is completely absent but is normal in pulmonary alveoli. J. Clin. Invest. 95:1782.
20. Norton, C. R., J. M. Rumberger, D. K. Burns, and B. A. Wolitzky. 1993. Characterization of murine E-selectin expression in vitro using novel anti-mouse E-selectin monoclonal antibodies. Biochem. Biophys. Res. Commun. 195:250.
21. 4-integrins in lymphocyte homing to mucosal tissues in vivo. J. Immunol. 152:3282.
22. Pries, A. R. 1988. A versatile video image analysis system for microcirculatory research. Int. J. Microcirc. Clin. Exp. 7:327.
23. Lipowsky, H. H., and B. W. Zweifach. 1978. Application of the "two-slit" photometric technique to the measurement of microvascular volumetric flow rates. Microvasc. Res. 15:93.
24. Reneman, R. S., B. Woldhuis, M. G. A. oude Egbrink, D. W. Slaaf, and G. J. Tangelder. 1992. Concentration and velocity profiles of blood cells in the microcirculation. In Advances in Cardiovascular Engineering. N. H. C. Hwang, V. T. Turitto, and M. R. T. Yen, eds. Plenum Press, New York, p. 25.
25. Frenette, P. S., S. Subbarao, I. B. Mazo, U. H. von Andrian, and D. D. Wagner. 1998. Endothelial selectins and vascular cell adhesion molecule-1 promote he-matopoieu'c progenitor homing to bone marrow. Proc. Natl. Acad. Sci. USA 95: 14423.
26. Dote, M., R. J. Korthuis, D. N. Granger, M. L. Entman, and C. W. Smith. 1993. P-selectin mediates spontaneous leukocyte rolling in vivo. Blood 82:1308.
27. Ley, K., A. Zakrzewicz, C. Hanski, L. M. Stoolman, and G. S. Kansas. 1995. Sialylated O-glycans and L-selectin sequentially mediate myeloid cell rolling in vivo. Blood 85:3727.
28. Jung, U., and K. Ley. 1997. Regulation of E-selectin, P-selectin and 1CAM-1 expression in mouse cremaster muscle vasculature. Microcirculation 4:311.
29. Ley, K., and P. Gaehtgens. 1991. Endothelial, not hemodynamic differences are responsible for preferential leukocyte rolling in venules. Circ. Res. 69:1034.
30. Steeber, D. A., M. A. Campbell, A. Basil, K. Ley, and T. F. Tedder. 1998. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Proc. Natl. Acad. Sci. USA 95:7562.
31. Jung, U., K. E. Norman, C. L. Ramos, K. Scharffetter-Kochanek, A. L. Beaudet, and K. Ley. 1998. Transit time of leukocytes rolling through venules controls cytokine-induced inflammatory cell recruitment in vivo. J. Clin. Invest. 102:1526.
32. Kubes, P., M. Jutila, and D. Payne. 1995. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J. Clin. Invest. 95:2510.
33. Etzioni, A., M. Frydman, S. Pollack, I. Avidor, M. L. Phillips, J. C. Paulson, and R. Gershoni-Baruch. 1993. Recurrent severe infections caused by a novel leukocyte adhesion deficiency. N. Engl. J. Med. 327:1789.
34. von Andrian, U. H., E. M. Berger, L. Ramezani, J. D. Chambers, H. D. Ochs, J. M. Harlan, J. C. Paulson, A. Etzioni, and K.-E. Arfors. 1993. In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes. J. Clin. Invest. 91:2893.
35. Jones, D. A., L. V. McIntire, C. W. Smith, and L. J. Picker. 1994. A two-step adhesion cascade for T cell/endothelial cell interactions under flow conditions. J. Clin. Invest. 94:2443.
36. Alon, R., P. D. Kassner, M. W. Carr, E. B. Finger, M. E. Hemler, and T. A. Springer. 1995. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell Biol. 128:1243.
37. Johnston, B., T. B. Issekutz, and P. Kubes. 1996. The 04 integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J. Exp. Med. 183:1995.
38. 7 integrals in formation of the gut-associated lymphoid tissue. Nature 382:366.
39. 7 integrins, and P-selectin in leukocyte rolling and adhesion in high endothelial venules of Peyer's patches. J. Immunol. 161:2449.
40. Frenette, P. S., C. Moyna, D. W. Hartwell, J. B. Lowe, R. O. Hynes, and D. D. Wagner. 1998. Platelet-endothelial interactions in inflamed mesenteric venules. Blood 91:1318.
41. Diacovo, T. G., K. D. Pun, R. A. Warnock, T. A. Springer, and U. H. von Andrian. 1996. Platelet-mediated lymphocyte delivery to high endothelial venules. Science 273:252.