New movements in neurofilament transport, turnover and disease

Experimental Cell Research

Volumn 313, Issue 10, 2007, Pages 2110-2120

  Barry, Devin M ^a   Millecamps, Stephanie ^b   Julien, Jean Pierre ^c   Garcia, Michael L ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b CNRS   (France)

^c UNIVERSITÉ LAVAL   (Canada)

Author keywords

Charcot Marie Tooth; CMT; Disease; Intermediate filament; Motor Neuron; Neurofilament; Neuropathology; Phosphorylation; Transport; Turnover

Indexed keywords

ALPHA INTERNEXIN; DYNEIN ADENOSINE TRIPHOSPHATASE; KINESIN; NEUROFILAMENT PROTEIN;

CARBOXY TERMINAL SEQUENCE; CELL TRANSPORT; CELL VACUOLE; CENTRAL NERVOUS SYSTEM; CYTOSKELETON; DENSITOMETRY; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; INTERMEDIATE FILAMENT; MOTONEURON; NERVE CELL DEGENERATION; NEUROFILAMENT; NEUROPATHY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; REVIEW; STOICHIOMETRY; TRANSGENE; TRANSGENIC MOUSE;

EID: 34249798456     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2007.03.011     Document Type: Review

References (104)

1. Lasek R.J. Bidirectional transport of radioactively labelled axoplasmic components. Nature 216 (1967) 1212-1214
2. Hoffman P.N., and Lasek R.J. The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons. J. Cell Biol. 66 (1975) 351-366
3. Yuan A., Rao M.V., Sasaki T., Chen Y., Kumar A., Veeranna R.K.H., Liem J., Eyer A.C., Peterson J.-P., and Julien R.A. {alpha}-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. J. Neurosci. 26 (2006) 10006-10019
4. Shah J.V., Flanagan L.A., Janmey P.A., and Leterrier J.F. Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol. Biol. Cell 11 (2000) 3495-3508
5. Yuan A., Nixon R.A., and Rao M.V. Deleting the phosphorylated tail domain of the neurofilament heavy subunit does not alter neurofilament transport rate in vivo. Neurosci. Lett. 393 (2006) 264-268
6. Ching G.Y., and Liem R.K. Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments. J. Cell Biol. 122 (1993) 1323-1335
7. Lee M.K., Xu Z., Wong P.C., and Cleveland D.W. Neurofilaments are obligate heteropolymers in vivo. J. Cell Biol. 122 (1993) 1337-1350
8. Scott D., Smith K.E., O'Brien B.J., and Angelides K.J. Characterization of mammalian neurofilament triplet proteins. Subunit stoichiometry and morphology of native and reconstituted filaments. J. Biol. Chem. 260 (1985) 10736-10747
9. Fuchs E., and Weber K. Intermediate filaments: structure, dynamics, function, and disease. Annu. Rev. Biochem. 63 (1994) 345-382
10. Lee M.K., and Cleveland D.W. Neuronal intermediate filaments. Annu. Rev. Neurosci. 19 (1996) 187-217
11. Wong P.C., and Cleveland D.W. Characterization of dominant and recessive assembly-defective mutations in mouse neurofilament NF-M. J. Cell Biol. 111 (1990) 1987-2003
12. Sihag R.K., and Nixon R.A. Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport. J. Biol. Chem. 266 (1991) 18861-18867
13. Dong D.L., Xu Z.S., Chevrier M.R., Cotter R.J., Cleveland D.W., and Hart G.W. Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M. J. Biol. Chem. 268 (1993) 16679-16687
14. Hirokawa N., Glicksman M.A., and Willard M.B. Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton. J. Cell Biol. 98 (1984) 1523-1536
15. Hisanaga S., and Hirokawa N. Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing. J. Mol. Biol. 202 (1988) 297-305
16. Julien J.P., and Mushynski W.E. Multiple phosphorylation sites in mammalian neurofilament polypeptides. J. Biol. Chem. 257 (1982) 10467-10470
