Protective effect of ursodeoxycholic acid on liver mitochondrial function in rats with alloxan-induced diabetes: Link with oxidative stress

Life Sciences

Volumn 80, Issue 26, 2007, Pages 2397-2402

  Lukivskaya, Oxana ^a   Patsenker, Eleonora ^a,b   Buko, Vyacheslav U ^a  

^a INSTITUTE OF BIOCHEMISTRY   (Belarus)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Alloxan; Diabetes; Liver; Mitochondria; Oxidative phosphorylation; Oxidative stress; Ursodeoxycholic acid

Indexed keywords

ADENOSINE DIPHOSPHATE; ALLOXAN; CARBONYL DERIVATIVE; GLUTATHIONE; LUCIGENIN; LUMINOL; MALIC ACID; MITOCHONDRIAL ENZYME; PALMITOYLCARNITINE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUCCINATE DEHYDROGENASE; SUCCINIC ACID; URSODEOXYCHOLIC ACID;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; LIPID PEROXIDATION; LIVER MITOCHONDRION; LIVER PROTECTION; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RAT; RESPIRATION CONTROL;

ALLOXAN; ANIMALS; CHEMILUMINESCENT MEASUREMENTS; DIABETES MELLITUS, EXPERIMENTAL; LIVER; MALE; MALONDIALDEHYDE; MITOCHONDRIA; NADH DEHYDROGENASE; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RATS; RATS, WISTAR; SUCCINATE DEHYDROGENASE; URSODEOXYCHOLIC ACID;

RATTUS; RATTUS NORVEGICUS;

EID: 34249691888     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.02.042     Document Type: Article

References (60)

