Development of immunosensors using carbon nanotubes

Biotechnology Progress

Volumn 23, Issue 3, 2007, Pages 517-531

  Veetil, Jithesh V ^a   Ye, Kaiming ^a  

^a 3202 Bell Engineering Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON NANOTUBES; DIAGNOSIS; DISEASES; DRUG DELIVERY; ELECTRONIC PROPERTIES;

BIOAPPLICATIONS; BIOTERRORISM; REAL TIME DETECTION;

IMMUNOSENSORS;

ANTIBODY; CARBON NANOTUBE;

BIOLOGICAL MODEL; CHEMISTRY; GENETIC PROCEDURES; IMMUNOASSAY; METHODOLOGY; NANOTECHNOLOGY; REVIEW;

ANTIBODIES; BIOSENSING TECHNIQUES; IMMUNOASSAY; MODELS, IMMUNOLOGICAL; NANOTECHNOLOGY; NANOTUBES, CARBON;

AVES;

EID: 34250306406     PISSN: 87567938     EISSN: None     Source Type: Journal    
DOI: 10.1021/bp0602395     Document Type: Review

References (97)

1. Morgan, C.; Newman, D.; Price, C. Immunosensors: Technology and opportunities in laboratory medicine. Clin. Chem. 1996, 42, 193-209.
2. Kubitschko, S.; Brückner, T.; Pohl, S.; Oranth, N. Sensitivity enhancement of optical immunosensors with nanoparticles. Anal. Biochem. 1997, 253, 112-122.
3. Tang, D.; Yuan, R.; Chai, Y. Biochemical and immunochemical characterization of the antigen-antibody reaction on a non-toxic biomimetic interface immobilized red blood cells of crucian carp and gold nanoparticles. Biosens. Bioelectron. 2007, 22, 1116-1120.
4. Zhang, L.; Yuan, R.; Huang, X.; Chai, Y.; Tang, D.; Cao, S. A new label-free amperometric immunosensor for rubella vaccine. Anal. Bioanal. Chem. 2005, 381, 1036-1040.
5. Tang, H.; Chen, J.; Yao, S.; Nie, L.; Deng, G.; Kuang, Y. Amperometric glucose biosensor based on adsorption of glucose oxidase at platinum nanoparticle-modified carbon nanotube electrode. Anal. Biochem. 2004, 331, 89-97.
6. Li, G.; Liao, I.; Hu, G.; Ma, N.; Wu, P. Study of carbon nanotube modified biosensor for monitoring total cholesterol in blood. Biosens. Bioelectron. 2005, 20, 2140-2144.
7. Iijima, S. Helical microtubules of graphite carbon. Nature 1991, 354, 56-58.
8. Ebbesen, T. W.; Ajayan, P. M. Large scale synthesis of carbon nanotubes. Nature 1992, 358, 1021-1033.
9. Thess, A.; Lee, R.; Nikolaev, P.; Dai, H.; Petit, P.; Robert, J.; Xu, C.; Lee, Y. H.; Kim, S. G.; Rinzler, A. G.; Colbert, D. T.; Scuseria, G. E.; Tománek, D.; Fischer, J. E.; Smalley, R. E. Crystalline ropes of metallic carbon nanotubules. Science 1996, 273, 483-487.
10. Kuo, T. F.; Chi, C. C.; Lin, I. N. Synthesis of carbon nanotubes by laser ablation of graphites at room temperature. Jpn. J. Appl. Phys. 2001, 40, 7147-7150.
11. Varadan, V. K.; Xie, J. Large scale synthesis of multiwalled carbon nanotubes by microwave CVD. Smart Mater. Struct. 2002, 11, 610-616.
12. Ebbesen, T. W. Production and purification of carbon nanotubes. In Carbon Nanotubes: Preparation and Properties; Ebbesen, T. W., Ed.; CRC Press: Boca Raton, FL, 1997; pp 139-162.
13. Choi, W. B.; Cheong, B.-H.; Chae, S.; Bae, E.; Lee, J.-W.; Kim, J.-R.; Kim, J.-J. Carbon-nanotube-based nonvolatile memory with oxide-nitride-oxide film and nanoscale channel. Appl. Phys. Lett. 2003, 82, 275-277.
14. Choi, W. B.; Jin, Y. W.; Kim, H. Y.; Lee, S. J.; Yun, M. J.; Kang, J. H.; Choi, Y. S.; Park, N. S.; Lee, N. S.; Kim, J. M. Electrophoresis deposition of carbon nanotubes for triode-type field emission display. Appl. Phys. Lett. 2001, 78, 1547-1549.
