메뉴 건너뛰기




Volumn 14, Issue 12, 2007, Pages 950-959

Sensitive and precise regulation of haemoglobin after gene transfer of erythropoietin to muscle tissue using electroporation

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DOXYCYCLINE; DRINKING WATER; ERYTHROPOIETIN; GREEN FLUORESCENT PROTEIN; HEMOGLOBIN; LUCIFERASE;

EID: 34249863632     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302951     Document Type: Article
Times cited : (58)

References (50)
  • 1
    • 0037383050 scopus 로고    scopus 로고
    • Electroporation: Theory and methods, perspectives for drug delivery, gene therapy and research
    • Gehl J. Electroporation: Theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol Scand 2003; 177: 437-447.
    • (2003) Acta Physiol Scand , vol.177 , pp. 437-447
    • Gehl, J.1
  • 2
    • 0034194049 scopus 로고    scopus 로고
    • Importance of association between permeabilisation and electrophoretic forces for intramuscular DNA electrotransfer
    • Bureau MF, Gehl J, Deleuze V, Mir LM, Scherman D. Importance of association between permeabilisation and electrophoretic forces for intramuscular DNA electrotransfer. Biochim Biophys Acta 2000; 1474: 353-359.
    • (2000) Biochim Biophys Acta , vol.1474 , pp. 353-359
    • Bureau, M.F.1    Gehl, J.2    Deleuze, V.3    Mir, L.M.4    Scherman, D.5
  • 3
    • 0036166304 scopus 로고    scopus 로고
    • Mechanisms of in vivo DNA electrotransfer: Respective contributions of cell electropermeabilisation and DNA electrophoresis
    • Satkauskas S, Bureau MF, Puc M, Mahfoudi A, Scherman D, Miklavcic D et al. Mechanisms of in vivo DNA electrotransfer: Respective contributions of cell electropermeabilisation and DNA electrophoresis. Mol Ther 2002; 5: 133-140.
    • (2002) Mol Ther , vol.5 , pp. 133-140
    • Satkauskas, S.1    Bureau, M.F.2    Puc, M.3    Mahfoudi, A.4    Scherman, D.5    Miklavcic, D.6
  • 4
    • 26644463007 scopus 로고    scopus 로고
    • Electrophoretic component of electric pulses determines the efficacy of in vivo DNA electrotransfer
    • Satkauskas S, Andre F, Bureau M, Scherman D, Miklavcic D, Mir LM. Electrophoretic component of electric pulses determines the efficacy of in vivo DNA electrotransfer. Hum Gene Ther 2005; 16: 1194-1201.
    • (2005) Hum Gene Ther , vol.16 , pp. 1194-1201
    • Satkauskas, S.1    Andre, F.2    Bureau, M.3    Scherman, D.4    Miklavcic, D.5    Mir, L.M.6
  • 5
    • 33751035728 scopus 로고    scopus 로고
    • Electrochemotherapy - an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study
    • Marty M, Sersa G, Garbay JR, Gehl J, Collins CG, Snoj M et al. Electrochemotherapy - an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. Eur J Cancer Suppl 2006; 4: 3-13.
    • (2006) Eur J Cancer Suppl , vol.4 , pp. 3-13
    • Marty, M.1    Sersa, G.2    Garbay, J.R.3    Gehl, J.4    Collins, C.G.5    Snoj, M.6
  • 6
    • 33750526248 scopus 로고    scopus 로고
    • Palliation of haemorrhaging and ulcerated cutaneous tumours using electrochemotherapy
    • Gehl J, Geertsen PF. Palliation of haemorrhaging and ulcerated cutaneous tumours using electrochemotherapy. Eur J Cancer Suppl 2006; 4 35-37.
    • (2006) Eur J Cancer Suppl , vol.4 , pp. 35-37
    • Gehl, J.1    Geertsen, P.F.2
  • 7
    • 33750500516 scopus 로고    scopus 로고
    • Bases and rationale of the electrochemotherapy
    • Mir LM. Bases and rationale of the electrochemotherapy. Eur J Cancer Suppl 2006; 4: 38-44.
