Carboxyl Terminus of NKX2.5 Impairs its Interaction with p300

Journal of Molecular Biology

Volumn 370, Issue 5, 2007, Pages 976-992

  Li, Tao ^a   Li, Yan Ming ^a   Jia, Zhu Qing ^a   Chen, Ping ^a   Ma, Kang Tao ^a   Zhou, Chun Yan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

cardiac specific transcript factors; inhibitory C terminal domain; interaction domain; Nkx2.5; p300

Indexed keywords

ACYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H4; MUTANT PROTEIN; PROTEIN P300; TRANSCRIPTION FACTOR NKX2.5;

ACETYLATION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE DELETION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 34250205260     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.05.033     Document Type: Article

References (60)

1. Lyons I., Parsons L.M., Hartley L., Li R., Andrews J.E., Robb L., and Harvey R.P. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 13 (1995) 1654-1666
2. Jamali M., Rogerson P.J., Wilton S., and Skerjanc I.S. Nkx2-5 activity is essential for cardiomyogenesis. J. Biol. Chem. 276 (2001) 42252-42258
3. Toko H., Zhu W., Takimoto E., Shiojima I., Hiroi Y., Zou Y., et al. Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart. J. Biol. Chem. 277 (2002) 24735-24743
4. Akazawa H., and Komuro I. Cardiac transcription factor Csx/Nkx2-5: its role in cardiac development and diseases. Pharmacol. Ther. 107 (2005) 252-268
5. Reamon-Buettner S.M., and Borlak J. Somatic NKX2-5 mutations as a novel mechanism of disease in complex congenital heart disease. J. Med. Genet. 41 (2004) 684-690
6. Chen C.Y., and Schwartz R.J. Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5. J. Biol. Chem. 270 (1995) 15628-15633
7. Kasahara H., Usheva A., Ueyama T., Aoki H., Horikoshi N., and Izumo S. Characterization of homo- and heterodimerization of cardiac Csx/Nkx2.5 homeoprotein. J. Biol. Chem. 276 (2001) 4570-4580
8. Zaffran S., and Frasch M. The homeodomain of Tinman mediates homo- and heterodimerization of NK proteins. Biochem. Biophys. Res. Commun. 334 (2005) 361-369
9. Kasahara H., and Benson D.W. Biochemical analyses of eight NKX2.5 homeodomain missense mutations causing atrioventricular block and cardiac anomalies. Cardiovasc. Res. 64 (2004) 40-51
10. Kasahara H., and Izumo S. Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tissue-specifying homeobox gene product Csx/Nkx2.5. Mol. Cell Biol. 19 (1999) 526-536
11. Sepulveda J.L., Belaguli N., Nigam V., Chen C.Y., Nemer M., and Schwartz R.J. GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol. Cell Biol. 18 (1998) 3405-3415
12. Durocher D., Charron F., Warren R., Schwartz R.J., and Nemer M. The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 16 (1997) 5687-5696
13. Thattaliyath B.D., Firulli B.A., and Firulli A.B. The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial natriuretic peptide gene. J. Mol. Cell Cardiol. 34 (2002) 1335-1344
14. Hiroi Y., Kudoh S., Monzen K., Ikeda Y., Yazaki Y., Nagai R., and Komuro I. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nature Genet. 28 (2001) 276-280
15. Habets P.E., Moorman A.F., Clout D.E., van Roon M.A., Lingbeek M., van Lohuizen M., et al. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes Dev. 16 (2002) 1234-1246
16. Stennard F.A., Costa M.W., Elliott D.A., Rankin S., Haast S.J., Lai D., et al. Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev. Biol. 262 (2003) 206-224
17. Ganga M., Espinoza H.M., Cox C.J., Morton L., Hjalt T.A., Lee Y., and Amendt B.A. PITX2 isoform-specific regulation of atrial natriuretic factor expression: synergism and repression with Nkx2.5. J. Biol. Chem. 278 (2003) 22437-22445