15. Davis, J. J.; Green, M. L. H.; Hill, H. A. O.; Leung, Y. C.; Sadler, P. J.; Sloan, J.; Xavier, A. V.; Tsang, S. C. The immobilisation of proteins in carbon nanotubes. Inorg. Chim. Acta 1998, 272, 261-266.
16. Banerjee, S.; Kahn, M. G. C.; Wong, S. S. Rational chemical strategies for carbon nanotube functionalization. Chem. Eur. J. 2003, 9, 1898-1908.
17. Wang, Y.; Iqbal, Z.; Malhotra, S. V. Functionalization of carbon nanotubes with amines and enzymes. Chem. Phys. Lett. 2005, 402, 96-101.
18. Wang, J.; Musameh, M.; Lin, Y. Solubilization of carbon nanotubes by Nafion toward the preparation of amperometric biosensors. J. Am. Chem. Soc. 2003, 125, 2408-2409.
19. Tzeng, Y.; Huang, T. S.; Chen, Y. C.; Liu, C.; Liu, Y. K. Hydration properties of carbon nanotubes and their effects on electrical and bio-sensor applications. New Diamond Front. Carbon Technol. 2004, 14, 193-201.
20. Francisco Pompeo, D. R. Water solubilization of single-walled carbon nanotubes by functionalization with glucosamine. Nano Lett. 2002, 2, 369-373.
21. Georgakilas, V.; Tagmatarchis, N.; Pantarotto, D.; Bianco, A.; Briand, J.-P.; Prato, M. Amino acid functionalisation of water soluble carbon nanotubes. Chem. Commun. 2002, 3050-3051.
22. Hui Hu, B. Z.; Hamon, M. A.; Kamaras, K.; Itkis, M. E.; Haddon, T. C. Sidewall functionalization of single-walled carbon nanotubes by addition of dichlorocarbene. J. Am. Chem. Soc. 2003, 125, 14893-14900.
23. Holzinger, M.; Vostrowsky, O.; Hirsch, A.; Hennrich, F.; Kappes, M.; Weiss, R.; Jellen, F. Sidewall functionalization of carbon nanotubes. Angew. Chem., Int. Ed. 2001, 40, 4002-4005.
24. Bahr, J. L.; Yang, J.; Kosynkin, D. V.; Bronikowski, M. J.; Smalley, R. E.; Tour, J. M. Functionalization of carbon nanotubes by electrochemical reduction of aryl diazonium salts: a bucky paper electrode. J. Am. Chem. Soc. 2001, 123 (27), 6536-42.
25. Moore, V. C.; Strano, M. S.; Haroz, E. H.; Hauge, R. H.; Smalley, R. E. Individually suspended single-walled carbon nanotubes in various surfactants. Nano Lett. 2003, 3, 1379-1382.
26. Panhuis, M. i. h.; Salvador, C.; Franklin, E.; Chambers, G.; Fonseca, A.; Nagy, J. B.; Blau, W. J.; Minett, A. I. Characterization of specific interaction between functionalized carbon nanotubes and an enzyme. J. Nanosci. Nanotechnol. 2003, 3, 209-213.
27. Chen, J.; Liu, H.; Weimer, W. A.; Halls, M. D.; Waldeck, D. H.; Walker, G. C. Noncovalent engineering of carbon nanotube surfaces by rigid, functional conjugated polymers. J. Am. Chem. Soc. 2002, 124, 9034-9035.
28. Chen, R. J.; Zhang, Y.; Wang, D.; Dai, H. Noncovalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J. Am. Chem. Soc 2001, 123, 3838-3839.
29. Fei, B.; Lu, H.; Hu, Z.; Xin, J. H. Solubilization, purification and functionalization of carbon nanotubes using polyoxometalate. Nanotechnology 2006, 17, 1589-1593.
30. Star, A.; Steuerman, D. W.; Heath, J. R.; Stoddart, J. F. Starched carbon nanotubes. Angew. Chem., Int. Ed. 2002, 41, 2508-2512.
31. Kim, O. K.; Je, J.; Baldwin, J. W.; Kooi, S.; Pehrsson, P. E.; Buckley, L. J. Solubilization of single-wall carbon nanotubes by supramolecular encapsulation of helical amylose. J. Am. Chem. Soc. 2003, 125, 4426-4427.