17. Julien J.P., and Mushynski W.E. The distribution of phosphorylation sites among identified proteolytic fragments of mammalian neurofilaments. J. Biol. Chem. 258 (1983) 4019-4025
18. Garcia M.L., Lobsiger C.S., Shah S.B., Deerinck T.J., Crum J., Young D., Ward C.M., Crawford T.O., Gotow T., Uchiyama Y., Ellisman M.H., Calcutt N.A., and Cleveland D.W. NF-M is an essential target for the myelin-directed "outside-in" signaling cascade that mediates radial axonal growth. J. Cell Biol. 163 (2003) 1011-1020
19. Jacomy H., Zhu Q., Couillard-Després S., Beaulieu J.M., and Julien J.P. Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits. J. Neurochem. 73 (1999) 972-984
20. Levavasseur F., Zhu Q., and Julien J.P. No requirement of alpha-internexin for nervous system development and for radial growth of axons. Brain Res. Mol. Brain Res. 69 (1999) 104-112
21. Yuan A., Rao M.V., Kumar A., Julien J.P., and Nixon R.A. Neurofilament transport in vivo minimally requires hetero-oligomer formation. J. Neurosci. 23 (2003) 9452-9458
22. Grafstein B., and Forman D.S. Intracellular transport in neurons. Physiol. Rev. 60 (1980) 1167-1283
23. Wang L., Ho C.L., Sun D., Liem R.K., and Brown A. Rapid movement of axonal neurofilaments interrupted by prolonged pauses. Nature Cell Biology 2 (2000) 137-141
24. Roy S., Coffee P., Smith G., Liem R.K., Brady S.T., and Black M.M. Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport. J. Neurosci. 20 (2000) 6849-6861
25. Shea T.B., and Flanagan L.A. Kinesin, dynein and neurofilament transport. Trends Neurosci. 24 (2001) 644-648
26. Yabe J.T., Pimenta A., and Shea T.B. Kinesin-mediated transport of neurofilament protein oligomers in growing axons. J. Cell. Sci. 112 (1999) 3799-3814
27. Yabe J.T., Jung C., Chan W.K., and Shea T.B. Phospho-dependent association of neurofilament proteins with kinesin in situ. Cell Motil. Cytoskelet. 45 (2000) 249-262
28. Xia C.H., Roberts E.A., Her L.S., Liu X., Williams D.S., Cleveland D.W., and Goldstein L.S. Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J. Cell Biol. 161 (2003) 55-66
29. Wang L., and Brown A. Rapid intermittent movement of axonal neurofilaments observed by fluorescence photobleaching. Mol. Biol. Cell 12 (2001) 3257-3267
30. McEwen B.S., and Grafstein B. Fast and slow components in axonal transport of protein. J. Cell Biol. 38 (1968) 494-508
31. LaMonte B.H., Wallace K.E., Holloway B.A., Shelly S.S., Ascano J., Tokito M., Van Winkle T., Howland D.S., and Holzbaur E.L. Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron 34 (2002) 715-727
32. Jung C., Lee S., Ortiz D., Zhu Q., Julien J.P., and Shea T.B. The high and middle molecular weight neurofilament subunits regulate the association of neurofilaments with kinesin: inhibition by phosphorylation of the high molecular weight subunit. Brain Res. Mol. Brain Res. 141 (2005) 151-155
33. Wagner O.I., Ascano J., Tokito M., Leterrier J.F., Janmey P.A., and Holzbaur E.L. The interaction of neurofilaments with the microtubule motor cytoplasmic dynein. Mol. Biol. Cell 15 (2004) 5092-5100
34. Zhu Q., Lindenbaum M., Levavasseur F., Jacomy H., and Julien J.P. Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile. J. Cell Biol. 143 (1998) 183-193 (see comments)
35. Rao M.V., Garcia M.L., Miyazaki Y., Gotow T., Yuan A., Mattina S., Ward C.M., Calcutt N.A., Uchiyama Y., Nixon R.A., and Cleveland D.W. Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J. Cell Biol. 158 (2002) 681-693
