Tetracycline transcriptional silencer tightly controls transgene expression after in vivo intramuscular electrotransfer: Application to interleukin 10 therapy in experimental arthritis

Human Gene Therapy

Volumn 13, Issue 18, 2002, Pages 2161-2172

  Perez, Norma ^a   Plence, Pascale ^b   Millet, Virginie ^b   Greuet, Denis ^b   Minot, Caroline ^a   Noel, Daniele ^b   Danos, Olivier ^a   Jorgensen, Christian ^b,c   Apparailly, Florence ^b  

^a GÉNÉTHON   (France)

^b INSERM   (France)

^c LAPEYRONIE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE INDUCIBLE REVERSE TETRACYCLINE TRANSACTIVATOR; HYBRID PROTEIN; INTERLEUKIN 10; LUCIFERASE; TETRACYCLINE TRANSCRIPTIONAL SILENCER; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; ELECTROTRANSFER; FEMALE; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE SILENCING; GENE TRANSFER; GENETIC TRANSCRIPTION; MALE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN BINDING; REPORTER GENE; TRANSGENE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPORATION; FEMALE; GENE EXPRESSION REGULATION, VIRAL; GENE THERAPY; GENETIC VECTORS; INJECTIONS, INTRAMUSCULAR; INTERLEUKIN-10; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PLASMIDS; TETRACYCLINE; TRANSFECTION;

ANIMALIA;

EID: 0347264779     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303402320987851     Document Type: Article

References (41)

