Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-κB Activation and NF-κB-regulated gene products

Nutrition and Cancer

Volumn 57, Issue 1, 2007, Pages 78-87

  Sandur, Santosh K ^a   Kwang, Seok Ahn ^a   Ichikawa, Haruyo ^a   Sethi, Gautam ^a   Shishodia, Shishir ^a   Newman, Robert A ^b   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPHOR; CELL ADHESION MOLECULE; CIGARETTE SMOKE; CINEOLE; CURCUMIN; CYCLOOXYGENASE 2; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; ESTRAGOLE; EUGENOL; FLICE INHIBITORY PROTEIN; GELATINASE B; GENE PRODUCT; GINGEROL; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; PROTEIN BCL 2; PROTEIN BCL XL; ROSMARINIC ACID; SHOGAOL; SURVIVIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNCLASSIFIED DRUG; UNINDEXED DRUG; URSOLIC ACID; VASCULOTROPIN; ZYFLAMEND;

ANGIOGENESIS; ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BASIL; BERBERIS; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; COPTIS; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; GINGER; HERB; HU ZHANG; HUMAN; HUMAN CELL; METASTASIS; MOUSE; NONHUMAN; OREGANO; OSTEOCLAST; PROTEIN EXPRESSION; ROSEMARY; SCUTELLARIA BAICALENSIS; TEA;

EID: 34249891366     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580701268295     Document Type: Article

References (47)