32. Bandyopadhyaya, R.; Nativ-Roth, E.; Regev, O.; Yerushalmi-Rozen, R. Stabilization of individual carbon nanotubes in aqueous solutions. Nano Lett. 2002, 2, 25-28.
33. Chen, J.; Dyer, M. J.; Yu, M. F. Cyclodextrin-mediated soft cutting of single-walled carbon nanotubes. J. Am. Chem. Soc. 2001, 123, 6201-6202.
34. Dodziuk, H.; Ejchart, A.; Anczewski, W.; Ueda, H.; Krinichnaya, E.; Dolgonos, G.; Kutner, W. Water solubilization, determination of the number of different types of single-wall carbon nanotubes and their partial separation with respect to diameters by complexation with beta-cyclodextrin. Chem. Commun. (Cambridge) 2003, 8, 986-987.
35. Fu, K.; Sun, Y.-P. Dispersion and solubilization of carbon nanotubes. J. Nanosci. Nanotechnol. 2003, 3, 351-364.
36. Susan, S. Chemical functionalization of carbon nanotubes. J. Nanosci. Nanotechnol. 2002, 2 (2), 113-123.
37. Hirsch, A. Functionalization of single-walled carbon nanotubes. Angew. Chem., Int. Ed. 2002, 41, 1853-1859.
38. Kam, N. W. S.; Dai, H. Carbon nanotubes as intracellular protein transporters: generality and biological functionality. J. Am. Chem. Soc. 2005, 127, 6021-6026.
39. Karajanagi, S. S.; Vertegel, A. A.; Kane, R. S.; Dordick, J. S. Structure and function of enzymes adsorbed onto single-walled carbon nanotubes. Langmuir 2004, 20, 11594-11599.
40. Shim, M.; Wong Shi Kam, N.; Chen, R. J.; Li, Y.; Dai, H. Functionalization of carbon nanotubes for biocompatibility and biomolecular recognition. Nano Lett. 2002, 2, 285-288.
41. Lenihan, J. S.; Gavalas, V. G.; Wang, J.; Andrews, R.; Bachas, L. G. Protein immobilization on carbon nanotubes through a molecular adapter. J. Nanosci. Nanotechnol. 2004, 4, 600-604.
42. O'Connor, M.; Kim, S. N.; Killard, A. J.; Forster, R. J.; Smyth, M. R.; Papadimitrakopoulos, F.; Rusling, J. F. Mediated amperometric immunosensing using single walled carbon nanotube forests. Analyst 2004, 129, 1176-80.
43. Naguib, N. N.; Mueller, Y. M.; Bojczuk, P. M.; Rossi, M. P.; Katsikis, P. D.; Gogotsi, Y. Effect of carbon nanofibre structure on the binding of antibodies. Nanotechnology 2005, 16, 567-571.
44. Wang, S.; Humphreys, E. S.; Chung, S. Y.; Delduco, D. F.; Lustig, S. R.; Wang, H.; Parker, K. N.; Rizzo, N. W.; Subramoney, S.; Chiang, Y. M.; Jagota, A. Peptides with selective affinity for carbon nanotubes. Nat. Mater. 2003, 2, 196-200.
45. Erlanger, B. F.; Chen, B.-X.; Zhu, M.; Brus, L. Binding of an anti-fullerene IgG monoclonal antibody to single wall carbon nanotubes. Nano Lett. 2001, 1, 465-467.
46. Jiang, K.; Schadler, L. S.; Zhang, R. W. S. X.; Zhang, H.; Terrones, M. Protein immobilization on carbon nanotubes via a two-step process of diimide -activated amidation. J. Mater. Chem. 2004, 14, 37-39.
47. Yu, X.; Kim, S. N.; Papadimitrakopoulos, F.; Rusling, J. F. Protein immunosensor using single-wall carbon nanotube forests with electrochemical detection of enzyme labels. Mol. BioSyst. 2005, 1, 70-78.
48. Gooding, J. J.; Wibowo, R.; Liu, J.; Yang, W.; Losic, D.; Orbons, S.; Mearns, F. J.; Shapter, J. G.; Hibbert, D. B. Protein electrochemistry using aligned carbon nanotube arrays. J. Am. Chem. Soc. 2003, 125, 9006-9007.
