Molecular responses of rectal cancer to preoperative chemoradiation

Radiotherapy and Oncology

Volumn 80, Issue 2, 2006, Pages 172-177

  Debucquoy, Annelies ^a   Goethals, Laurence ^a   Geboes, Karel ^a   Roels, Sarah ^a   Mc Bride, William H ^b   Haustermans, Karin ^a  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Predictive markers; Preoperative radiation; Rectal cancer

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2; FLUOROURACIL; INTERLEUKIN 6; KI 67 ANTIGEN; OSTEOPONTIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EVALUATION; FEMALE; HUMAN; MALE; MOLECULAR DYNAMICS; PHASE 2 CLINICAL TRIAL; PREDICTION; PREOPERATIVE RADIOTHERAPY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RECTUM CARCINOMA;

ADULT; AGED; CYCLOOXYGENASE 2; FEMALE; FLUOROURACIL; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; KI-67 ANTIGEN; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NEOADJUVANT THERAPY; OSTEOPONTIN; PREOPERATIVE CARE; PROGNOSIS; PYRAZOLES; RECTAL NEOPLASMS; SULFONAMIDES; TUMOR MARKERS, BIOLOGICAL;

EID: 33748034069     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2006.07.016     Document Type: Article

References (25)

1. Agrawal D., Chen T., Irby R., et al. Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst 94 (2002) 513-521
2. Brouazin-Jousseaume V., Guitton N., Legue F., and Chenal C. GSH level and IL-6 production increased in Sertoli cells and astrocytes after gamma irradiation. Anticancer Res 22 (2002) 257-262
3. Brown D.C., and Gatter K.C. Ki67 protein: the immaculate deception?. Histopathology 40 (2002) 2-11
4. Coppola D., Szabo M., Boulware D., et al. Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clin Cancer Res 10 (2004) 184-190
5. Diaz A., Chepenik K.P., Korn J.H., Reginato A.M., and Jimenez S.A. Differential regulation of cyclooxygenases 1 and 2 by interleukin-1 beta, tumor necrosis factor-alpha, and transforming growth factor-beta 1 in human lung fibroblasts. Exp Cell Res 241 (1998) 222-229
6. Dimberg J., Samuelsson A., Hugander A., and Soderkvist P. Differential expression of cyclooxygenase 2 in human colorectal cancer. Gut 45 (1999) 730-732
7. Kargman S., Charleson S., Cartwright M., et al. Characterization of Prostaglandin G/H synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. Gastroenterology 111 (1996) 445-454
8. Kimura T., Tanaka S., Haruma K., et al. Clinical significance of MUC1 and E-cadherin expression, cellular proliferation, and angiogenesis at the deepest invasive portion of colorectal cancer. Int J Oncol 16 (2000) 55-64
9. Kinoshita T., Ito H., and Miki C. Serum interleukin-6 level reflects the tumor proliferative activity in patients with colorectal carcinoma. Cancer 85 (1999) 2526-2531
10. Kyzer S., and Gordon P.H. Determination of proliferative activity in colorectal carcinoma using monoclonal antibody Ki67. Dis Colon Rectum 40 (1997) 322-325
11. Marquette C., Linard C., Galonnier M., et al. IL-1beta, TNFalpha and IL-6 induction in the rat brain after partial-body irradiation: role of vagal afferents. Int J Radiat Biol 79 (2003) 777-785
12. Matsumoto M., Sakao Y., and Akira S. Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line. Int Immunol 10 (1998) 1825-1835
13. Ofner D., Grothaus A., Riedmann B., et al. MIB1 in colorectal carcinomas: its evaluation by three different methods reveals lack of prognostic significance. Anal Cell Pathol 12 (1996) 61-70
14. Oldberg A., Franzen A., and Heinegard D. Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence. Proc Natl Acad Sci USA 83 (1986) 8819-8823
15. Palmqvist R., Sellberg P., Oberg A., et al. Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers. Br J Cancer 79 (1999) 577-581
16. Petersen S., Haroske G., Hellmich G., et al. COX-2 expression in rectal carcinoma: immunohistochemical pattern and clinical outcome. Anticancer Res 22 (2002) 1225-1230
17. Rangaswami H., Bulbule A., and Kundu G.C. Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol 16 (2006) 79-87
18. Smith F.M., Reynolds J.V., Kay E.W., et al. COX-2 overexpression in pretreatment biopsies predicts response of rectal cancers to neoadjuvant radiochemotherapy. Int J Radiat Oncol Biol Phys 64 (2006) 466-472
19. Tannapfel A., Nusslein S., Fietkau R., et al. Apoptosis, proliferation, bax, bcl-2 and p53 status prior to and after preoperative radiochemotherapy for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 41 (1998) 585-591
20. Tazawa R., Xu X.M., Wu K.K., and Wang L.H. Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem Biophys Res Commun 203 (1994) 190-199
21. Therasse P., Arbuck S.G., Eisenhauer E.A., et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92 (2000) 205-216
22. Trikha M., Corringham R., Klein B., and Rossi J.F. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res 9 (2003) 4653-4665
23. Willett C.G., Hagan M., Daley W., et al. Changes in tumor proliferation of rectal cancer induced by preoperative 5-fluorouracil and irradiation. Dis Colon Rectum 41 (1998) 62-67
24. Xi H., Baldus S.E., Warnecke-Eberz U., et al. High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer. Clin Cancer Res 11 (2005) 8341-8347
25. Zhang H., and Sun X.F. Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. Am J Gastroenterol 97 (2002) 1037-1041