36. Lewis S.E., and Nixon R.A. Multiple phosphorylated variants of the high molecular mass subunit of neurofilaments in axons of retinal cell neurons: characterization and evidence for their differential association with stationary and moving neurofilaments. J. Cell Biol. 107 (1988) 2689-2701
37. Rao M.V., Campbell J., Yuan A., Kumar A., Gotow T., Uchiyama Y., and Nixon R.A. The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. J. Cell Biol. 163 (2003) 1021-1031
38. Sanchez I., Hassinger L., Paskevich P.A., Shine H.D., and Nixon R.A. Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. J. Neurosci. 16 (1996) 5095-5105
39. Sanchez I., Hassinger L., Sihag R.K., Cleveland D.W., Mohan P., and Nixon R.A. Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. J. Cell Biol. 151 (2000) 1013-1024
40. Ackerley S., Thornhill P., Grierson A.J., Brownlees J., Anderton B.H., Leigh P.N., Shaw C.E., and Miller C.C. Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments. J. Cell Biol. 161 (2003) 489-495
41. Shea T.B., Jung C., and Pant H.C. Does neurofilament phosphorylation regulate axonal transport?. Trends Neurosci. 26 (2003) 397-400
42. Nixon R., Paskevich P., Sihag R., and Thayer C. Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber. J. Cell Biol. 126 (1994) 1031-1046
43. de Waegh S.M., Lee V.M., and Brady S.T. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell 68 (1992) 451-463
44. Nixon R.A., and Logvinenko K.B. Multiple fates of newly synthesized neurofilament proteins: evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons. J. Cell Biol. 102 (1986) 647-659
45. Tremblay P., Meiner Z., Galou M., Heinrich C., Petromilli C., Lisse T., Cayetano J., Torchia M., Mobley W., Bujard H., DeArmond S.J., and Prusiner S.B. Doxycycline control of prion protein transgene expression modulates prion disease in mice. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 12580-12585
46. Hirano A., Donnenfeld H., Sasaki S., and Nakano I. Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 43 (1984) 461-470
47. Hirano A., Nakano I., Kurland L.T., Mulder D.W., Holley P.W., and Saccomanno G. Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 43 (1984) 471-480
48. Corbo M., and Hays A.P. Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease. J. Neuropathol. Exp. Neurol. 51 (1992) 531-537
49. Carpenter S. Proximal axonal enlargement in motor neuron disease. Neurology 18 (1968) 841-851
50. Beaulieu J.M., Nguyen M.D., and Julien J.P. Late onset death of motor neurons in mice overexpressing wild-type peripherin. J. Cell Biol. 147 (1999) 531-544
51. Beaulieu J.M., and Julien J.P. Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteins. J. Neurochem. 85 (2003) 248-256
52. Asbury A.K., Gale M.K., Cox S.C., Baringer J.R., and Berg B.O. Giant axonal neuropathy-A unique case with segmental neurofilamentous masses. Acta Neuropathol. (Berl) 20 (1972) 237-247
53. Bomont P., Cavalier L., Blondeau F., Ben Hamida C., Belal S., Tazir M., Demir E., Topaloglu H., Korinthenberg R., Tuysuz B., Landrieu P., Hentati F., and Koenig M. The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy. Nat. Genet. 26 (2000) 370-374
54. Cairns N.J., Uryu K., Bigio E.H., Mackenzie I.R., Gearing M., Duyckaerts C., Yokoo H., Nakazato Y., Jaros E., Perry R.H., Arnold S.E., Lee V.M., and Trojanowski J.Q. alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Acta Neuropathol. (Berl) 108 (2004) 213-223
55. Bergeron C., Muntasser S., Somerville M.J., Weyer L., and Percy M.E. Copper/zinc superoxide dismutase mRNA levels are increased in sporadic amyotrophic lateral sclerosis motorneurons. Brain Res. 659 (1994) 272-276