1. AIHARA, H., and MIYAZAKI, J. (1998). Gene transfer into muscle by electroporation in vivo. Nat. Biotechnol. 16, 867-870.
2. APPARAILLY. F., VERWAERDE, C., JACQUET, C., AURIAULT, C., SANY J., and JORGENSEN, C. (1998). Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. J. Immunol. 160, 5213-5220.
3. APPARAILLY, F., MILLET, V., NOEL, D., JACQUET, C., SANY, J., and JORGENSEN, C. (2002). Tetracycline-inducible IL-10 gene transfer mediated by an adeno-associated virus: Application to experimental arthritis. Hum. Gene Ther. 13, 1179-1188.
4. BARON, U., and BUJARD, H. (2000). Tet repressor-based system for regulated gene expression in eukaryotic cells: Principles and advances. Methods Enzymol. 327, 401-421.
5. BOHL, D., SALVETTI, A., MOULLIER, P., and HEARD, J.M. (1998). Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector. Blood 92, 1512-1517.
6. FREUNDLIEB, S., SCHIRRA-MULLER, C., and BUJARD, H. (1999). A tetracycline controlled activation/repression system with increased potential for gene transfer into mammalian cells. J. Gene Med. 1, 4-12.
7. FISHMAN, G.I., KAPLAN, M.L., and BUTTRICK, P.M. (1994). Tetracycline-regulated cardiac gene expression in vivo. J. Clin. Invest. 93, 1864-1868.
8. FURTH, P.A., ST ONGE, L., BOGER, H., GRUSS. P., GOSSEN, M., KISTNER, A., BUJARD, H., and HENNIGHAUSEN, L. (1994). Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc. Natl. Acad. Sci. U.S.A. 91, 9302-9306.
9. GARI, E., PIEDRAFITA, L., ALDEA, M., and HERRERO, E. (1997). A set of vectors with a tetracycline-regulatable promoter system for modulated gene expression in Saccharomyces cerevisiae. Yeast 13, 837-848.
10. GHIVIZZANI, S.C., LECHMAN, E.R., KANG, R., TIO, C., KOLLS, J., EVANS, C.H., and ROBBINS, P.D. (1998). Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc. Natl. Acad. Sci. U.S.A. 95, 4613-4618.
11. GIRARD, F., BELLO, B., LAEMMLI, U.K., and GEHRING, W.J. (1998). In vivo analysis of scaffold-associated regions in Drosophila: A synthetic high-affinity SAR binding protein suppresses position effect variegation. EMBO J. 17, 2079-2085.
12. GOSSEN, M., and BUJARD, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 89, 5547-5551.
13. GOSSEN, M., FREUNDLIEB, S., BENDER, G., MULLER, G., HILLEN, W., and BUJARD, H. (1995). Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-1769.
14. HARDING, T.C., GEDDES, B.J., MURPHY, D., KNIGHT, D., and UNEY, J.B. (1998). Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system, Nat. Biotechnol. 16, 553-555.
15. JOOSTEN, L.A., LUBBERTS, E., DUREZ, P., HELSEN, M.M., JACOBS, M.J., GOLDMAN, M., and VAN DEN BERG, W.B. (1997). Role of interleukin-4 and interieukin-10 in murine collagen-induced arthritis: Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction. Arthritis Rheum. 40, 249-260.
16. KISTNER, A., GOSSEN, M., ZIMMERMANN, F., JERECIC, J., ULLMER, C., LUBBERT, H., and BUJARD, H. (1996). Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 93, 10933-10938.
17. LECHMAN, E.R., JAFFURS, D., GHIVIZZANI, S.C., GAMBOTTO, A., KOVESDI, I., MI, Z., EVANS, C.H., and ROBBINS, P.D. (1999). Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J. Immunol. 163, 2202-2208.
18. MA, Y., THORNTON, S., DUWEL, L.E., BOIVIN, G.P., GIANNINI, E.H., LEIDEN, J., BLUESTONE, J.A., and HIRSCH, R. (1998). Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J. Immunol. 161, I516-1524.
19. MATHIESEN, I. (1999). Electropermeabilization of skeletal muscle enhances gene transfer in vivo. Gene Ther. 6, 508-514.
20. MCGEE SANFTNER. L.H., RENDAHL, K.G., QUIROZ, D., COYNE, M., LADNER, M., MANNING, W.C., and FLANNERY, J.G. (2001). Recombinant AAV-mediated delivery of a tet-inducible reporter gene to the rat retina. Mol. Ther. 3, 688-696.
21. MIR, L.M., BUREAU, M.F., RANGARA, R., SCHWARTZ, B., and SCHERMAN, D. (1998). Long-term, high level in vivo gene expression after electric pulse-mediated gene transfer into skeletal muscle. C. R. Acad. Sci. III 321, 893-899.
22. MIR, L.M., BUREAU, M.F., GEHL, J., RANGARA, R., ROUY, D., CAILLAUD, J.M., DELAERE, P., BRANELLEC, D., SCHWARTZ, B., and SCHERMAN, D. (1999). High-efficiency gene transfer into skeletal muscle mediated by electric pulses. Proc. Natl. Acad. Sci. U.S.A. 96, 4262-4267.