18. Kim T.G., Chen J., Sadoshima J., and Lee Y. Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors. Mol. Cell Biol. 24 (2004) 10151-10160
19. Nishida W., Nakamura M., Mori S., Takahashi M., Ohkawa Y., Tadokoro S., et al. A triad of serum response factor and the GATA and NK families governs the transcription of smooth and cardiac muscle genes. J. Biol. Chem. 277 (2002) 7308-7317
20. Akazawa H., Kudoh S., Mochizuki N., Takekoshi N., Takano H., Nagai T., and Komuro I. A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5. J. Cell Biol. 164 (2004) 395-405
21. Choi C.Y., Lee Y.M., Kim Y.H., Park T., Jeon B.H., Schulz R.A., and Kim Y. The homeodomain transcription factor NK-4 acts as either a transcriptional activator or repressor and interacts with the p300 coactivator and the Groucho corepressor. J. Biol. Chem. 274 (1999) 31543-31552
22. Yao T.P., Oh S.P., Fuchs M., Zhou N.D., Ch'ng L.E., Newsome D., et al. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 93 (1998) 361-372
23. Hasegawa K., Meyers M.B., and Kitsis R.N. Transcriptional coactivator p300 stimulates cell type-specific gene expression in cardiac myocytes. J. Biol. Chem. 272 (1997) 20049-20054
24. Poizat C., Sartorelli V., Chung G., Kloner R.A., and Kedes L. Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Mol Cell Biol. 20 (2000) 8643-8654
25. Poizat C., Puri P.L., Bai Y., and Kedes L. Phosphorylation-dependent degradation of p300 by doxorubicin-activated p38 mitogen-activated protein kinase in cardiac cells. Mol. Cell Biol. 25 (2005) 2673-2687
26. Sartorelli V., Huang J., Hamamori Y., and Kedes L. Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol. Cell Biol. 17 (1997) 1010-1026
27. Slepak T.I., Webster K.A., Zang J., Prentice H., O'Dowd A., Hicks M.N., and Bishopric N.H. Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D. J. Biol. Chem. 276 (2001) 7575-7585
28. Dai Y.S., and Markham B.E. p300 functions as a coactivator of transcription factor GATA-4. J. Biol. Chem. 276 (2001) 37178-37185
29. Kakita T., Hasegawa K., Morimoto T., Kaburagi S., Wada H., and Sasayama S. p300 protein as a coactivator of GATA-5 in the transcription of cardiac-restricted atrial natriuretic factor gene. J. Biol. Chem. 274 (1999) 34096-34102
30. Dai Y.S., Cserjesi P., Markham B.E., and Molkentin J.D. The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. J. Biol. Chem. 277 (2002) 24390-24398
31. Gusterson R., Brar B., Faulkes D., Giordano A., Chrivia J., and Latchman D. The transcriptional co-activators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascade. J. Biol. Chem. 277 (2002) 2517-2524
32. Gusterson R.J., Jazrawi E., Adcock I.M., and Latchman D.S. The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. J. Biol. Chem. 278 (2003) 6838-6847
33. Yanazume T., Hasegawa K., Morimoto T., Kawamura T., Wada H., Matsumori A., et al. Cardiac p300 is involved in myocyte growth with decompensated heart failure. Mol. Cell Biol. 23 (2003) 3593-3606
34. Muhr J., Andersson E., Persson M., Jessell T.M., and Ericson J. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral neural tube. Cell 104 (2001) 861-873
35. Lassot I., Estrabaud E., Emiliani S., Benkirane M., Benarous R., and Margottin-Goguet F. p300 modulates ATF4 stability and transcriptional activity independently of its acetyltransferase domain. J. Biol. Chem. 280 (2005) 41537-41545
36. Hecht A., Vleminckx K., Stemmler M.P., van Roy F., and Kemler R. The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates. EMBO J. 19 (2000) 1839-1850
37. Gu W., Schneider J.W., Condorelli G., Kaushal S., Mahdavi V., and Nadal-Ginard B. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72 (1993) 309-324
38. Novitch B.G., Spicer D.B., Kim P.S., Cheung W.L., and Lassar A.B. pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation. Curr. Biol. 9 (1999) 449-459