56. Wong N.K., He B.P., and Strong M.J. Characterization of neuronal intermediate filament protein expression in cervical spinal motor neurons in sporadic amyotrophic lateral sclerosis (ALS). J. Neuropathol. Exp. Neurol. 59 (2000) 972-982
57. Menzies F.M., Grierson A.J., Cookson M.R., Heath P.R., Tomkins J., Figlewicz D.A., Ince P.G., and Shaw P.J. Selective loss of neurofilament expression in Cu/Zn superoxide dismutase (SOD1) linked amyotrophic lateral sclerosis. J. Neurochem. 82 (2002) 1118-1128
58. Canete-Soler R., Wu J., Zhai J., Shamim M., and Schlaepfer W.W. p190RhoGEF Binds to a destabilizing element in the 3′ untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript. J. Biol. Chem. 276 (2001) 32046-32050
59. Nie Z., Wu J., Zhai J., Lin H., Ge W., Schlaepfer W.W., and Canete-Soler R. Untranslated element in neurofilament mRNA has neuropathic effect on motor neurons of transgenic mice. J. Neurosci. 22 (2002) 7662-7670
60. Cote F., Collard J.F., and Julien J.P. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell 73 (1993) 35-46
61. Gama Sosa M.A., Friedrich Jr. V.L., DeGasperi R., Kelley K., Wen P.H., Senturk E., Lazzarini R.A., and Elder G.A. Human midsized neurofilament subunit induces motor neuron disease in transgenic mice. Exp. Neurol. 184 (2003) 408-419
62. Xu Z., Cork L.C., Griffin J.W., and Cleveland D.W. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 73 (1993) 23-33
63. Wong P.C., Marszalek J., Crawford T.O., Xu Z., Hsieh S.T., Griffin J.W., and Cleveland D.W. Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J. Cell Biol. 130 (1995) 1413-1422
64. Lee M.K., Marszalek J.R., and Cleveland D.W. A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 13 (1994) 975-988
65. Al-Chalabi A., Andersen P.M., Nilsson P., Chioza B., Andersson J.L., Russ C., Shaw C.E., Powell J.F., and Leigh P.N. Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis. Hum. Mol. Genet. 8 (1999) 157-164
66. Figlewicz D.A., Krizus A., Martinoli M.G., Meininger V., Dib M., Rouleau G.A., and Julien J.P. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum. Mol. Genet. 3 (1994) 1757-1761
67. Garcia M.L., Singleton A.B., Hernandez D., Ward C.M., Evey C., Sapp P.A., Hardy J., Brown Jr. R.H., and Cleveland D.W. Mutations in neurofilament genes are not a significant primary cause of non-SOD1-mediated amyotrophic lateral sclerosis. Neurobiol. Dis. 21 (2006) 102-109
68. Rooke K., Figlewicz D.A., Han F.Y., and Rouleau G.A. Analysis of the KSP repeat of the neurofilament heavy subunit in familiar amyotrophic lateral sclerosis. Neurology 46 (1996) 789-790
69. Tomkins J., Usher P., Slade J.Y., Ince P.G., Curtis A., Bushby K., and Shaw P.J. Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS). Neuroreport 9 (1998) 3967-3970
70. Vechio J.D., Bruijn L.I., Xu Z., Brown Jr. R.H., and Cleveland D.W. Sequence variants in human neurofilament proteins: absence of linkage to familial amyotrophic lateral sclerosis. Ann. Neurol. 40 (1996) 603-610
71. Leung C.L., He C.Z., Kaufmann P., Chin S.S., Naini A., Liem R.K., Mitsumoto H., and Hays A.P. A pathogenic peripherin gene mutation in a patient with amyotrophic lateral sclerosis. Brain Pathol. 14 (2004) 290-296
72. Gros-Louis F., Lariviere R., Gowing G., Laurent S., Camu W., Bouchard J.P., Meininger V., Rouleau G.A., and Julien J.P. A frameshift deletion in peripherin gene associated with amyotrophic lateral sclerosis. J. Biol. Chem. 279 (2004) 45951-45956
73. Robertson J., Doroudchi M.M., Nguyen M.D., Durham H.D., Strong M.J., Shaw G., Julien J.P., and Mushynski W.E. A neurotoxic peripherin splice variant in a mouse model of ALS. J. Cell Biol. 160 (2003) 939-949
