RNase H-mediated retrovirus destruction in vivo triggered by oligodeoxynucleotides

Nature Biotechnology

Volumn 25, Issue 6, 2007, Pages 669-674

  Matzen, Kathrin ^a,b   Elzaouk, Lina ^a   Matskevich, Alexey A ^a   Nitzsche, Anja ^b   Heinrich, Jochen ^a   Moelling, Karin ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA SYNTHESIS; INFECTED CELLS; OLIGODEOXYNUCLEOTIDES; RETROVIRUS DESTRUCTION;

CELLS; DNA; MEDICAL PROBLEMS; PLASMA (HUMAN); VIRUSES;

OLIGONUCLEOTIDES;

OLIGODEOXYNUCLEOTIDE; OLIGODEOXYNUCLEOTIDE A; OLIGODEOXYNUCLEOTIDE M; PURINE DERIVATIVE; RIBONUCLEASE H; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONOTHERAPY; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SPECIFICITY; DRUG TARGETING; DRUG UPTAKE; EMBRYO; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REDUCTION KINETICS; RETROVIRUS; RETROVIRUS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM; SPLEEN FOCUS FORMING VIRUS; SURVIVAL RATE; VIRUS INHIBITION; VIRUS LOAD; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS TITRATION;

ANIMALS; GENE SILENCING; GENE TARGETING; HIV INFECTIONS; HIV-1; MICE; NIH 3T3 CELLS; RETROVIRIDAE; RIBONUCLEASE H, CALF THYMUS;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS; SPLEEN FOCUS-FORMING VIRUS;

EID: 34250159115     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1311     Document Type: Article

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