1. Singh S and Aggarwal BB: Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J Biol Chem 270, 24995-25000, 1995.
2. Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, et al.: Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation. Mol Pharmacol 69, 195-206, 2006.
3. Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, et al.: Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. Oncogene 18, 6013-6020, 1999.
4. Paschka AG, Butler R, and Young CY: Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate. Cancer Lett 130, 1-7, 1998.
5. Kim DS, Kim HR, Woo ER, Hong ST, Chae HJ, et al.: Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase. Biochem Pharmacol 70, 1066-1078, 2005.
6. Huang SS and Zheng RL: Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett 239, 271-280, 2005.
7. Shishodia S, Majumdar S, Banerjee S, and Aggarwal BB: Ursolic acid inhibits nuclear tactor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2. matrix metalloproteinase 9, and cyclin D1. Cancer Res 63, 4375-4383, 2003.
8. Choi YH, Baek JH, Yoo MA, Chung HY, Kim ND, et al.: Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells. Int J Oncol 17, 565-571, 2000.
9. Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, et al.: [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 24, 2558-2567, 2005.
10. Atsumi T, Murakami Y, Shibuya K, Tonosaki K, and Fujisawa S: Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol. Anticancer Res 25, 4029-4036, 2005.
11. Tjendraputra E, Tran VH, Liu-Brennan D, Roufogalis BD, and Duke CC: Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorg Chem 29, 156-163, 2001.
12. Manna SK, Mukhopadhyay A, and Aggarwal BB: Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 164, 6509-6519, 2000.
13. Fukuda K, Hibiya Y, Mutoh M, Koshiji M, Akao S, et al.: Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 66, 227-233, 1999.
14. Kelm MA, Nair MG, Strasburg GM, and DeWitt DL: Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine 7, 7-13, 2000.
15. Bemis DL, Capodice JL, Anastasiadis AG, Katz AE, and Buttyan R: Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. Nutr Cancer 52, 202-212, 2005.
16. Aggarwal BB: Nuclear factor-kappaB: the enemy within. Cancer Cell 6, 203-208, 2004.
17. Anto RJ, Mukhopadhyay A, Shishodia S, Gairola CG, and Aggarwal BB: Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis 23, 1511-1518, 2002.
18. Bharti AC, Takada Y, Shishodia S, and Aggarwal BB: Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependem mechanism. J Biol Chem 279, 6065-6076, 2004.
19. Takada Y, Ichikawa H, Badmaev V, and Aggarwal BB: Acetyl-11-keto-beta- boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappaB and NF-kappaB-regulated gene expression. J Immunol 176, 3127-3140, 2006.
20. Chaturvedi MM, Mukhopadhyay A, and Aggarwal BB: Assay for redox-sensitive transcription factor. Methods Enzymol 319, 585-602, 2000.
21. Abu-Amer Y and Tondravi MM: NF-kappaB and bone: the breaking point. Nat Med 3, 1189-1190, 1997.
22. Liotta LA, Thorgeirsson UP, and Garbisa S: Role of collagenases in tumor cell invasion. Cancer Metastasis Rev 1, 277-288, 1982.
23. Van Antwerp DJ, Martin SJ, Kafri T, Green DR,and Verma IM: Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 274, 787-789, 1996.
24. Wang CY, Mayo MW, and Baldwin AS Jr: TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274, 784-787, 1996.
25. Yamamoto K, Arakawa T, Ueda N, and Yamamoto S: Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 270, 31315-31320, 1995.
26. Esteve PO, Chicoine E, Robledo O, Aoudjit F, Descoteaux A, et al.: Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B. J Biol Chem 277, 35150-35155, 2002.
27. van de Stolpe A, Caldenhoven E, Stade BG, Koenderman L, Raaijmakers JA, et al.: 12-O-Tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter. J Biol Chem 269, 6185-6192, 1994.
28. Zhu L, Fukuda S, Cordis G, Das DK, and Maulik N: Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett 508, 369-374, 2001.
29. Chu ZL, McKinsey TA, Liu L, Gentry JJ, Malim MH, et al.: Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis C-1AP2 is under NF-kappaB control. Proc Natl Acad Sci USA 94, 10057-10062, 1997.
30. You M, Ku PT, Hrdlickova R, and Bose HR Jr: ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein. Mol Cell Biol 17, 7328-7341, 1997.
31. Catz SD and Johnson JL: Transcriptional regulation of bcl-2 by nuclear factor kappa B and its significance in prostate cancer. Oncogene 20, 7342-7351, 2001.
32. Stehlik C, de Martin R, Kumabashiri I, Schmid JA, Binder BR, et al.: Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis. J Exp Med 188, 211-216, 1998.
33. Tamatani M, Che YH, Matsuzaki H, Ogawa S, Okado H, et al.: Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J Biol Chem 274, 8531-8538, 1999.
34. Schwenzer R, Siemienski K, Liptay S, Schubert G, Peters N, et al.: The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is up-regulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase. J Biol Chem 274, 19368-19374, 1999.
35. Kreuz S, Siegmund D, Scheurich P, and Wajant H: NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol Cell Biol 21, 3964-3973, 2001.
36. Shishodia S and Aggarwal BB: Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer. Cancer Treat Res 119, 139-173, 2004.
37. Takada Y, Singh S, and Aggarwal BB: Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem 279, 15096-15104, 2004.
38. Chainy GB, Manna SK, Chaturvedi MM, and Aggarwal BB: Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene 19, 2943-2950, 2000.
39. Yang F, Oz HS, Barve S, de Villiers WJ, McClain CJ, et al.: The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Mol Pharmacol 60, 528-533, 2001.
40. Hsiang CY, Wu SL, Cheng SE, and Ho TY: Acetaldehyde-induced interleukin-1beta and tumor necrosis factor-alpha production is inhibited by berberine through nuclear factor-kappaB signaling pathway in HepG2 cells. J Biomed Sci 12, 791-801, 2005.
41. Kang B Y, Chung SW, Kim SH, Cho D, and Kim TS: Involvement of nuclear factor-kappaB in the inhibition of interleukin-12 production from mouse macrophages by baicalein, a flavonoid in Scutellaria baicalensis. Planta Med 69, 687-691, 2003.
42. Nakamura N, Hayasaka S, Zhang XY, Nagaki Y, Matsumoto M, et al.: Effects of baicalin, baicalein, and wogonin on interleukin-6 and interleukin-8 expression, and nuclear factor-kappab binding activities induced by interleukin-1beta in human retinal pigment epithelial cell line. Exp Eye Res 77, 195-202, 2003.
43. Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71, 1397-1421, 2006.
44. Aggarwal BB, Shishodia S, Takada Y, Banerjee S, Newman RA, et al.: Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11, 7490-7498, 2005.
45. Bhurti AC, Takada Y, and Aggarwal BB: Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 172, 5940-5947, 2004.
46. Khafif A, Schantz SP, Chou TC, Edelstein D, and Sacks PG: Quantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells. Carcinogenesis 19, 419-424, 1998.
47. Balasubramanian S and Eckert RL: Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. J Biol Chem 279, 24007-24014, 2004.