Translational research in radiotherapy - Getting closer to the bedside

Radiotherapy and Oncology

Volumn 83, Issue 3, 2007, Pages 217-219

  Overgaard, Jens ^a   Baumann, Michael ^b,c,d  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b Department of Radiation Oncology ^*

^c Dresden Rossendorf   (Germany)

^d UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CONTROL; CANCER RADIOTHERAPY; CANCER RESEARCH; EDITORIAL; HUMAN; IMAGING SYSTEM; MEDICAL LITERATURE; PRIORITY JOURNAL; RADIATION PHYSICS; RADIOBIOLOGY; RADIOSENSITIVITY; TREATMENT PLANNING;

BIOMEDICAL RESEARCH; HEALTH SERVICES RESEARCH; HUMANS; RADIATION ONCOLOGY; RADIOTHERAPY;

EID: 34250324308     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2007.06.001     Document Type: Editorial

References (41)

1. Overgaard J., and van der Kogel A. ESTRO-Wolfsberg a synergistic approach towards modern radiobiology. Radiother Oncol 76 (2005) 109-111
2. Lobrich M., and Jeggo P.A. The two edges of the ATM sword: co-operation between repair and checkpoint functions. Radiother Oncol 76 (2005) 112-118
3. Zgheib O., Huyen Y., DiTullio Jr. R.A., et al. ATM signaling and 53BP1. Radiother Oncol 76 (2005) 119-122
4. Neijenhuis S., Begg A.C., and Vens C. Radiosensitization by a dominant negative to DNA polymerase beta is DNA polymerase beta-independent and XRCC1-dependent. Radiother Oncol 76 (2005) 123-128
5. Seidler J., Durzok R., Brakebusch C., and Cordes N. Interactions of the integrin subunit beta 1A with protein kinase B/Akt, pl30Cas and paxillin contribute to regulation of radiation survival. Radiother Oncol 76 (2005) 129-134
6. Eriksen J.G., Alsner J., Steiniche T., and Overgaard J. The possible role of TP53 mutation status in the treatment of squamous cell carcinomas of the head and neck (HNSCC) with radiotherapy with different overall treatment times. Radiother Oncol 76 (2005) 135-142
7. Toulany M., Dittmann K., Kruger M., Baumann M., and Rodemann H.P. Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway. Radiother Oncol 76 (2005) 143-150
8. Eicheler W., Krause M., Hessel F., Zips D., and Baumann M. Kinetics of EGFR expression during fractionated irradiation varies between different human squamous cell carcinoma lines in nude mice. Radiother Oncol 76 (2005) 151-156
9. Dittmann K., Mayer C., and Rodemann H.P. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother Oncol 76 (2005) 157-161
10. Krause M., Ostermann G., Petersen C., et al. Decreased repopulation as well as increased reoxygenation contribute to the improvement in local control after targeting of the EGFR by C225 during fractionated irradiation. Radiother Oncol 76 (2005) 162-167
11. Meng A.X., Jalali F., Cuddihy A., Bristow R.G., et al. Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiother Oncol 76 (2005) 168-176
12. Koritzinsky M., Seigneuric R., Magagnin M.G., van den Beucken T., Lambin P., and Wouters B.G. The hypoxic proteome is influenced by gene-specific changes in mRNA translation. Radiother Oncol 76 (2005) 177-186
13. Sørensen B.S., Hao J., Overgaard J., et al. Influence of oxygen concentration and pH on expression of hypoxia induced genes. Radiother Oncol 76 (2005) 187-193
14. Troost E.G., Bussink J., Kaanders J.H., et al. Comparison of different methods of CAIX quantification in relation to hypoxia in three human head and neck tumor lines. Radiother Oncol 76 (2005) 194-199
15. Said H.M., Katzer A., Flentje M., and Vordermark D. Response of the plasma hypoxia marker osteopontin to in vitro hypoxia in human tumor cells. Radiother Oncol 76 (2005) 200-205
16. Yaromina A., Holscher T., Eicheler W., et al. Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?. Radiother Oncol 76 (2005) 206-212
17. Hoogsteen I.J., Peeters W.J., Marres H.A., et al. Erythropoietin receptor is not a surrogate marker for tumor hypoxia and does not correlate with survival in head and neck squamous cell carcinomas. Radiother Oncol 76 (2005) 213-218
18. Haydont V., Mathe D., Bourgier C., et al. Induction of CTGF by TGF-beta1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives. Radiother Oncol 76 (2005) 219-225
19. Bernier J., and Overgaard J. Bridging gaps in translational radiation oncology. Radiother Oncol 80 (2006) 109-111