    • (2006) Eur J Cancer Suppl , vol.4 , pp. 38-44
    • Mir, L.M.1
  • 8
    • 33750626735 scopus 로고    scopus 로고
    • In vivo electroporation for gene therapy
    • Heller LC, Heller R. In vivo electroporation for gene therapy. Hum Gene Ther 2006; 17: 890-897.
    • (2006) Hum Gene Ther , vol.17 , pp. 890-897
    • Heller, L.C.1    Heller, R.2
  • 9
    • 0037267444 scopus 로고    scopus 로고
    • Non-viral gene delivery in skeletal muscle: A protein factory
    • Lu QL, Bou-Gharios G, Partridge TA. Non-viral gene delivery in skeletal muscle: A protein factory. Gene Therapy 2003; 10: 131-142.
    • (2003) Gene Therapy , vol.10 , pp. 131-142
    • Lu, Q.L.1    Bou-Gharios, G.2    Partridge, T.A.3
  • 10
    • 0033154484 scopus 로고    scopus 로고
    • Erythropoietin secretion and physiological effect in mouse after intramuscular plasmid DNA electrotransfer
    • Kreiss P, Bettan M, Crouzet J, Scherman D. Erythropoietin secretion and physiological effect in mouse after intramuscular plasmid DNA electrotransfer. J Gene Med 1999; 1: 245-250.
    • (1999) J Gene Med , vol.1 , pp. 245-250
    • Kreiss, P.1    Bettan, M.2    Crouzet, J.3    Scherman, D.4
  • 11
    • 13044286785 scopus 로고    scopus 로고
    • Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation
    • Rizzuto G, Cappelletti M, Maione D, Savino R, Lazzaro D, Costa P et al. Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation. Proc Natl Acad Sci USA 1999; 96: 6417-6422.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6417-6422
    • Rizzuto, G.1    Cappelletti, M.2    Maione, D.3    Savino, R.4    Lazzaro, D.5    Costa, P.6
  • 12
    • 0035108551 scopus 로고    scopus 로고
    • Improvement of mouse [beta]-thalassemia by electrotransfer of erythropoietin cDNA
    • Payen E, Bettan M, Rouyer-Fessard P, Beuzard Y, Scherman D. Improvement of mouse [beta]-thalassemia by electrotransfer of erythropoietin cDNA. Exp Hematol 2001; 29: 295-300.
    • (2001) Exp Hematol , vol.29 , pp. 295-300
    • Payen, E.1    Bettan, M.2    Rouyer-Fessard, P.3    Beuzard, Y.4    Scherman, D.5
  • 13
    • 0034628485 scopus 로고    scopus 로고
    • Continuous erythropoietin delivery by muscletargeted gene transfer using in vivo electroporation
    • Maruyama H, Sugawa M, Moriguchi Y, Imazeki I, Ishikawa Y, Ataka K et al. Continuous erythropoietin delivery by muscletargeted gene transfer using in vivo electroporation. Hum Gene Ther 2000; 11: 429-437.
    • (2000) Hum Gene Ther , vol.11 , pp. 429-437
    • Maruyama, H.1    Sugawa, M.2    Moriguchi, Y.3    Imazeki, I.4    Ishikawa, Y.5    Ataka, K.6
  • 14
    • 0034804570 scopus 로고    scopus 로고
    • Efficient and ligand-dependent regulated erythropoietin production by naked dna injection and in vivo electroporation
    • Terada Y, Tanaka H, Okado T, Inoshita S, Kuwahara M, Akiba T et al. Efficient and ligand-dependent regulated erythropoietin production by naked dna injection and in vivo electroporation. Am J Kidney Dis 2001; 38: S50-S53.