49. Pantarotto, D.; Partidos, C. D.; Graff, R.; Hoebeke, J.; Briand, J. P.; Prato, M.; Bianco, A. Synthesis, structural characterization, and immunological properties of carbon nanotubes functionalized with peptides. J. Am. Chem. Soc. 2003, 125, 6160-6164.
50. Wohlstadter, J. N.; Wilbur, J. L.; Sigal, G. B.; Biebuyck, H. A.; Billadeau, M. A.; Dong, L.; Fischer, A. B.; Gudibande, S. R.; Jameison, S. H.; Kenten, J. H.; Leginus, J.; Leland, J. K.; Massey, R. J.; Wohlstadter, S. J. Carbon nanotube based biosensor. Adv. Mater. 2003, 15, 1184-1187.
51. Elkin, T.; Jiang, X.; Taylor, S.; Lin, Y.; Gu, L.; Yang, H.; Brown, J.; Collins, S.; Sun, Y. P. Immuno-carbon nanotubes and recognition of pathogens. ChemBioChem 2005, 6, 640-3.
52. Lin, Y.; Elkin, T.; Taylor, S.; Gu, L.; Chen, B.; Veca, L. M.; Zhou, B.; Yang, H.; Brown, J.; Joseph, R.; Jones, E.; Jiang, X.; Sun, Y.-P. Preparation, characterization, and evaluation of immuno carbon nanotubes. Microchim. Acta 2006, 152, 249-254.
53. Park, D. W.; Kim, Y. H.; Kim, B. S.; So, H. M.; Won, K.; Lee, J. O.; Kong, K. J.; Chang, H. Detection of tumor markers using single-walled carbon nanotube field effect transistors. J. Nanosci. Nanotechnol. 2006, 6, 3499-3502.
54. Okuno, J.; Maehashi, K.; Kerman, K.; Takamura, Y.; Matsumoto, K.; Tamiya, E. Label-free immunosensor for prostate-specific antigen based on single-walled carbon nanotube array-modified microelectrod.es. Biosens. Bioelectron. 2006, 22, 2377-2381.
55. Ostuni, E.; Chapman, R. G.; Holmlin, R. E.; Takayama, S.; Whitesides, G. M. A Survey of structure-property relationships of surfaces that resist the adsorption of proteins. Langmuir 2001, 17, 5605-5620.
56. Chen, R. J.; Bangsaruntip, S.; Drouvalakis, K. A.; Kam, N. W.; Shim, M.; Li, Y.; Kim, W.; Utz, P. J.; Dai, H. Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 4984-4989.
57. Ostuni, E.; Chapman, R. G.; Liang, M. N.; Meluleni, G.; Pier, G.; Ingber, D. E.; Whitesides, G. M. SAMs that resist protein adsorption and adhesion of bacterial and mammalian cells. Langmuir 2001, 17, 6336-6343.
58. Lee, S. W.; Laibinis, P. E. Protein-resistant coatings for glass and metal oxide surfaces derived from oligo(ethylene glycol)-terminated alkytrichlorosilanes. Biomaterials 1998, 19, 1669-1675.
59. Sirdeshmukh, R.; Teker, K.; Panchapakesan, B. In Functionalization of Carbon Nanotubes with Antibodies for Breast Cancer Detection Applications, Proceedings of international conference on MEMS, NANO and smart systems, ICMENS'04, Alberta, Canada, 2004; Alberta, Canada 2004, pp 48-53.
60. Xiaoli, C.; Guodong, L.; Yuehe, L. Biosensors based on carbon nanotubes/nickel hexacyanoferrate/glucose oxidase nanocomposites. J. Biomed. Nanotechnol. 2005, 1 (3), 320-327.
61. Guan, W.; Li, Y.; Chen, Y.; Zhang, X.; Hu, G. Glucose biosensor based on multi-wall carbon nanotubes and screen printed carbon electrodes. Biosens. Bioelectron. 2005, 21, 508-512.
62. Tang, H.; Chen, J.; Yao, S.; Nie, L.; Deng, G.; Kuang, Y. Amperometric glucose biosensor based on adsorption of glucose oxidase at platinum nanoparticle-modified carbon nanotube electrode. Anal. Biochem. 2004, 331, 89-97.
