Structure and function in rhodopsin: Packing of the helices in the transmembrane domain and folding to a tertiary structure in the intradiscal domain are coupled

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 20, 1997, Pages 10571-10576

  Hwa, John ^a   Garriga, Pere ^a,b   Liu, Xun ^a,c   Khorana, H Gobind ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^c CytoMed Inc   (United States)

Author keywords

11 cis retinal; Disulfide bond; G protein coupled receptor; Metarhodopsin II; Signal transduction

Indexed keywords

CYSTEINE; DISULFIDE; MUTANT PROTEIN; OPSIN; RHODOPSIN;

ARTICLE; CONTROLLED STUDY; DISULFIDE BOND; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; RETINITIS PIGMENTOSA; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; COS CELLS; DISULFIDES; MOLECULAR SEQUENCE DATA; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RHODOPSIN;

STAPHYLOCOCCUS PHAGE 187;

EID: 0030931599     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.20.10571     Document Type: Article

References (27)

1. Thurmond, R. L., Creuzenet, C., Reeves, P. J. & Khorana, H. G. (1997) Proc. Natl. Acad. Sci. USA 94, 1715-1720.
2. Berson, E. L. (1993) Invest. Ophthalmol. Vis. Sci. 34, 1659-1676.
3. Dryja, T. P. & Berson, E. L. (1995) Invest. Ophthalmol. Vis. Sci. 36, 1197-1200.
4. Sung, C.-H., Davenport, C. M., Hennessey, J. C., Maumenee, I. H., Jacobson, S. G., Heckenlively, J. R., Nowakowski, R., Fishman, G., Gouras, P. & Nathans, J. (1991) Proc. Natl. Acad. Sci. USA 88, 6481-6485.
5. Macke, J. P., Davenport, C. M., Jacobson, S. G., Hennessey, J. C., Gonzalez-Fernandez, F., Conway, B. P., Heckenlively, J., Palmer, R., Maumenee, I. H., Sieving, P., Gouras, P., Good, W. & Nathans, J. (1993) Am. J. Hum. Genet. 53, 80-89.
6. Inglehearn, C. F., Keen, T. J., Bashir, R., Jay, M., Fitzke. F., Bird, A. C., Crombie, A. & Bhattacharya, S. S. (1992) Hum. Mol. Genet. 1, 41-45.
7. Doi, T., Molday, R. S. & Khorana, H. G. (1990) Proc. Natl. Acad. Sci. USA 87, 4991-4995.
8. Anukanth, A. & Khorana, H. G. (1994) J. Biol. Chem. 269, 19738-19744.
9. Liu, X., Garriga, P. & Khorana, H. G. (1996) Proc. Natl. Acad. Sci. USA 93, 4554-4559.
10. Ridge, K. D., Lu, Z., Liu, X. & Khorana, H. G. (1995) Biochemistry 34, 3261-3267.
11. Garriga, P., Liu, X. & Khorana, H. G. (1996) Proc. Natl. Acad. Sci. USA 93, 4560-4564.
12. Dryja, T. P., Hahn, L. B., Cowley, G. S., McGee, T. L. & Berson, E. L. (1991) Proc. Natl. Acad. Sci. USA 88, 9370-9374.
13. Fuchs, S., Kranich, H., Denton, M. J., Zrenner, E., Bhattacharya, S. S., Humphries, P. & Gal, A. (1994) Hum. Mol. Genet. 3, 1203.
14. Sung, C., Davenport, C. M. & Nathans, J. (1993) J. Biol. Chem. 268, 26645-26649.
15. Souied, E., Gerber, S., Rozet, J., Bonneau, D., Dufier, J., Ghazi, I., Philip, N., Soubrane, G., Coscas, G., Munnich, A. & Kaplan, J. (1994) J. Hum. Mol. Genet. 3, 1433-1434.
16. Oprian, D. D., Molday, R. S., Kaufman R. J. & Khorana H. G. (1987) Proc. Natl. Acad. Sci. USA 84, 8874-8878.
17. Ferretti, L., Karnik, S. S., Khorana, H. G., Nassal, M. & Oprian, D. D. (1986) Proc. Natl. Acad. Sci. USA 83, 599-603.
18. Franke, R. R., Sakmar, T. P., Oprian, D. D. & Khorana H. G. (1988) J. Biol. Chem. 267, 2119-2122.
19. Sanger, F., Nicklen, S. & Coulson, A. R. (1977) Proc. Natl. Acad. Sci. USA 74, 5463-5467.
20. Sakmar, T. P., Franke, R. R. & Khorana, H. G. (1989) Proc. Natl. Acad. Sci. USA 86, 8309-8313.
21. Farrens, D. L. & Khorana, H. G. (1995) J. Biol. Chem. 270, 5073-5076.
22. Hong, K., Knudsen, P. J. & Hubbell, W. L. (1982) Methods Enzymol. 81, 144-150.
23. Kaushal, S. & Khorana, H. G. (1994) Biochemistry 33, 6121-6128.
24. Karnik, S. S., Sakmar, T. P., Chen, H.-B. & Khorana, H. (1998) Proc. Natl. Acad. Sci. USA 85, 8459-8463.
25. Karnik, S. S. & Khorana. H. G. (1990) J. Biol. Chem. 265, 17520-17524.
26. Davidson, F. F., Loewen, P. C. & Khorana, H. G. (1994) Proc. Natl. Acad. Sci. USA 91, 4029-4033.
27. Kaushal, S., Ridge, K. D. & Khorana, H. G. (1994) Proc. Natl. Acad. Sci. USA 91, 4024-4028.