23. PEREZ, N., POUPIOT, J., GINOUHX, F., TURBANT, S., GICQUEL, E., BAUDRY, L., BOUSSAT, S., BARDE, I., THUILLER, V., and DANOS, O. Immune response against rtTA eliminates doxycycline-dependent transgene expression in mouse skeletal muscle when using nonviral gene transfer. In preparation.
24. PRUD'HOMME, G.J. (2000). Gene therapy of autoimmune diseases with vectors encoding regulatory cytokines or inflammatory cytokine inhibitors. J. Gene Med. 2, 222-232.
25. QIN, L., CHAVIN, K.D., DING, Y., TAHARA, H., FAVARO, J.P., WOODWARD, J.E., SUZUKI, T., ROBBINS, P.D., LOTZE, M.T., and BROMBERG, J.S. (1996). Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival. J. Immunol. 156, 2316-2323.
26. RENDAHL, K.G., QUIROZ, D., LADNER, M., COYNE, M., SELTZER, J., MANNING, W.C., and ESCOBEDO, J.A. (2002). Tightly regulated long-term erythropoietin expression in vivo using tet-inducible recombinant adeno-associated viral vectors. Hum. Gene Ther. 13, 335-342.
27. RYAN, M.E., GREENWALD, R.A., and GOLUB, L.M. (1996). Potential of tetracyclines to modify cartilage breakdown in osteoarthritis. Curr. Opin. Rheumatol. 8, 238-247.
28. SANDER, A., GUTH, A., BRENNER, H.R., and WITZEMANN, V. (2000). Gene transfer into individual muscle fibers and conditional gene expression in living animals. Cell Tissue Res. 301, 397-403.
29. SNYDER, R.O., SPRATT, S.K., LAGARDE, C., BOHL, D., KASPAR, B., SLOAN, B., COHEN, L.K., and DANOS, O. (1997). Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice. Hum. Gene Ther. 8, 1891-1900.
30. ST CLAIR, E.W., WILKINSON, W.E., PISETSKY, D.S., SEXTON, D.J., DREW, R., KRAUS, V.B., and GREENWALD, R.A. (2001). The effects of intravenous doxycycline therapy for rheumatoid arthritis: A randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 44, 1043-1047.
31. SUZUKI, T., TAHARA, H., NARULA, S., MOORE, K.W., ROBBINS, P.D., and LOTZE, M.T. (1995). Viral interleukin 10 (IL-10), the human herpes virus 4 cellular IL-10 homologue, induces local anergy to allogeneic and syngeneic tumors. J. Exp. Med. 182, 477-486.
32. TICHELAAR, J.W., LU, W., and WHITSETT, J.A. (2000). Conditional expression of fibroblast growth factor-7 in the developing and mature lung. J. Biol. Chem. 275, 11858-11864.
33. URLINGER, S., BARON, U., THELLMANN, M., HASAN, M.T., BUJARD, H., and HILLEN, W. (2000). Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity. Proc. Natl. Acad. Sci. U.S.A. 97, 7963-7968.
34. VAN DER LAAN, W., MOLENAAR, E., RONDAY, K., VERHEIJEN, J., BREEDVELD, F., GREENWALD, R., DIJKMANS, B., and TEKOPPELE, J. (2001). Lack of effect of doxycycline on disease activity and joint damage in patients with rheumatoid arthritis: A double blind, placebo controlled trial. J. Rheumatol. 28, 1967-1974.
35. VERWAERDE, C., THIAM, K., DELANOYE, A., FERNANDEZ-GOMEZ, R., D'HALLUIN, J., and AURIAULT, C. (1999). Systemic delivery of an adenovirus expressing EBV-derived vIL-10 in mice infected with Schistosoma mansoni or Leishmania amazonensis: Controversial effects on the development of pathological parameters. Eur. Cytokine Netw. 10, 161-170.
36. WATANABE, S., KIM, K.N., IMAGAWA, T., THORNTON, S., GROM, A., and HIRSCH, R. (2000). On the mechanism of protection of distal joints after local gene transfer in collagen-induced arthritis. Hum. Gene Ther. 11, 751-758.
37. WEINMANN, P., GOSSEN, M., HILLEN, W., BUJARD, H., and GATZ, C. (1994). A chimeric transactivator allows tetracycline-responsive gene expression in whole plants. Plant J. 5, 559-569.
38. WHALEN, J.D., LECHMAN, E.L., CARLOS, C.A., WEISS, K., KOVESDI, I., GLORIOSO, J.C., ROBBINS, P.D., and EVANS, C.H. (1999). Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. J. Immunol. 162, 3625-3632.
39. ZENG, Q., TAN, Y.H., and HONG, W. (1998). A single plasmid vector (pSTAR) mediating efficient tetracycline-induced gene expression. Anal. Biochem. 259, 187-194.
40. ZHENG, T., ZHU, Z., WANG, Z., HOMER, R.J., MA, B., RIESE, R.J., JR., CHAPMAN, H.A., JR., SHAPIRO, S.D., and ELIAS, J.A. (2000). Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J. Clin. Invest. 106, 1081-1093.
41. ZHU, Z., MA, B., HOMER, R.J., ZHENG, T., and ELIAS, J.A. (2001). Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J. Biol. Chem. 276, 25222-25229.