APC Inactivation Associates With Abnormal Mitosis Completion and Concomitant BUB1B/MAD2L1 Up-Regulation

Gastroenterology

Volumn 132, Issue 7, 2007, Pages 2448-2458

  Abal, Miguel ^a,h   Obrador Hevia, Antonia ^b   Janssen, Klaus Peter ^a,c   Casadome, Laura ^b   Menendez, Mireia ^b   Carpentier, Sabrina ^d   Barillot, Emmanuel ^d   Wagner, Mechthild ^e   Ansorge, Wilhelm ^e   Moeslein, Gabriela ^f   Fsihi, Hafida ^a   Bezrookove, Vladimir ^g   Reventos, Jaume ^h   Louvard, Daniel ^a   Capella, Gabriel ^b   Robine, Sylvie ^a  

^a INSTITUT CURIE   (France)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d INSTITUT CURIE   (France)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^f HEINRICH HEINE UNIVERSITY   (Germany)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTOME;

ADENOMATOUS POLYP; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BUB1B GENE; CHROMOSOMAL INSTABILITY; COLON POLYPOSIS; COLORECTAL CANCER; CONTROLLED STUDY; CYTOKINESIS; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE INACTIVATION; GENE MUTATION; HUMAN; HUMAN CELL; MAD2L1 GENE; MITOSIS; MOLECULAR GENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; UPREGULATION;

EID: 34250003718     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.03.027     Document Type: Article

References (31)

1. Rajagopalan H., Nowak M.A., Vogelstein B., and Lengauer C. The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer 3 (2003) 695-701
2. Lengauer C., Kinzler K.W., and Vogelstein B. Genetic instability in colorectal cancers. Nature 386 (1997) 623-627
3. Fodde R., Kuipers J., Rosenberg C., Smits R., Kielman M., Gaspar C., van Es J.H., Breukel C., Wiegant J., Giles R.H., and Clevers H. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat Cell Biol 3 (2001) 433-438
4. Kaplan K.B., Burds A.A., Swedlow J.R., Bekir S.S., Sorger P.K., and Nathke I.S. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol 3 (2001) 429-432
5. Gaspar C., and Fodde R. APC dosage effects in tumorigenesis and stem cell differentiation. Int J Dev Biol 48 (2004) 377-386
6. Green R.A., and Kaplan K.B. Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J Cell Biol 163 (2003) 949-961
7. Green R.A., Wollman R., and Kaplan K.B. APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. Mol Biol Cell 16 (2005) 4609-4622
8. Wang Z., Cummins J.M., Shen D., Cahill D.P., Jallepalli P.V., Wang T.L., Parsons D.W., Traverso G., Awad M., Silliman N., Ptak J., Szabo S., Willson J.K., Markowitz S.D., Goldberg M.L., Karess R., Kinzler K.W., Vogelstein B., Velculescu V.E., and Lengauer C. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res 64 (2004) 2998-3001
9. Fodde R., Edelmann W., Yang K., van Leeuwen C., Carlson C., Renault B., Breukel C., Alt E., Lipkin M., Khan P.M., et al. A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci U S A 91 (1994) 8969-8973
10. Janssen K.P., el-Marjou F., Pinto D., Sastre X., Rouillard D., Fouquet C., Soussi T., Louvard D., and Robine S. Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology 123 (2002) 492-504
11. Dudouet B., Robine S., Huet C., Sahuquillo-Merino C., Blair L., Coudrier E., and Louvard D. Changes in villin synthesis and subcellular distribution during intestinal differentiation of HT29-18 clones. J Cell Biol 105 (1987) 359-369
12. Waters J.C., Chen R.H., Murray A.W., and Salmon E.D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J Cell Biol 141 (1998) 1181-1191
13. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 98 (2001) 5116-5121
14. Huber W., and Gentleman R. Matchprobes: a bioconductor package for the sequence-matching of microarray probe elements. Bioinformatics 20 (2004) 1651-1652
15. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29 (2001) e45
16. Janssen K.P., Alberici P., Fsihi H., Gaspar C., Breukel C., Franken P., Rosty C., Abal M., El Marjou F., Smits R., Louvard D., Fodde R., and Robine S. APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression. Gastroenterology 131 (2006) 1096-1109
17. Ashburner M., Ball C.A., Blake J.A., Botstein D., Butler H., Cherry J.M., Davis A.P., Dolinski K., Dwight S.S., Eppig J.T., Harris M.A., Hill D.P., Issel-Tarver L., Kasarskis A., Lewis S., Matese J.C., Richardson J.E., Ringwald M., Rubin G.M., and Sherlock G. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25 (2000) 25-29
18. Beissbarth T., and Speed T.P. GOstat: find statistically overrepresented gene ontologies within a group of genes. Bioinformatics 20 (2004) 1464-1465
19. Taylor S.S., Hussein D., Wang Y., Elderkin S., and Morrow C.J. Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J Cell Sci 114 (2001) 4385-4395
20. Tighe A., Johnson V.L., and Taylor S.S. Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability. J Cell Sci 117 (2004) 6339-6353
21. Sotillo R., Hernando E., Diaz-Rodriguez E., Teruya-Feldstein J., Cordon-Cardo C., Lowe S.W., and Benezra R. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11 (2007) 9-23
22. Fodde R., Smits R., and Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 1 (2001) 55-67
23. Cardoso J., Molenaar L., de Menezes R.X., van Leerdam M., Rosenberg C., Moslein G., Sampson J., Morreau H., Boer J.M., and Fodde R. Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cancer Res 66 (2006) 2514-2519
24. Michel L.S., Liberal V., Chatterjee A., Kirchwegger R., Pasche B., Gerald W., Dobles M., Sorger P.K., Murty V.V., and Benezra R. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature 409 (2001) 355-359
25. Li G.Q., Li H., and Zhang H.F. Mad2 and p53 expression profiles in colorectal cancer and its clinical significance. World J Gastroenterol 9 (2003) 1972-1975
26. Hernando E., Nahle Z., Juan G., Diaz-Rodriguez E., Alaminos M., Hemann M., Michel L., Mittal V., Gerald W., Benezra R., Lowe S.W., and Cordon-Cardo C. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature 430 (2004) 797-802
27. Rimkus C., Friederichs J., Rosenberg R., Holzmann B., Siewert J.R., and Janssen K.P. Expression of the mitotic checkpoint gene MAD2L2 has prognostic significance in colon cancer. Int J Cancer 120 (2007) 207-211
28. Burds A.A., Lutum A.S., and Sorger P.K. Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc Natl Acad Sci U S A 102 (2005) 11296-11301
29. Rao C.V., Yang Y.M., Swamy M.V., Liu T., Fang Y., Mahmood R., Jhanwar-Uniyal M., and Dai W. Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc Natl Acad Sci U S A 102 (2005) 4365-4370
30. Sieber O.M., Heinimann K., Gorman P., Lamlum H., Crabtree M., Simpson C.A., Davies D., Neale K., Hodgson S.V., Roylance R.R., Phillips R.K., Bodmer W.F., and Tomlinson I.P. Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC. Proc Natl Acad Sci U S A 99 (2002) 16910-16915
31. Cahill D.P., Kinzler K.W., Vogelstein B., and Lengauer C. Genetic instability and darwinian selection in tumours. Trends Cell Biol 9 (1999) M57-M60