Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content

Journal of Cell Biology

Volumn 141, Issue 3, 1998, Pages 727-739

  Elder, Gregory A ^a   Friedrich Jr , Victor L ^a   Bosco, Paolo ^a   Kang, Chulho ^a   Gourov, Andrei ^a   Tu, Pang Hsien ^b   Lee, Virginia M Y ^b   Lazzarini, Robert A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICROTUBULE PROTEIN; NEUROFILAMENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENOTYPE; INTERMEDIATE FILAMENT; MALE; MICROTUBULE ASSEMBLY; MOUSE; MYELINATION; NERVE FIBER; NEUROFILAMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONTENT; REGULATOR GENE;

ANIMALS; AXONS; CELL LINE; GENE DELETION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROFILAMENT PROTEINS; PHENOTYPE;

EID: 0032482231     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.141.3.727     Document Type: Article

References (45)

1. Berthold, C.-H. 1978. Morphology of normal peripheral axons. In Physiology and Pathobiology of Axons. S.G. Waxman, editor. Raven Press, New York. 3-63.
2. Bradley, A. 1987. Production and analysis of chimaeric mice. In Teratocarcinomas and Embryonic Stem Cells: A Practical Approach. E.J. Robertson, editor. IRL Press, Washington, DC. 113-151.
3. Burgoyne, R.D., and M.A. Cambray-Deakin. 1988. The cellular neurobiology of neuronal development: the cerebellar granule cell. Brain Res. Rev. 13:77-101.
4. Carden, M.J., J.Q. Trojanowski, W.W. Schleapfer, and V.M.-Y. Lee. 1987. Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation. J. Neurosci. 7:3489-3504.
5. Ching, G., and R. Liem. 1993. Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments. J Cell Biol. 122:1323-1335.
6. de Waegh, S., V.M. Lee, and S.T. Brady. 1992. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell. 68:451-463.
7. Elder, G.A., V.L. Friedrich, Z. Liang, X. Li, and R.A. Lazzarini. 1994. Enhancer trapping by a human mid-sized neurofilament transgene reveals unexpected patterns of neuronal enhancer activity. Mol. Brain Res. 26:177-188.
8. Eyer, J., and A. Peterson. 1994. Neurofilament-deficient axons and perikaryal aggregates in viable transgenic mice expressing a neurofilament-β-galactosidase fusion protein. Neuron. 12:389-405.
9. Friede, R., and T. Sarnorajski. 1970. Axon caliber related to neurofilaments and microtubules in sciatic nerve. Anat. Rec. 167:379-388.
10. Friedrich, V.L.J., and E. Mugnaini. 1981. Preparation of neural tissues for electron microscopy. In A Handbook of Neuroanatomical Tract Tracing Techniques. Plenum Press, New York. 377-406.
11. Hirokawa, N. 1982. Cross-linker system between neurofilaments, microtubules, and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method. J. Cell Biol. 94:129-142.
12. Hirokawa, N., M.A. Glicksman, and M.B. Willard. 1984. Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton. J. Cell Biol. 98:1523-1536.
13. Hisanaga, S., and N. Hirokawa. 1988. Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing. J. Mol. Biol. 202:297-305.
14. Hoffman, P.N., J.W. Griffin, and D.L. Price. 1984. Control of axonal caliber by neurofilament transport. J. Cell Biol. 99:705-714.
15. Huffman, P.N., G.W. Thompson, J. W. Griffin, and D.L. Price. 1985. Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers. J. Cell Biol. 101: 1332-1340.
16. Hoffman, P.N., E.H. Koo, N.A. Muma, J.W. Griffin, and D.L. Price. 1988. Role of neurofilaments in the control of axonal caliber in myelinated nerve fibers. In Intrinsic Determinants of Neuronal Form and Function. Vol. 37. R.J. Lasek and M.M. Black, editors. Alan R. Liss, New York, NY. 389-402.
17. Julien, J.-P., D. Meyer, D. Flavell, J. Hurst, and F. Grosveld. 1986. Cloning and developmental expression of the murine neurofilament gene family Mol. Brain Res. 1:243-250.
18. Kaplan, M.P., S.S. Chin, P. Macioce, J. Srinawasan, G. Hashim, and R.K. Liem. 1991. Characterization of a panel of neurofilament antibodies recognizing N-terminal epitopes. J. Neurosci. Res. 30:545-554.
19. Lasek, R.J., M.M. Oblinger, and P.F. Drake. 1983. Molecular biology of neuronal geometry: expression of neurofilament genes influences axonal diameter. Cold Spring Harbor Symp. Quant. Biol. 48:731-744.
20. Lee, M., Z. Xu, P. Wong, and D. Cleveland. 1993. Neurofilaments are obligate heteropolymers in vivo. J. Cell Biol. 122:1337-1350.