39. Bhalla S.S., Robitaille L., and Nemer M. Cooperative activation by GATA-4 and YY1 of the cardiac B-type natriuretic peptide promoter. J. Biol. Chem. 276 (2001) 11439-11445
40. Fluck C.E., and Miller W.L. GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1. Mol. Endocrinol. 18 (2004) 1144-1157
41. McBride K., Charron F., Lefebvre C., and Nemer M. Interaction with GATA transcription factors provides a mechanism for cell-specific effects of c-Fos. Oncogene 22 (2003) 8403-8412
42. Clabby M.L., Robison T.A., Quigley H.F., Wilson D.B., and Kelly D.P. Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2. J. Biol. Chem. 278 (2003) 5760-5767
43. Yan C., Naltner A., Conkright J., and Ghaffari M. Protein-protein interaction of retinoic acid receptor alpha and thyroid transcription factor-1 in respiratory epithelial cells. J. Biol. Chem. 276 (2001) 21686-21691
44. Yi M., Tong G.X., Murry B., and Mendelson C.R. Role of CBP/p300 and SRC-1 in transcriptional regulation of the pulmonary surfactant protein-A (SP-A) gene by thyroid transcription factor-1 (TTF-1). J. Biol. Chem. 277 (2002) 2997-3005
45. Bachurski C.J., Yang G.H., Currier T.A., Gronostajski R.M., and Hong D. Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription. Mol. Cell Biol. 23 (2003) 9014-9024
46. Toonen R.F., Gowan S., and Bingle C.D. The lung enriched transcription factor TTF-1 and the ubiquitously expressed proteins Sp1 and Sp3 interact with elements located in the minimal promoter of the rat Clara cell secretory protein gene. Biochem. J. 316 (1996) 467-473
47. Abraham S.E., Lobo S., Yaciuk P., Wang H.G., and Moran E. p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes. Oncogene 8 (1993) 1639-1647
48. Dallas P.B., Yaciuk P., and Moran E. Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. J. Virol. 71 (1997) 1726-1731
49. De Luca A., Severino A., De Paolis P., Cottone G., De Luca L., De Falco M., et al. p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor. Biochem. J. 369 (2003) 477-484
50. Stanojevic V., Habener J.F., and Thomas M.K. Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300. Endocrinology 145 (2004) 2918-2928
51. Akazawa H., and Komuro I. Too much Csx/Nkx2-5 is as bad as too little?. J. Mol. Cell Cardiol. 35 (2003) 227-229
52. Monzen K., Zhu W., Kasai H., Hiroi Y., Hosoda T., Akazawa H., et al. Dual effects of the homeobox transcription factor csx/nkx2.5 on cardiomyocytes. Biochem. Biophys. Res. Commun. 298 (2002) 493-500
53. Zhu W., Shiojima I., Hiroi Y., Zou Y., Akazawa H., Mizukami M., et al. Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease. J. Biol. Chem. 275 (2000) 35291-35296
54. Martinez-Balbas M.A., Bauer U.M., Nielsen S.J., Brehm A., and Kouzarides T. Regulation of E2F1 activity by acetylation. EMBO J. 19 (2000) 662-671
55. Boyes J., Byfield P., Nakatani Y., and Ogryzko V. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396 (1998) 594-598
56. Yuan W., Condorelli G., Caruso M., Felsani A., and Giordano A. Human p300 protein is a coactivator for the transcription factor MyoD. J. Biol. Chem. 271 (1996) 9009-9013
57. Lee B.H., and Mathews M.B. Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein. Proc. Natl Acad. Sci. USA 94 (1997) 4481-4486
58. Harvey R.P. NK-2 homeobox genes and heart development. Dev. Biol. 178 (1996) 203-216
59. Teunissen B.E., van Amersfoorth S.C., Opthof T., Jongsma H.J., and Bierhuizen M.F. Sp1 and Sp3 activate the rat connexin40 proximal promoter. Biochem. Biophys. Res. Commun. 292 (2002) 71-78
60. Lee D., Hwang S.G., Kim J., and Choe J. Functional interaction between p/CAF and human papillomavirus E2 protein. J. Biol. Chem. 277 (2002) 6483-6489