63. Lin, Y.; Lu, F.; Tu, Y.; Ren, Z. Glucose biosensors based on carbon nanotube nanoelectrode ensembles. Nano Lett. 2004, 4, 191-195.
64. Tans, S. J.; Vershueren, A. R. M.; Dekker, C. Room-temperature transisitor based on a single carbon nanotube. Nature 1998, 393, 49-52.
65. Jing, K.; Soh, H.; T.; Cassell, A. M.; Quate, C. F.; Hongjie, D. Synthesis of individual single-walled carbon nanotubes on patterned silicon wafers. Nature 1998, 395, 878-881.
66. Chen, R. J.; Choi, H. C.; Bangsaruntip, S.; Yenilmez, E.; Tang, X.; Wang, Q.; Chang, Y. L.; Dai, H. An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices. J. Am. Chem. Soc. 2004, 126, 1563-1568.
67. Byon, H. R.; Choi, H. C. Network single-walled carbon nanotube-field effect transistors (SWNT-FETs) with increased Schottky contact area for highly sensitive biosensor applications. J. Am. Chem. Soc. 2006, 128, 2188-2189.
68. 3 nanowires and carbon nanotubes. J. Am. Chem. Soc. 2005, 127, 12484-12485.
69. Bradley, K.; Briman, M.; Star, A.; Gruner, G. Charge transfer from adsorbed proteins. Nano Lett. 2004, 4, 253-256.
70. Maehashi, K.; Katsura, T.; Kerman, K.; Takamura, Y.; Matsumoto, K.; Tamiya, E. Label-free protein biosensor based on aptamer-modified carbon nanotube field-effect transistors. Anal. Chem. 2007, 79, 782-787.
71. Takeda, S.; Sbagyo, A.; Sakoda, Y.; Ishii, A.; Sawamura, M.; Sueoka, K.; Kida, H.; Mukasa, K.; Matsumoto, K. Application of carbon nanotubes for detecting anti-hemagglutinins based on antigen-antibody interaction. Biosens. Bioelectron. 2005, 21, 201-205.
72. Lin, Y.; Yantasee, W.; Wang, J. Carbon nanotubes (CNTs) for the development of electrochemical biosensors. Front. Biosci. 2005, 10, 492-505.
73. gong, K.; Y. Y.; Zhang, M.; Su, L.; Xiong, S.; Mao, L. Electrochemistry and electro anlayltical applications of carbon nanotubes: A review. Anal. Sci. 2005, 21, 1383-1393.
74. Ren, Z. F.; Huang, Z. P.; Xu, J. W.; Wang, J. H.; Siegal, M. P.; Provencio, P. N. Synthesis of large arrays of well-aligned carbon nanotubes on glass. Science 1998, 282, 1105-1107.
75. Teo, K. B. K.; Chhowalla, M.; Amaratunga, G. A. J.; Milne, W. I.; Hasko, D. G.; Pirio, G.; Legagneux, P.; Wyczisk, F.; Pribat, D. Uniform patterned growth of carbon nanotubes without surface carbon. Appl. Phys. Lett. 2001, 79, 1534-1536.
76. Dai, L.; Patil, A.; Gong, X.; Guo, Z.; Liu, L.; Liu, Y.; Daoben Zhu, Aligned nanotubes. ChemPhysChem 2003, 4, 1150-1169.
77. Yang, Y.; Huang, S.; He, H.; Mau, A. W. H.; Dai, L. Patterned growth of well-aligned carbon nanotubes: A photolithographic approach. J. Am. Chem. Soc. 1999, 121, 10832-10833.
78. Li, J.; Stevens, R.; Delzeit, L.; Ng, H. T.; Cassell, A.; Han, J.; Meyyappan, M. Electronic properties of multiwalled carbon nanotubes in an embedded vertical array. Appl. Phys. Lett. 2002, 81, 910-912.
79. Liu, Z.; Shen, Z.; Zhu, T.; Hou, S.; Ying, L. Organizing single-walled carbon nanotubes on gold using a wet chemical self-assembling technique. Langmuir 2000, 16, 3569-3573.
80. Patolsky, F.; Weizmann, Y.; Willner, I. Long-range electrical contacting of redox enzymes by SWCNT connectors. Angew. Chem., Int. Ed. 2004, 43, 2113-2117.
81. Sotiropoulou, S.; Chaniotakis, N. A. Carbon nanotube array-based biosensor. Anal. Bioanal. Chem. 2003, 375, 103-105.
