Discovery of 4-pyridone derivatives as specific inhibitors of enoyl-acyl carrier protein reductase (FabI) with antibacterial activity against Staphylococcus aureus

Journal of Antibiotics

Volumn 60, Issue 2, 2007, Pages 123-128

  Takahata, Sho ^a   Iida, Maiko ^a   Yoshida, Takuji ^a   Kumura, Ko ^a   Kitagawa, Hideo ^a   Hoshiko, Shigeru ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

4 pyridone; Enoyl acyl carrier protein reductase; FabI; Inhibitor; MRSA; Staphylococcus aureus

Indexed keywords

4 PYRIDONE DERIVATIVE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); LINEZOLID; TRICLOSAN; VANCOMYCIN; ANTIINFECTIVE AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR; PYRIDONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME INHIBITION; ESCHERICHIA COLI; IC 50; LIPOGENESIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; MICROBIOLOGICAL EXAMINATION; PENICILLIN RESISTANCE; SYNTHESIS;

ESCHERICHIA COLI; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; ESCHERICHIA COLI; INDICATORS AND REAGENTS; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; PYRIDONES; STAPHYLOCOCCUS AUREUS; TRICLOSAN;

EID: 34249739592     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.11     Document Type: Article

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