    • (2001) Am J Kidney Dis , vol.38
    • Terada, Y.1    Tanaka, H.2    Okado, T.3    Inoshita, S.4    Kuwahara, M.5    Akiba, T.6
  • 15
    • 0035202033 scopus 로고    scopus 로고
    • In vivo gene electroporation in skeletal muscle with special reference to the duration of gene expression
    • Muramatsu T, Arakawa S, Fukazawa K, Fujiwara Y, Yishida T, Sasaki R et al. In vivo gene electroporation in skeletal muscle with special reference to the duration of gene expression. Int J Mol Med 2001; 7: 37-42.
    • (2001) Int J Mol Med , vol.7 , pp. 37-42
    • Muramatsu, T.1    Arakawa, S.2    Fukazawa, K.3    Fujiwara, Y.4    Yishida, T.5    Sasaki, R.6
  • 16
    • 17744391278 scopus 로고    scopus 로고
    • Long-term production of erythropoietin after electroporation-mediated transfer of plasmid DNA into the muscles of normal and uremic rats
    • Maruyama H, Ataka K, Gejyo F, Higuchi N, Ito Y, Hirahara H et al. Long-term production of erythropoietin after electroporation-mediated transfer of plasmid DNA into the muscles of normal and uremic rats. Gene Therapy 2001; 8: 461-468.
    • (2001) Gene Therapy , vol.8 , pp. 461-468
    • Maruyama, H.1    Ataka, K.2    Gejyo, F.3    Higuchi, N.4    Ito, Y.5    Hirahara, H.6
  • 17
    • 0141681012 scopus 로고    scopus 로고
    • Effects of erythropoietin-gene electrotransfer in rats with adenine-induced renal failure
    • Ataka K, Maruyama H, Neichi T, Miyazaki J, Gejko F. Effects of erythropoietin-gene electrotransfer in rats with adenine-induced renal failure. Am J Nephrol 2003; 23: 315-323.
    • (2003) Am J Nephrol , vol.23 , pp. 315-323
    • Ataka, K.1    Maruyama, H.2    Neichi, T.3    Miyazaki, J.4    Gejko, F.5
  • 18
    • 0034283880 scopus 로고    scopus 로고
    • Gene electrotransfer results in a high-level transduction of rat skeletal muscle and corrects anemia of renal failure
    • Rizzuto G, CappellettiM, Mennuni C,Wiznerowicz M, DeMartis A, Maione D et al. Gene electrotransfer results in a high-level transduction of rat skeletal muscle and corrects anemia of renal failure. Hum Gene Ther 2000; 11: 1891-1900.
    • (2000) Hum Gene Ther , vol.11 , pp. 1891-1900
    • Rizzuto, G.1    Cappelletti, M.2    Mennuni, C.3    Wiznerowicz, M.4    DeMartis, A.5    Maione, D.6
  • 19
  • 21
    • 1942537842 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Transcription regulatory systems
    • Toniatti C, Bujard H, Cortese R, Ciliberto G. Gene therapy progress and prospects: Transcription regulatory systems. Gene Therapy 2004; 11: 649-657.
    • (2004) Gene Therapy , vol.11 , pp. 649-657
    • Toniatti, C.1    Bujard, H.2    Cortese, R.3    Ciliberto, G.4
  • 23
    • 0347264779 scopus 로고    scopus 로고
    • Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: Application to interleukin 10 therapy in experimental arthritis
    • Perez N, Plence P, Millet V, Greuet D, Minot C, Noel D et al. Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: application to interleukin 10 therapy in experimental arthritis. Hum Gene Ther 2002; 13: 2161-2172.
    • (2002) Hum Gene Ther , vol.13 , pp. 2161-2172
    • Perez, N.1    Plence, P.2    Millet, V.3    Greuet, D.4    Minot, C.5    Noel, D.6
  • 24
    • 18244382853 scopus 로고    scopus 로고
    • Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators
    • Lamartina S, Roscilli G, Rinaudo CD, Sporeno E, Silvi L, Hillen W et al. Stringent control of gene expression in vivo by using novel doxycycline-dependent trans-activators. Hum Gene Ther 2002; 13 199-210.
