Ligand bridging of the DNA holliday junction: Molecular recognition of a stacked-X four-way junction by a small molecule

Angewandte Chemie - International Edition

Volumn 46, Issue 21, 2007, Pages 3850-3854

  Brogden, Anna L ^a   Hopcroft, Nicholas H ^a,c   Searcey, Mark ^b,d   Cardin, Christine J ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Bridging ligands; DNA structures; Ligand design; Structure elucidation; X ray diffraction

Indexed keywords

AMINES; BINDING SITES; CHROMOPHORES; LIGANDS; MOLECULAR RECOGNITION; X RAY DIFFRACTION;

BRIDGING LIGANDS; DNA STRUCTURES; HOLLIDAY JUNCTION; LIGAND DESIGN; STRUCTURE ELUCIDATION;

DNA;

ADENINE; CRUCIFORM DNA; LIGAND;

ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION;

ADENINE; BINDING SITES; DNA, CRUCIFORM; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION;

EID: 34250716392     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200603760     Document Type: Article

References (22)

1. R. Holliday, Genet. Res. 1964, 5, 282-304.
2. M. Ortiz-Lombardia, A. Gonzales, R. Eritja, J. Aymami, F. Azorin, M. Coll, Nat. Struct. Biol. 1999, 6, 913-917.
3. J. H. Thorpe, B. C. Gale, S. C. Teixeira, C. J. Cardin, J. Mol. Biol. 2003, 327, 97-109.
4. F. A. Hays, A. Teegarden, Z. J. Jones, M. Harms, D. Raup, J. Watson, E. Cavaliere, P. S. Ho, Proc. Natl. Acad. Sci. USA 2005, 102, 7157-7162.
5. B. F. Eichman, J. M. Vargason, B. H. M. Mooers, P. S. Ho, Proc. Natl. Acad. Sci. USA 2000, 97, 3971-3976.
6. F. A. Hays, V. Schirf, P. S. Ho, B. Demeler, Biochemistry 2006, 45, 2467-2471.
7. G. N. Parkinson, M. P. Lee, S. Neidle, Nature 2002, 417, 876-880.
8. J. Li, J. J. Correia, L. Wang, J. O. Trent, J. B. Chaires, Nucleic Acids Res. 2005, 33, 4649-4659.
9. H. E. Bryant, N. Schultz, H. D. Thomas, K. M. Parker, D. Flower, E. Lopez, S. Kyle, M. Meuth, N. J. Curtin, T. Helleday, Nature 2005, 434, 913-917.
10. H. M. Farmer, N. McCabe, C. J. Lord, A. N. J. Tutt, D. A. Johnson, T. B. Richardson, M. Santarosa, K. J. Dillon, I. Hickson, C. Knights, N. M. B. Martin, S. P. Jackson, G. C. M. Smith, A. Ashworth, Nature 2005, 434, 917-921.
11. M. A. Dunham, A. A. Neumann, C. L. Fasching, R. R. Reddel, Nat. Genet. 2000, 26, 447-450.
12. P. R. Laud, A. S. Multani, S. M. Bailey, L. Wu, J. Ma, C. Kingsley, M. Lebel, S. Pathak, R. Depinho, S. Chang, Genes Dev. 2005, 19, 2560-2570.
13. M. J. B. Moore, F. Cuenca, M. Searcey, S. Neidle, Org. Biomol. Chem. 2006, 4, 3479-3488.
14. A. Oleksi, A. G. Blanco, R. Boer, I. Uson, J. Aymami, A. Rodger, M. J. Hannon, M. Coll, Angew. Chem. 2006, 118, 1249-1253;
15. Angew. Chem. Int. Ed. 2006, 45, 1227-1231.
16. A. K. Todd, A. Adams, J. H. Thorpe, W. A. Denny, L. P. G. Wakelin, C. J. Cardin, J. Med. Chem. 1999, 42, 536-540.
17. J. H. Thorpe, J. R. Hobbs, A. K. Todd, W. A. Denny, P. Charlton, C. J. Cardin, Biochemistry 2000, 39, 15055-15061.
18. S. C. M. Teixeira, J. H. Thorpe, A. K. Todd, H. R. Powell, A. Adams, L. P. G. Wakelin, W. A. Denny, C. J. Cardin, J. Mol. Biol. 2002, 323, 167-171.
19. L. P. G. Wakelin, X. Bu, A. Eleftheriou, A. Parmar, C. Hayek, B. W. Stewart, J. Med. Chem. 2003, 46, 5790-5802.
20. K. V. Kepple, J. L. Boldt, A. M. Segall, Proc. Natl. Acad. Sci. USA 2005, 102, 6867-6872.
21. B. F. Eichman, B. H. M. Mooers, M. Alberti, J. E. Hearst, P. S. Ho, J. Mol. Biol. 2001, 308, 15-26.
22. H. P. Spielmann, T. J. Dwyer, J. E. Hearst, D. E. Wemmer, Biochemistry 1995, 34, 12937-12953.