Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylon gastritis

Infection and Immunity

Volumn 75, Issue 6, 2007, Pages 2699-2707

  Lee, Chung Wei ^a   Rao, Varada P ^a   Rogers, Arlin B ^a   Ge, Zhongming ^a   Erdman, Susan E ^a   Whary, Mark T ^a   Fox, James G ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45RB ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; RAG2 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; GASTRITIS; GASTROENTERITIS; GENE EXPRESSION; HELICOBACTER PYLORI; IMMUNOREGULATION; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; STOMACH ANTRUM; WILD TYPE;

ANIMALS; DNA-BINDING PROTEINS; GASTRIC MUCOSA; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; INTERLEUKIN-10; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 34249895540     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01788-06     Document Type: Article

References (44)

1. Anderson, K. M., S. J. Czinn, R. W. Redline, and T. G. Blanchard. 2006. Induction of CTLA-4-mediated anergy contributes to persistent colonization in the murine model of gastric Helicobacter pylori infection. J. Immunol. 176:5306-5313.
2. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166:3008-3018.
3. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Potnie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995-1004.
4. + regulatory T cells: current controversies and future perspectives. Eur. J. Immunol. 36:2832-2836.
5. -/- mice. Am. J. Pathol. 152: 1377-1386.
6. Bodger, K., J. I. Wyatt, and R. V. Heatley. 1997. Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion. Gut 40:739-744.
7. + regulatory T cells by TGF-beta induction of transcription factor Foxp3. J. Exp. Med. 198:1875-1886.
8. hi T cells. J. Exp. Med. 190:1479-1492.
9. Dhar, D. K., T. C. Wang, R. Maruyama, J. Udagawa, H. Kubota, T. Fuji, M. Tachibana, T. Ono, H. Otani, and N. Nagasue. 2003. Expression of cytoplasmic TFF2 is a marker of tumor metastasis and negative prognostic factor in gastric cancer. Lab. Investig. 83:1343-1352.
10. Hi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Am. J. Pathol. 165:1257-1268.
11. Eaton, K. A., M. Mefford, and T. Thevenot. 2001. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J. Immunol. 166:7456-7461.
12. + regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. Am. J. Pathol. 162:691-702.
13. + regulatory lymphocytes require interleukin 10 to interrupt colon carcino-genesis in mice. Cancer Res. 63:6042-6050.
14. Fox, J. G., P. Beck, C. A. Dangler, M. T. Whary, T. C. Wang, H. N. Shi, and C. Nagler-Anderson. 2000. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy. Nat. Med. 6:536-542.
15. Fox, J. G., X. Li, R. J. Cahill, K. Andrutis, A. K. Rustgi, R. Odze, and T. C. Wang. 1996. Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology 110:155-166.
16. Fox, J. G., A. B. Rogers, M. Ihrig, N. S. Taylor, M. T. Whary, G. Dockray, A. Varro, and T. C. Wang. 2003. Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res. 63:942-950.
17. -/- C57BL/6 x Sv129 infected mice. Gastroenterology 130:A9.
18. Fox, J. G., and T. C. Wang. 2007. Inflammation, atrophy, and gastric cancer. J. Clin. Investig. 117:60-69.
19. Fox, J. G., T. C. Wang, A. B. Rogers, T. Poutahidis, Z. Ge, N. Taylor, C. A. Dangler, D. A. Israel, U. Krishna, K. Gaus, and R. M. Peek, Jr. 2003. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology 124:1879-1890.
20. Hansson, L. E., O. Nyren, A. W. Hsing, R. Bergstrom, S. Josefsson, W. H. Chow, J. F. Fraumeni, Jr., and H. O. Adami. 1996. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N. Engl. J. Med. 335:242-249.
21. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299:1057-1061.
22. Jiang, S., R. I. Lechler, X. S. He, and J. F. Huang. 2006. Regulatory T cells and transplantation tolerance. Hum. Immunol. 67:765-776.
