Identification and Characterization of Inhibitors of Bacterial Enoyl-Acyl Carrier Protein Reductase

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 5, 2004, Pages 1541-1547

  Ling, Losee L ^a   Xian, Jun ^a   Ali, Syed ^b   Geng, Bolin ^b   Fan, Jun ^a   Mills, Debra M ^a   Arvanites, Anthony C ^a   Orgueira, Hernan ^b   Ashwell, Mark A ^b   Carmel, Gilles ^a   Xiang, Yibin ^a   Moir, Donald T ^a,c  

^a GENOME THERAPEUTICS CORPORATION   (United States)

^b ARQULE INC   (United States)

^c MICROBIOTIX INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,6 DIPHENYLPYRIDINE 3 CARBONITRILE; ANTIINFECTIVE AGENT; ENOYL ACYL CARRIER PROTEIN REDUCTASE INHIBITOR; GTC 004061; GTC 096296; GTC 268724; GTC 268726; GTC 268733; GTC 268776; GTC 268847; GTC 268925; GTC 268963; GTC 330346; GTC 341772; GTC 343129; GTC 343130; GTC 343131; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CELL GROWTH; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; GROWTH INHIBITION; IC 50; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

BACILLUS SUBTILIS; BACTERIA; CLONING, MOLECULAR; DRUG EVALUATION, PRECLINICAL; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; ESCHERICHIA COLI; FATTY ACIDS; GENE EXPRESSION REGULATION, BACTERIAL; KINETICS; LAC OPERON; MICROBIAL SENSITIVITY TESTS; OXIDOREDUCTASES; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAPHYLOCOCCUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 11144356444     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.5.1541-1547.2004     Document Type: Article

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