    • (2002) Hum Gene Ther , vol.13 , pp. 199-210
    • Lamartina, S.1    Roscilli, G.2    Rinaudo, C.D.3    Sporeno, E.4    Silvi, L.5    Hillen, W.6
  • 25
    • 1642525149 scopus 로고    scopus 로고
    • Optimal design of a single recombinant adenoassociated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle
    • Chenuaud P, Larcher T, Rabinowitz JE, Provost N, Joussemet B, Bujard H et al. Optimal design of a single recombinant adenoassociated virus derived from serotypes 1 and 2 to achieve more tightly regulated transgene expression from nonhuman primate muscle. Mol Ther 2004; 9: 410-418.
    • (2004) Mol Ther , vol.9 , pp. 410-418
    • Chenuaud, P.1    Larcher, T.2    Rabinowitz, J.E.3    Provost, N.4    Joussemet, B.5    Bujard, H.6
  • 26
    • 0342844383 scopus 로고    scopus 로고
    • Avalidated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy
    • Miklavcic D, Semrov D, Mekid H, Mir LM. Avalidated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim Biophys Acta 2000; 1523: 73-83.
    • (2000) Biochim Biophys Acta , vol.1523 , pp. 73-83
    • Miklavcic, D.1    Semrov, D.2    Mekid, H.3    Mir, L.M.4
  • 28
    • 0031040987 scopus 로고    scopus 로고
    • Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts
    • Bohl D, Naffakh N, Heard JM. Long-term control of erythropoietin secretion by doxycycline in mice transplanted with engineered primary myoblasts. Nat Med 1997; 3: 299-305.
    • (1997) Nat Med , vol.3 , pp. 299-305
    • Bohl, D.1    Naffakh, N.2    Heard, J.M.3
  • 29
    • 34249897864 scopus 로고    scopus 로고
    • Tet-On induction with doxycycline after gene transfer in mice: Sweetening of drinking water is not a good idea
    • In press
    • Moller PH, Eriksen J, Gehl J. Tet-On induction with doxycycline after gene transfer in mice: Sweetening of drinking water is not a good idea. Anim Biotechnol. In press.
    • Anim Biotechnol
    • Moller, P.H.1    Eriksen, J.2    Gehl, J.3
  • 30
    • 0141502361 scopus 로고    scopus 로고
    • Electrochemotherapy: Results of cancer treatment using enhanced delivery of bleomycin by electroporation
    • Gothelf A, Mir LM, Gehl J. Electrochemotherapy: Results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treat Rev 2003; 29: 371-387.
    • (2003) Cancer Treat Rev , vol.29 , pp. 371-387
    • Gothelf, A.1    Mir, L.M.2    Gehl, J.3
  • 31
    • 33751051150 scopus 로고    scopus 로고
    • Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes
    • Mir LM, Gehl J, Sersa G, Collins CG, Garbay J, Billard V et al. Standard operating procedures of the electrochemotherapy: Instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. Eur J Cancer Suppl 2006; 4: 14-25.
    • (2006) Eur J Cancer Suppl , vol.4 , pp. 14-25
    • Mir, L.M.1    Gehl, J.2    Sersa, G.3    Collins, C.G.4    Garbay, J.5    Billard, V.6
  • 32
    • 0031753867 scopus 로고    scopus 로고
    • Gene transfer into muscle by electroporation in vivo
    • Aihara H, Miyazaki J. Gene transfer into muscle by electroporation in vivo. Nat Biotechnol 1998; 16: 867-870.
    • (1998) Nat Biotechnol , vol.16 , pp. 867-870
    • Aihara, H.1    Miyazaki, J.2
  • 33
    • 0032791198 scopus 로고    scopus 로고
    • In vivo electroporation of skeletal muscle: Threshold, efficacy and relation to electric field distribution
    • Gehl J, Sorensen TH, Nielsen K, Raskmark P, Nielsen SL, Skovsgaard T et al. In vivo electroporation of skeletal muscle: Threshold, efficacy and relation to electric field distribution. Biochim Biophys Acta 1999; 1428: 233-240.