82. Withey, G. D.; Lazareck, A. D.; Tzolov, M. B.; Yin, A.; Aich, P.; Yeh, J. I.; Xu, J. M. Ultra-high redox enzyme signal transduction using highly ordered carbon nanotube array electrodes. Biosens. Bioelectron. 2006, 21, 1560-1565.
83. Chattopadhyay, D.; Galeska, I.; Papadimitrakopoulos, F. Metal-assisted organization of shortened carbon nanotubes in monolayer and multilayer forest assemblies. J. Am. Chem. Soc. 2001, 123, 9451-9452.
84. Yu, X.; Kim, S. N.; Papadimitrakopoulos, F.; Rusling, J. F. Peroxidase activity of enzymes bound to the ends of single-wall carbon nanotube forest electrodes. Electrochem. Commmun. 2003, 5, 408-411.
85. Uda, T.; Kanmei, R.; Akasofu, S.; Hifumi, E.; Ohtaki, M. Application of polymer-protected ultrafine platinum particles to the immunological detection of human serum albumin. Anal. Biochem. 1994, 218, 259-264.
86. Poncharal, P.; Wang, Z. L.; Ugarte, D.; de Heer, W. Electrostatic deflections and electromechanical resonances of carbon nanotubes. Science 1999, 283, 1513-1516.
87. http://asaslab.mems.duke.edu/christian_research.htm (accessed on Feb 08, 2007),
88. Byon, H. R.; Hong, B. J.; Gho, Y. S.; Park, J. W.; Choi, H. C. Pseudo 3D single-walled carbon nanotube film for BSA-free protein chips. ChemBioChem 2005, 6, 1331-1334.
89. Nuraje, N.; Banerjee, I. A.; MacCuspie, R. I.; Yu, L.; Matsui, H. Biological bottom-up assembly of antibody nanotubes on patterned antigen arrays. J. Am. Chem. Soc. 2004, 126, 8088-8089.
90. Wang, J.; Liu, G.; Jan, M. Ultrasensitive electrical biosensing of proteins and DNA: Carbon nanotube derived amplification of the recognition and transduction events. J. Am. Chem. Soc. 2004, 126, 3010-3011.
91. Yu, X.; Munge, B.; Patel, V.; Jensen, G.; Bhirde, A.; Gong, J. D.; Kim, S. N.; Gillespie, J.; Gutkind, J. S.; Papadimitrakopoulos, F.; Rusling, J. F. Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. J. Am. Chem. Soc. 2006, 128, 11199-11205.
92. Ziegler, K. J. Developing implantable optical biosensors. Trends Biotechnol. 2005, 23, 440-444.
93. Barone, P. W.; Baik, S.; Heller, D. A.; Strano, M. S. Near-infrared optical sensors based on single-walled carbon nanotubes. Nat. Mater. 2005, 4 (1), 86-92.
94. Shvedova, A. A.; Castranova, V.; Kisin, E. R.; Schwegler-Berry, D.; Murray, A. R.; Gandelsman, V. Z.; Maynard, A.; Baron, P. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 2003, 66, 1909-1926.
95. Singh, R.; Pantarotto, D.; Lacerda, L.; Pastorin, G.; Klumpp, C.; Prato, M.; Bianco, A.; Kostarelos, K. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 3357-3362.
96. Takeda, S.; Sbagyo, A.; Sakoda, Y.; Ishii, A.; Sawamura, M.; Sueoka, K.; Kida, H.; Mukasa, K.; Matsumoto, K. Application of carbon nanotubes for detecting anti-hemagglutinins based on antigen-antibody interaction. Biosens. Bioelectron. 2005, 21, 201-205.
97. Bianco, A.; Wu, W.; Pastorin, G.; Klumpp, C. d.; Lacerda, L.; Partidos, C. D.; Kostarelos, K.; Prato, M. Carbon nanotube-based vectors for delivering immunotherapeutics and drugs. In Nanotechnologies for the Life Sciences: Nanomaterials for Medical Diagnosis and Therapy; Kumar, C. S. S. R., Ed.; Wiley-VCH: Weinheim, 2007; Vol. 10, pp 85-142.