A new calcineurin inhibition domain in Cabin1

Biochemical and Biophysical Research Communications

Volumn 359, Issue 1, 2007, Pages 129-135

  Jang, Hyonchol ^a   Cho, Eun Jung ^b   Youn, Hong Duk ^a  

^a Interdisciplinary Program in Genetic Engineering   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

Cabin1; Calcineurin; Calcineurin inhibition; Nuclear factor of activated T cells (NFAT)

Indexed keywords

AMINO ACID; CALCINEURIN; INTERLEUKIN 2; IONOMYCIN; TRANSCRIPTION FACTOR NFAT;

ARTICLE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR IMPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION;

CALCINEURIN; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; JURKAT CELLS; PROTEIN BINDING;

MUS;

EID: 34249724460     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.05.066     Document Type: Article

References (32)

1. Klee C.B., Ren H., and Wang X. Regulation of the calmodulin-stimulated protein phosphates, calcineurin. J. Biol. Chem. 273 (1998) 13367-13370
2. Rusnak F., and Mertz P. Calcineurin: form and function. Physiol. Rev. 80 (2000) 1483-1521
3. Kahl C.R., and Means A.R. Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. Endocr. Rev. 24 (2003) 719-736
4. Schulz R.A., and Yutzey K.E. Calcineuirn signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev. Biol. 266 (2004) 1-16
5. 2+, and calcineurin-signaling from the endoplasmic reticulum. Mol. Cells 17 (2004) 383-389
6. Crabtree G.R. Calcium, calcineurin, and the control of transcription. J. Biol. Chem. 276 (2001) 2313-2316
7. Hogan P.G., Chen L., Nardone J., and Rao A. Transcriptional regulation by calcium, calcineurin, and NFAT. Genes. Dev. 17 (2003) 2205-2232
8. Crabtree G.R., and Olson E.N. NFAT signaling: choreographing the social lives of cells. Cell 109 (2002) S67-S79
9. Crabtree G.R., and Clipstone N.A. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63 (1994) 1045-1083
10. Liu J., Farmer Jr. J.D., Lane W.S., Friedman J., Weissman I., and Schreiber S.L. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66 (1991) 807-815
11. Sun L., Youn H.D., Loh C., Stolow M., He W., and Liu J.O. Cabin1, a negative regulator for calcineurin signaling in T lymphocytes. Immunity 8 (1998) 703-711
12. Lai M.M., Burnett P.E., Wolosker H., Blackshaw S., and Snyder S.H. Cain, a novel physiologic protein inhibitor of calcineurin. J. Biol. Chem. 273 (1998) 18325-18331
13. 2+-induced release of the transcription factor MEF2. Science 286 (1999) 790-793
14. Youn H.D., and Liu J.O. Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. Immunity 13 (2000) 85-94
15. Lai M.M., Luo H.R., Burnett P.E., Hong J.J., and Synder S.H. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. J. Biol. Chem. 275 (2000) 34017-34020
16. Friday B.B., Horsley V., and Pavlath G.K. Calcineurin activity is required for the initiation of skeletal muscle differentiation. J. Cell. Biol. 149 (2000) 657-665
17. Taigen T., De Windt L.J., Lim H.W., and Molkentin J.D. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proc. Natl. Acad. Sci. USA 97 (2000) 1196-1201
18. De Windt L.J., Lim H.W., Bueno O.F., Liang Q., Delling U., Braz J.C., Glascock B.J., Kimball T.F., del Monte F., Hajjar R.J., and Molkentin J.D. Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. USA 98 (2001) 3322-3327
19. Delling U., Tureckova J., Lim H.W., De Windt L.J., Rotwein P., and Molkentin J.D. A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Mol. Cell. Biol. 20 (2000) 6600-6611
20. Molkentin J.D., Lu J.R., Antos C.L., Markham B., Richardson J., Robbins J., Grant S.R., and Olson E.N. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93 (1998) 215-228
21. Dong D., Duan Y., Guo J., Roach D.E., Swirp S.L., Wang L., Lees-Miller J.P., Sheldon R.S., Molkentin J.D., and Duff H.J. Overexpression of calcineurin in mouse causes sudden cardiac death associated with the decreased density of K+ channels. Cardiovasc. Res. 57 (2003) 320-332
22. Esau C., Boes M., Youn H.D., Tatterson L., Liu J.O., and Chen J. Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells. J. Exp. Med. 194 (2001) 1449-1459
23. Mondragon A., Griffith E.C., Sun L., Xiong F., Armstrong C., and Liu J.O. Overexpression and purification of human calcineurin α from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center. Biochemistry 36 (1997) 4934-4942
24. Isakov N., and Altman A. Protein kinase Cθ in T cell activation. Annu. Rev. Immunol. 20 (2002) 761-794
25. Aramburu J., Yaffe M.B., López-Rodríguez C., Cantley L.C., Hogan P.G., and Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporine A. Science 285 (1999) 2129-2133
26. Aramburu J., García-Cózar F., Raghavan A., Okamura H., Rao A., and Hogan P.G. Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT. Mol. Cell 1 (1998) 627-637
27. Liu J.O. Endogenous protein inhibitors of calcineurin. Biochem. Biophys. Res. Commun. 311 (2003) 1103-1109
28. Chan B., Greenan G., McKeon F., and Ellenberger T. Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc. Natl. Acad. Sci. USA 102 (2005) 13075-13080
29. Dell'Acqua M.L., Dodge K.L., Tavalin S.J., and Scott J.D. Mapping the protein phosphatase-2B anchoring site on AKAP79. J. Biol. Chem. 277 (2002) 48796-48802
30. Griffith J.P., Kim J.L., Kim E.E., Sintchak M.D., Tomson J.A., Fitzgibbon M.J., Fleming M.A., Caron P.R., Hsiao K., and Navia M.A. X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell 82 (1995) 507-522
31. Kissinger C.R., Parge H.E., Knighton D.R., Lewis C.T., Pelletier L.A., Tempczyk A., Kalish V.J., Tucker K.D., Showalter R.E., Moomaw E.W., Gastinel L.N., Habuka N., Chen X., Malonado F., Barker J.E., Bacquet R., and Villafranca J.E. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature 378 (1995) 641-644
32. Winder D.G., Mansuy I.M., Osman M., Moallem T.M., and Kandel E.R. Genetic and pharmacological evidence for a novel intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92 (1998) 25-37