23. Rang, W., S. Rathinavelu, L. C. Samuelson, and J. L. Merchant. 2005. Interferon gamma induction of gastric mucous neck cell hypertrophy. Lab. Investig. 85:702-715.
24. Karttunen, R. 1991. Blood lymphocyte proliferation, cytokine secretion and appearance of T cells with activation surface markers in cultures with Helicobacter pylori. Comparison of the responses of subjects with and without antibodies to H. pylori. Clin. Exp. Immunol. 83:396-400.
25. Kurt-Jones, E. A., L. Cao, F. Sandor, A. B. Rogers, M. T. Whary, P. R. Nambiar, A. Cerny, G. Bowen, J. Yan, S. Takaishi, A. L. Chi, G. Reed, J. Houghton, J. G. Fox, and T. C. Wang. 2007. Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect. Immun. 75:471-480.
26. Lee, A., J. G. Fox, G. Otto, and J. Murphy. 1990. A small animal model of human Helicobacter pylori active chronic gastritis. Gastroenterology 99:1315-1323.
27. Lee, A., J. O'Rourke, M. C. De Ungria, B. Robertson, G. Daskalopoulos, and M. F. Dixon. 1997. A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology 112:1386-1397.
28. Matsumoto, Y., T. G. Blanchard, M. L. Drakes, M. Basu, R. W. Redline, A. D. Levine, and S. J. Czinn. 2005. Eradication of Helicobacter pylori and resolution of gastritis in the gastric mucosa of IL-10-deficient mice. Helicobacter 10:407-415.
29. Mera, R., E. T. Fontham, L. E. Bravo, J. C. Bravo, M. B. Piazuelo, M. C. Camargo, and P. Correa. 2005. Long-term follow up of patients treated for Helicobacter pylori infection. Gut 54:1536-1540.
30. Mohammadi, M., S. Czinn, R. Redline, and J. Nedrud. 1996. Helicobacter-specific cell-mediated immune responses display a predominant Th1 pheno-type and promote a delayed-type hypersensitivity response in the stomachs of mice. J. Immunol. 156:4729-4738.
31. + T cells. J. Exp. Med. 178:237-244.
32. Pisani, P., D. M. Parkin, F. Bray, and J. Ferlay. 1999. Estimates of the worldwide mortality from 25 cancers in 1990. Int. J. Cancer 83:18-29.
33. + T cells induce or protect from chronic intestinal inflammation in C.B-17 SCID mice. Int. Immunol. 5:1461-1471.
34. + T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo. Gastroenterology 131:525-537.
35. + regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter pylori-infected mice. Clin. Exp. Immunol. 132:393-400.
36. Rogers, A. B., N. S. Taylor, M. T. Whary, E. D. Stefanich, T. C. Wang, and J. G. Fox. 2005. Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice. Cancer Res. 65:10709-10715.
37. Roth, K. A., S. B. Kapadia, S. M. Martin, and R. G. Lorenz. 1999. Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology. J. Immunol. 163:1490-1497.
38. Sakagami, T., M. Dixon, J. O'Rourke, R. Hewlett, F. Alderuccio, J. Velia, T. Shimoyama, and A. Lee. 1996. Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis. Gut 39:639-648.
39. Sarma-Rupavtarm, R. B., Z. Ge, D. B. Schauer, J. G. Fox, and M. F. Polz. 2004. Spatial distribution and stability of the eight microbial species of the altered Schaedler flora in the mouse gastrointestinal tract. Appl. Environ. Microbiol. 70:2791-2800.
40. Schmidt, P. H., J. R. Lee, V. Joshi, R. J. Playford, R. Poulsom, N. A. Wright, and J. R. Goldenring. 1999. Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab. Investig. 79:639-646.
41. + T cells. J. Autoimmun. 16:115-123.
42. -/- mice receiving adoptive transfer of T effector cells. Vet. Pathol. 42:707.
43. Wang, T. C., J. R. Goldenring, C. Dangler, S. Ito, A. Mueller, W. K. Jeon, T. J. Koh, and J. G. Fox. 1998. Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection. Gastroenterology 114:675-689.
44. Whary, M., B. Sheppard, J. Cline, S. Xu, and J. Fox. 2001. IL-10 deficiency reduces Helicobacter pylori gastric colonization in C57BL/6 mice. Gastroenterology 120:A99-A100.