Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants

Journal of Medicinal Chemistry

Volumn 45, Issue 26, 2002, Pages 5721-5726

  El Brollosy, Nasser R ^a   Jørgensen, Per T ^a   Dahan, Berit ^a   Boel, Anne Marie ^a   Pedersen, Erik B ^a   Nielsen, Claus ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

6 (3,5 DIMETHYLBENZYL) 5 ETHYL 1 (3 METHYLBUT 2 ENYLOXYMETHYL)URACIL; 6 (3,5 DIMETHYLBENZYL) 5 ETHYLURACIL DERIVATIVE; 6 BENZYL 1 (ETHOXYMETHYL) 5 ISOPROPYLURACIL; EMIVIRINE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT;

ANTI-HIV AGENTS; CELL LINE; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MUTATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL; VIRUS REPLICATION;

EID: 0037137588     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020949r     Document Type: Article

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