74. Bertorini T., Narayanaswami P., and Rashed H. Charcot-Marie-Tooth disease (hereditary motor sensory neuropathies) and hereditary sensory and autonomic neuropathies. Neurologist 10 (2004) 327-337
75. Mersiyanova I.V., Perepelov A.V., Polyakov A.V., Sitnikov V.F., Dadali E.L., Oparin R.B., Petrin A.N., and Evgrafov O.V. A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet. 67 (2000) 37-46
76. De Jonghe P., Mersivanova I., Nelis E., Del Favero J., Martin J.J., Van Broeckhoven C., Evgrafov O., and Timmerman V. Further evidence that neurofilament light chain gene mutations can cause Charcot-Marie-Tooth disease type 2E. Ann. Neurol. 49 (2001) 245-249
77. Georgiou D.M., Zidar J., Korosec M., Middleton L.T., Kyriakides T., and Christodoulou K. A novel NF-L mutation Pro22Ser is associated with CMT2 in a large Slovenian family. Neurogenetics 4 (2002) 93-96
78. Yoshihara T., Yamamoto M., Hattori N., Misu K., Mori K., Koike H., and Sobue G. Identification of novel sequence variants in the neurofilament-light gene in a Japanese population: analysis of Charcot-Marie-Tooth disease patients and normal individuals. J. Peripher. Nerv. Syst. 7 (2002) 221-224
79. Jordanova A., De Jonghe P., Boerkoel C.F., Takashima H., De Vriendt E., Ceuterick C., Martin J.J., Butler I.J., Mancias P., Papasozomenos S., Terespolsky D., Potocki L., Brown C.W., Shy M., Rita D.A., Tournev I., Kremensky I., Lupski J.R., and Timmerman V. Mutations in the neurofilament light chain gene (NEFL) cause early onset severe Charcot-Marie-Tooth disease. Brain 126 (2003) 590-597
80. Zuchner S., Vorgerd M., Sindern E., and Schroder J.M. The novel neurofilament light (NEFL) mutation Glu397Lys is associated with a clinically and morphologically heterogeneous type of Charcot-Marie-Tooth neuropathy. Neuromuscul. Disord. 14 (2004) 147-157
81. Choi B.O., Lee M.S., Shin S.H., Hwang J.H., Choi K.G., Kim W.K., Sunwoo I.N., Kim N.K., and Chung K.W. Mutational analysis of PMP22, MPZ, GJB1, EGR2 and NEFL in Korean Charcot-Marie-Tooth neuropathy patients. Human Mutat. 24 (2004) 185-186
82. Fabrizi G.M., Cavallaro T., Angiari C., Cabrini I., Taioli F., Malerba G., Bertolasi L., and Rizzuto N. Charcot-Marie-Tooth disease type 2E, a disorder of the cytoskeleton. Brain 130 (2007) 394-403
83. Brownlees J., Ackerley S., Grierson A.J., Jacobsen N.J., Shea K., Anderton B.H., Leigh P.N., Shaw C.E., and Miller C.C. Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport. Hum. Mol. Genet. 11 (2002) 2837-2844
84. Perez-Olle R., Leung C.L., and Liem R.K. Effects of Charcot-Marie-Tooth-linked mutations of the neurofilament light subunit on intermediate filament formation. J. Cell Sci. 115 (2002) 4937-4946
85. Perez-Olle R., Jones S.T., and Liem R.K. Phenotypic analysis of neurofilament light gene mutations linked to Charcot-Marie-Tooth disease in cell culture models. Hum. Mol. Genet. 13 (2004) 2207-2220
86. Perez-Olle R., Lopez-Toledano M.A., Goryunov D., Cabrera-Poch N., Stefanis L., Brown K., and Liem R.K. Mutations in the neurofilament light gene linked to Charcot-Marie-Tooth disease cause defects in transport. J. Neurochem. 93 (2005) 861-874
87. Sasaki T., Gotow T., Shiozaki M., Sakaue F., Saito T., Julien J.-P., Uchiyama Y., and Hisanaga S.-I. Aggregate formation and phosphorylation of neurofilament-L Pro22 Charcot-Marie-Tooth disease mutants. Hum. Mol. Genet. 15 (2006) 943-952