21. Lees, J.F., P.S. Shneidman, S.F. Skuntz, M.J. Carden, and R.A. Lazzarini. 1988. The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it. EMBO (Ear. Mol. Biol. Organ.) J. 7:1947-1955.
22. Levy, E., R.K.H. Liem, P. D'Eustachio, and N.J. Cowan. 1987. Structure and evolutionary origin of the gene encoding mouse NF-M, the middle-molecular-mass neurofilament protein. Eur. J. Biochem. 166:71-77.
23. Mansour, S.L., K.R. Thomas, and M.R. Capecchi. 1988. Disruption of the proto-oncogene int-2 in mouse-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature. 336:348-352.
24. Matus, A. 1988. Neurofilament protein phosphorylation-where, when and why. Trends Neurosci. 11:291-292.
25. Monteiro, M.J., P.N. Hoffman, J.D. Gearhart, and D.W. Cleveland. 1990. Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J. Cell Biol. 111:1543-1557.
26. Mulligan, L., B.J. Balin, V.M.-Y. Lee, and W.P. Ip. 1991. Antibody labeling of bovine neurofilaments: implications on the structure of neurofilament sidearms. J. Struct. Biol. 106:145-160.
27. Myers, M.W., R.A. Lazzarini, V.M.-Y. Lee, W.W. Schlaepfer, and D.L. Nelson. 1987. The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family. EMBO (Eur. Mol. Biol. Organ.) J. 6:1617-1626.
28. Nagy, A., J. Rossant, R. Nagy, W. Abranow-Newerly, and J.C. Roder. 1993. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA. 90:8424-8428.
29. Nakagawa, T., J. Chen, Z. Zhang, Y. Kanai, and N. Hirokawa. 1995. The distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: cross-bridge formation and longitudinal elongation of filaments. J. Cell Biol. 129:411-429.
30. Nixon, R.A. 1993. The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathology. Brain Pathol. 3:29-38.
31. Ohara, O., Y. Gahara, T. Miyake, H. Teraoka, and T. Kitamura. 1993. Neurofilament deficiency in quail caused by nonsense mutation in neurofilament-L gene. J. Cell Biol. 121:387-395.
32. Palay, S.L., and V. Chan-Palay. 1974. Cerebellar Cortex Cytology and Organization. Springer, Berlin. 348 pp.
33. Parry, D.A.D. 1990. Primary and secondary structure of IF protein chains and models of molecular aggregation. In Cellular and Molecular Biology of Intermediate Filaments. R.D. Goldman and P.M. Steinert, editors. Plenum Press. New York. 175-204.
34. Peters, A., and J.E. Vaughn. 1967. Microtubules and filaments in the axons and astrocytes of early postnatal rat optic nerves. J. Cell Biol. 32:113-119.
35. Price, R.L., P. Paggi, R.J. Lasek, and M.J. Katz. 1988. Neurofilaments are spaced randomly in the radial dimension of axons. J. Neurocytol. 17:55-62.
36. Robertson, E.J. 1987. Embryo derived stem cell lines. In Teratocarcinomas and Embryonic Stem Cells: A Practical Approach. E.J. Robertson, editor. IRL Press, Washington, DC. 71-112.
37. Sakaguchi, T., M. Okada, T. Kitarnura, and K. Kawasaki. 1993. Reduced diameter and conduction velocity of myelinated fibers in the sciatic nerve of a neurofilament-deficient mutant quail. Neurosci. Lett. 153:65-68.
38. Trojanowski, J.Q., N. Walkenstein, and A.M.-Y. Lee. 1986, Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies. J. Neurosci. 6:650-660.
39. Tu, P.-H., G. Elder, R.A. Lazzarini, D. Nelson, J.Q. Trojanowski, and V.M.-Y. Lee. 1995. Overexpression of the human NFM subunil in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits. J. Cell Biol. 129:1629-1640.
40. Wong, P.C., J. Marszalek, T.O. Crawford, Z. Xu, S.-T. Hsieh, J.W. Griffin, and D.W. Cleveland. 1995. Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J. Cell Biol. 130:1413-1422.
41. Wuerker, R.B., and J.B. Kirkpatrick. 1972. Neurofilaments and microtubules in anterior horn cells of the rat. Int. Rev. Cytol. 33:45-75.
42. Wurst, W., and A.L. Joyner. 1993. Production of targeted embryonic stem cell clones. In Gene Targeting: A Practical Approach. A.L. Joyner, editor. IRL Press, New York. 33-61.
43. Xu, Z., J.R. Marszalek, M.K. Lee, P.C. Wong, J. Folmer, T.O. Crawford, S.-T. Hsieh, J.W. Griffin, and D.W. Cleveland. 1996. Subunit composition of neurofilaments specifies axonal diameter. J. Cell Biol 133:1061-1069.
44. Yamasaki, H., C. Itakura, and M. Mizutani. 1991. Hereditary hypotrophic axonopathy with neurofilament deficiency in a mutant strain of the Japanese quail. Acta Neuropathol. 82:427-434.
45. Zhu, Q., S. Couillard-Depres, and J.-P. Julien. 1997. Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments. Exp. Neurol. 148:299-316.