20. Krause M., Zips D., Thames H.D., Kummermehr J., and Baumann M. Preclinical evaluation of molecular-targeted anticancer agents for radiotherapy. Radiother Oncol 80 (2006) 112-122
21. Nordsmark M., Loncaster J., Aquino-Parsons C., et al. The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study. Radiother Oncol 80 (2006) 123-131
22. Fyles A., Milosevic M., Pintilie M., et al. Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer. Radiother Oncol 80 (2006) 132-137
23. Durand R.E., and Aquino-Parsons C. The fate of hypoxic (pimonidazole-labelled) cells inhuman cervix tumours undergoing chemo-radiotherapy. Radiother Oncol 80 (2006) 138-142
24. De Schutter H., Barbe B., Spaepen M., et al. Microsatellite alterations in head and neck squamous cell carcinoma and relation to expression of pimonidazole, CA IX and GLUT-1. Radiother Oncol 80 (2006) 143-150
25. Thorwarih D., Eschmann S.M., Holzner F., Paulsen F., and Alber M. Combined uptake of[18F]FDG and [18F]FMISO correlates with radiation therapy outcome in head-and-neck cancer patients. Radiother Oncol 80 (2006) 151-156
26. Troost E.G., Laverman P., Kaanders J.H., et al. Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors. Radiother Oncol 80 (2006) 157-164
27. Lukacova S., Overgaard J., Alsner J., and Horsman M.R. Strain and tumour specific variations in the effect of hypoxia on osteopontin levels in experimental models. Radiother Oncol 80 (2006) 165-171
28. Debucquoy A., Goethals L., Geboes K., Roels S., Me Bride W.H., and Haustermans K. Molecular responses of rectal cancer to preoperative chemoradiation. Radiother Oncol 80 (2006) 172-177
29. Eke I., Sandfort V., Mischkus A., Baumann M., and Cordes N. Antiproliferative effects of EGFR tyrosine kinase inhibition and radiation-induced genotoxic injury are attenuated by adhesion to fibronectin. Radiother Oncol 80 (2006) 178-184
30. Raju U., Ariga H., Koto M., et al. Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases. Radiother Oncol 80 (2006) 185-191
31. Mason K.A., Neal R., Hunter N., Ariga H., Ang K., and Milas L. CpG oligodeoxynucleotides are potent enhancers of radio- and chemoresponses of murine tumors. Radiother Oncol 80 (2006) 192-198
32. Handrick R., Rubel A., Faltin H., Eibl H., Belka C., and Jendrossek V. Increased cytotoxicity of ionizing radiation in combination with membrane-targeted apoptosis modulators involves downregulation of protein kinase B/Akt-mediated survival-signaling. Radiother Oncol 80 (2006) 199-206
33. Vink S.R., Schellens J.H., Beijnen J.H., et al. Phase I and pharmacokinetic study of combined treatment with perifosine and radiation in patients with advanced solid tumours. Radiother Oncol 80 (2006) 207-213
34. Wissink E.H., Verbrugge I., Vink S.R., et al. TRAIL enhances efficacy of radiotherapy in ap53 mutant, Bcl-2 overexpressing lymphoid malignancy. Radiother Oncol 80 (2006) 214-222
35. Klokov D., MacPhail S.M., Banath J.P., Byrne J.P., and Olive P.L. Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays. Radiother Oncol 80 (2006) 223-229
36. Helland S., Johnsen H., Froyland C., et al. Radiation-induced effects on gene expression: an in vivo study on breast cancer. Radiother Oncol 80 (2006) 230-235
37. Zschenker O., Borgmann K., Streichert T., Meier I., Wrona A., and Dikomey E. Lymphoblastoid cell lines differing in p53 status show clear differences in basal gene expression with minor changes after irradiation. Radiother Oncol 80 (2006) 236-249
38. Jaal J., and Dorr W. Radiation-induced damage to mouse urothelial barrier. Radiother Oncol 80 (2006) 250-256
39. Korreman S.S., Pedersen A.N., Josipovic M., et al. Cardiac and pulmonary complication probabilities for breast cancer patients after routine end-inspiration gated radiotherapy. Radiother Oncol 80 (2006) 257-262
40. Steneker M., Lomax A., and Schneider U. Intensity modulated photon and proton therapy for the treatment of head and neck tumors. Radiother Oncol 80 (2006) 263-267
41. Cozzi L., Clivio A., Bauman G., et al. Comparison of advanced irradiation techniques with photons for benign intracranial tumours. Radiother Oncol 80 (2006) 268-273