    • (1999) Biochim Biophys Acta , vol.1428 , pp. 233-240
    • Gehl, J.1    Sorensen, T.H.2    Nielsen, K.3    Raskmark, P.4    Nielsen, S.L.5    Skovsgaard, T.6
  • 34
    • 0035870104 scopus 로고    scopus 로고
    • betaMinor-globin messenger RNA accumulation in reticulocytes governs improved erythropoiesis in beta thalassemic mice after erythropoietin complementary DNA electrotransfer in muscles
    • Samakoglu S, Fattori E, Lamartina S, Toniatti C, Stockholm D, Heard JM et al. betaMinor-globin messenger RNA accumulation in reticulocytes governs improved erythropoiesis in beta thalassemic mice after erythropoietin complementary DNA electrotransfer in muscles. Blood 2001; 97: 2213-2220.
    • (2001) Blood , vol.97 , pp. 2213-2220
    • Samakoglu, S.1    Fattori, E.2    Lamartina, S.3    Toniatti, C.4    Stockholm, D.5    Heard, J.M.6
  • 35
    • 25844488169 scopus 로고    scopus 로고
    • Kinetic of transgene expression after electrotransfer into skeletal muscle: Importance of promoter origin/strength
    • Durieux AC, Bonnefoy R, Freyssenet D. Kinetic of transgene expression after electrotransfer into skeletal muscle: Importance of promoter origin/strength. Biochim Biophys Acta 2005; 1725: 403-409.
    • (2005) Biochim Biophys Acta , vol.1725 , pp. 403-409
    • Durieux, A.C.1    Bonnefoy, R.2    Freyssenet, D.3
  • 36
    • 33744785076 scopus 로고    scopus 로고
    • Comparison of promoter region constructs for in vivo intramuscular expression
    • Fabre E, Bigey P, Orsini C, Scherman D. Comparison of promoter region constructs for in vivo intramuscular expression. J Gene Med 2006; 8: 636-645.
    • (2006) J Gene Med , vol.8 , pp. 636-645
    • Fabre, E.1    Bigey, P.2    Orsini, C.3    Scherman, D.4
  • 37
    • 0037227316 scopus 로고    scopus 로고
    • Erythropoietin: Physiology and pharmacology update
    • Fisher JW. Erythropoietin: Physiology and pharmacology update. Exp Biol Med 2003; 228: 1-14.
    • (2003) Exp Biol Med , vol.228 , pp. 1-14
    • Fisher, J.W.1
  • 38
    • 5444236205 scopus 로고    scopus 로고
    • Challenges and strategies: The immune responses in gene therapy
    • Zhou HS, Liu DP, Liang CC. Challenges and strategies: The immune responses in gene therapy. Med Res Rev 2004; 24: 748-761.
    • (2004) Med Res Rev , vol.24 , pp. 748-761
    • Zhou, H.S.1    Liu, D.P.2    Liang, C.C.3
  • 39
    • 0032926935 scopus 로고    scopus 로고
    • Electropermeabilisation of skeletal muscle enhances gene transfer in vivo
    • Mathiesen I. Electropermeabilisation of skeletal muscle enhances gene transfer in vivo. Gene Therapy 1999; 6: 508-514.
    • (1999) Gene Therapy , vol.6 , pp. 508-514
    • Mathiesen, I.1
  • 41
    • 25144473571 scopus 로고    scopus 로고
    • A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation
    • Wang XD, Tang JG, Xie XL, Yang JC, Li S, Ji JG et al. A comprehensive study of optimal conditions for naked plasmid DNA transfer into skeletal muscle by electroporation. J Gene Med 2005; 7: 1235-1245.
    • (2005) J Gene Med , vol.7 , pp. 1235-1245
    • Wang, X.D.1    Tang, J.G.2    Xie, X.L.3    Yang, J.C.4    Li, S.5    Ji, J.G.6
  • 42
    • 4444279151 scopus 로고    scopus 로고
    • Factors influencing the efficacy, longevity, and safety of electroporation-assisted plasmid-based gene transfer into mouse muscles
    • Molnar MJ, Gilbert R, Lu Y, Liu AB, Guo A, Larochelle N et al. Factors influencing the efficacy, longevity, and safety of electroporation-assisted plasmid-based gene transfer into mouse muscles. Mol Ther 2004; 10: 447-455.