88. Fabrizi G.M., Cavallaro T., Angiari C., Bertolasi L., Cabrini I., Ferrarini M., and Rizzuto N. Giant axon and neurofilament accumulation in Charcot-Marie-Tooth disease type 2E. Neurology 62 (2004) 1429-1431
89. Kelly B.M., Gillespie C.S., Sherman D.L., and Brophy P.J. Schwann cells of the myelin-forming phenotype express neurofilament protein NF-M. J. Cell Biol. 118 (1992) 397-410
90. Fabrizi C., Kelly B.M., Gillespie C.S., Schlaepfer W.W., Scherer S.S., and Brophy P.J. Transient expression of the neurofilament proteins NF-L and NF-M by Schwann cells is regulated by axonal contact. J. Neurosci. Res. 50 (1997) 291-299
91. Zhao C., Takita J., Tanaka Y., Setou M., Nakagawa T., Takeda S., Yang H.W., Terada S., Nakata T., Takei Y., Saito M., Tsuji S., Hayashi Y., and Hirokawa N. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta. Cell 105 (2001) 587-597
92. Reid E., Kloos M., Ashley-Koch A., Hughes L., Bevan S., Svenson I.K., Graham F.L., Gaskell P.C., Dearlove A., Pericak-Vance M.A., Rubinsztein D.C., and Marchuk D.A. A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am. J. Hum. Genet. 71 (2002) 1189-1194
93. Marszalek J.R., Williamson T.L., Lee M.K., Xu Z., Hoffman P.N., Becher M.W., Crawford T.O., and Cleveland D.W. Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. J. Cell Biol. 135 (1996) 711-724
94. Zhu Q., Couillard-Després S., and Julien J.P. Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp. Neurol. 148 (1997) 299-316
95. Xu Z., Marszalek J.R., Lee M.K., Wong P.C., Folmer J., Crawford T.O., Hsieh S.T., Griffin J.W., and Cleveland D.W. Subunit composition of neurofilaments specifies axonal diameter. J. Cell Biol. 133 (1996) 1061-1069
96. Xu Z., and Tung V.W. Overexpression of neurofilament subunit M accelerates axonal transport of neurofilaments. Brain Res. 866 (2000) 326-332
97. Elder G.A., Friedrich Jr. V.L., Kang C., Bosco P., Gourov A., Tu P.H., Zhang B., Lee V.M., and Lazzarini R.A. Requirement of heavy neurofilament subunit in the development of axons with large calibers. J. Cell Biol. 143 (1998) 195-205 (Comment In: J. Cell Biol. 1998 Oct 5;143(1):1-4)
98. Rao M.V., Houseweart M.K., Williamson T.L., Crawford T.O., Folmer J., and Cleveland D.W. Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation. J. Cell Biol. 143 (1998) 171-181 (see comments)
99. Elder G.A., Friedrich Jr. V.L., Bosco P., Kang C., Gourov A., Tu P.H., Lee V.M., and Lazzarini R.A. Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content. J. Cell Biol. 141 (1998) 727-739
100. Elder G.A., Friedrich V.L., Margita A., and Lazzarini R.A. Age-related atrophy of motor axons in mice deficient in the mid-sized neurofilament subunit. J. Cell Biol. 146 (1999) 181-192
101. Elder G.A., Friedrich Jr. V.L., Pereira D., Tu P.H., Zhang B., Lee V.M., and Lazzarini R.A. Mice with disrupted midsized and heavy neurofilament genes lack axonal neurofilaments but have unaltered numbers of axonal microtubules. J. Neurosci. Res. 57 (1999) 23-32
102. Letournel F., Bocquet A., Perrot R., Dechaume A., Guinut F., Eyer J., and Barthelaix A. Neurofilament high molecular weight-green fluorescent protein fusion is normally expressed in neurons and transported in axons: a neuronal marker to investigate the biology of neurofilaments. Neuroscience 137 (2006) 103-111
103. Millecamps S., Robertson J., Lariviere R., Mallet J., and Julien J.P. Defective axonal transport of neurofilament proteins in neurons overexpressing peripherin. J. Neurochem. 98 (2006) 926-938
104. Eyer J., and Peterson A. Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-beta-galactosidase fusion protein. Neuron 12 (1994) 389-405