    • (2004) Mol Ther , vol.10 , pp. 447-455
    • Molnar, M.J.1    Gilbert, R.2    Lu, Y.3    Liu, A.B.4    Guo, A.5    Larochelle, N.6
  • 43
    • 0035184531 scopus 로고    scopus 로고
    • Electroporation-facilitated delivery of plasmid DNA in skeletal muscle: Plasmid dependence of muscle damage and effect of poloxamer 188
    • Hartikka J, Sukhu L, Buchner C, Hazard D, Bozoukova V, Margalith M et al. Electroporation-facilitated delivery of plasmid DNA in skeletal muscle: Plasmid dependence of muscle damage and effect of poloxamer 188. Mol Ther 2001; 4: 407-415.
    • (2001) Mol Ther , vol.4 , pp. 407-415
    • Hartikka, J.1    Sukhu, L.2    Buchner, C.3    Hazard, D.4    Bozoukova, V.5    Margalith, M.6
  • 44
    • 4644275773 scopus 로고    scopus 로고
    • In vivo gene electrotransfer into skeletal muscle: Effects of plasmid DNA on the occurrence and extent of muscle damage
    • Durieux A, Bonnefoy R, Busso T, Freyssenet D. In vivo gene electrotransfer into skeletal muscle: Effects of plasmid DNA on the occurrence and extent of muscle damage. J Gene Med 2004; 6: 809-816.
    • (2004) J Gene Med , vol.6 , pp. 809-816
    • Durieux, A.1    Bonnefoy, R.2    Busso, T.3    Freyssenet, D.4
  • 45
    • 0035861219 scopus 로고    scopus 로고
    • Wang M, Orsini C, Casanova D, Millan JL, Mahfoudi A, Thuillier V. MUSEAP, a novel reporter gene for the study of long-term gene expression in immunocompetent mice. Gene 2001; 279: 99-108.
    • Wang M, Orsini C, Casanova D, Millan JL, Mahfoudi A, Thuillier V. MUSEAP, a novel reporter gene for the study of long-term gene expression in immunocompetent mice. Gene 2001; 279: 99-108.
  • 46
    • 12144285637 scopus 로고    scopus 로고
    • Evidence of antiangiogeni and antimetastatic activities of the recombinant disintegrin domain of metargidin
    • Trochon-Joseph V, Martel-Renoir D, Mir LM, Thomaidis A, Opolon P, Connault E et al. Evidence of antiangiogeni and antimetastatic activities of the recombinant disintegrin domain of metargidin. Cancer Res 2004; 64: 2062-2069.
    • (2004) Cancer Res , vol.64 , pp. 2062-2069
    • Trochon-Joseph, V.1    Martel-Renoir, D.2    Mir, L.M.3    Thomaidis, A.4    Opolon, P.5    Connault, E.6
  • 48
    • 0034269179 scopus 로고    scopus 로고
    • High-level protein secretion into blood circulation after electric pulse-mediated gene transfer into skeletal muscle
    • Bettan M, Emmanuel F, Darteil R, Caillaud JM, Soubrier F, Delaère P et al. High-level protein secretion into blood circulation after electric pulse-mediated gene transfer into skeletal muscle. Mol Ther 2000; 2: 204-210.
    • (2000) Mol Ther , vol.2 , pp. 204-210
    • Bettan, M.1    Emmanuel, F.2    Darteil, R.3    Caillaud, J.M.4    Soubrier, F.5    Delaère, P.6
  • 49
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992; 89: 5547-5551.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 50
    • 0029763587 scopus 로고    scopus 로고
    • Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
    • Kistner A, Gossen M, Zimmermann F, Jerecic J, Ullmer C, Lübbert H et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci USA 1996; 93: 10933-10938.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10933-10938
    • Kistner, A.1    Gossen, M.2    Zimmermann, F.3    Jerecic, J.4    Ullmer, C.5    Lübbert, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.