1. Aggarwal B.B., Quintahilha A.T., Cammack R., and Packer L. Damage to mitochondrial electron transport and energy coupling by visible light. Biochimica et Biophysica Acta 502 (1978) 367-382
2. Aruna R.V., Ramesh B., and Kartha V.N. Effect of betacarotene on protein glycosylation in alloxan induced diabetic rats. Indian Journal of Experimental Biology 37 (1999) 399-401
3. Azzaroli F., Mehal W., Soroka C.J., Wang L., Lee J., Crispe N., and Boyer J.L. Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. Hepatology 36 (2002) 49-54
4. Bakker S.J., Uzerman R.G., Teerlink T., Westerhoff H.V., Gans R.O., and Heine R.J. Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction and beta-cell failure?. Atherosclerosis 148 (2000) 17-21
5. Baynes J.W. Role of oxidative stress in diabetic complications. Diabetes 48 (1999) 1-9
6. Baynes J.W., and Thorpe S.R. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48 (1999) 1-9
7. Bellentani S., Chao Y.C., Feretti R., and Tiribelli C. Chronic administration of ursodeoxycholic and tauroursodeoxycholic acid changes microsomal membrane lipid content and fatty acid compositions in rats. Biochemical and Biophysical Research Communication 220 (1996) 479-483
8. Bindoli A. Lipid peroxidation and mitochondria. Free Radical Biology & Medicine 5 (1988) 247-261
9. Botla R., Spivey J.R., Aguilar H., Bronk S.F., and Gores G.J. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. Journal of Pharmacology and Experimental Therapeutics 272 (1995) 930-938
10. Buege J.K.A., and Aust S.D. Microsomal lipid peroxidation. Methods in Enzymology 52 (1978) 302-301
11. Buko V.U., Artsukevich A., Lukivskaya O., Zavodnik L., Ignatenko K., Sadovnichy V., Sushko L., and Tauschel H.-D. Antiradical and antioxidative properties of compounds having the steroid structure. Current Topics in Biophysics 22 Suppl 2 (1998) 33-39
12. Buko V.U., Lukivskaya O., Zavodnik L.B., Sadovnichy V.V., Petushok N.E., and Tauschel H.-D. Antioxidative effect of ursodeoxycholic acid in the liver of rats with oxidative stress caused by gamma-irradiation. Ukrainian Biochemical Journal 74 (2002) 88-93
13. 2+ and includes lipid peroxidation and membrane properties. Archives of Biochemistry and Biophysics 308 (1994) 158-163
14. Chen J.J., and Yu B.P. Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radical Biology & Medicine 17 (1994) 411-418
15. DeLange R.J., and Glazer A.N. Bile acids: antioxidants or enhancers of peroxidation depending on lipid concentration. Archives of Biochemistry and Biophysics 276 (1990) 19-25
16. Esposito L.A., Melov S., Panov A., Cotrell B.A., and Wallace D.C. Mitochondrial disease in mouse results in increased oxidative stress. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 4820-4825
17. Estabrook R.W. Mitochondrial respiratory control and the polarographic measurement of ADP:O ratio. Methods in Enzymology 10 (1967) 41-47
18. Fereira F.M., Palmeira C.M., Seica R., Moreno A.J., and Santos M.S. Diabetes and mitochondrial bioenergetics: alterations with age. Journal of Biochemical and Molecular Toxicology 17 (2003) 214-222
19. Geetha A., and Prameswari S. Effect of ursodeoxycholic acid on hydrogen peroxide induced lipid peroxidation in sheep liver mitochondria. Indian Journal of Physiology and Pharmacology 46 (2002) 343-348
20. Gerbitz K.-D., Gempel K., and Brdiczka D. Mitochondria and diabetes. Genetic, biochemical and clinical implications of the cellular energy circuit. Diabetes 45 (1996) 113-126
21. Giles A.R. Guideliness for the use of animals in biomedical research. Thrombosis and Haemostasis 58 (1987) 1078-1084
22. Güldutuna S., Zimmer G., Imhof M., Bhatti S., You T., and Leuschner U. Molecular aspects of membrane stabilization by ursodeoxycholate. Gastroenterology 104 (1993) 1736-1744
23. Ho E., Chen G., and Bray T.M. Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. FASEB Journal 13 (1999) 1845-1854
24. Huang Q., Shao L., Miao Z.C., Shi Q.D., and Liu S.S. Effect of insulin on oxygen free radicals and oxidative phosphorylation in liver mitochondria of diabetic rats. Acta Pharmacologica Sinica 22 (2001) 455-458
25. Jain S.K., McVie R., and Smith T. Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children. Diabetes Care 23 (2000) 1389-1394
26. Kaplowitz N., and Tsukamoto H. Oxidative stress and liver disease. Progress in Liver Diseases 14 (1996) 131-159
27. Kristal B.S., Matsuda M., and Yu B.P. Abnormalities in the mitochondrial permeability transition in diabetic rats. Biochemical and Biophysical Research Communication 222 (1996) 519-523
28. Kristal B.S., Koopmans S.J., Jackson C.T., Ikeno Y., Park B.J., and Yu B.P. Oxidant-mediated repression of mitochondrial transcription in diabetic rats. Free Radical Biology & Medicine 22 (1997) 813-822
29. Kristal B.S., Vigneau-Callahan K.E., Moskowitz A.J., and Matson W. Purine catabolism: links to mitochondrial respiration and antioxidant defenses?. Archives of Biochemistry and Biophysics 370 (1999) 22-33
30. Kucharska J., Braunova J., Ulicna O., Zlatos L., and Gvozdjakova A. Deficit of coenzyme Q in heart and liver mitochondria of rats with streptozotocin-induced diabetes. Physiological Research 49 (2000) 411-418
31. Leuschner U., Guldutuna S., Bhatti S., Elze A., Imhof M., You T., and Zimmer G. TUDCA and UDCA are incorporated into hepatocyte membranes: different sites, but similar effects. Italian Journal of Gastroenterology 27 (1995) 376-377
32. Ljubuncic P., Fuhrman B., Oiknine J., Aviram M., and Bomzon A. Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages. Gut 39 (1996) 475-478
33. Ljubuncic P., Tanne Z., and Bomzon A. Ursodeoxycholic acid suppressed effect of lipid peroxidation in diseased liver in experimental cholestatic liver disease. Digestive Diseases and Sciences 45 (2000) 1921-1928
34. Luft R. The development of mitochondrial medicine. Biochimica et Biophysica Acta 1271 (1995) 1-6
35. Luft R., and Landau B.R. Mitochondrial medicine. Journal of Internal Medicine 238 (1995) 405-421
36. Lukivskaya O., Maskevich A., and Buko V. Effect of ursodeoxycholic acid on prostaglandin metabolism and microsomal membranes in alcoholic fatty liver. Alcohol 25 (2001) 99-105
37. Lukivskaya O., Lis R., Egorov A., Naruta E., Tauschel H.-D., and Buko V.U. The protective effect of ursodeoxycholic acid in alloxan-induced diabetes. Cell Biochemistry and Function 22 (2004) 97-103
38. Mackerer C.R., Paquet R.J., Mehlamann M.A., and Tobin R.I. Oxidation and phosphorylation in liver mitochondria from alloxan and streptozotocin diabetic rats. Proceedings of the Society for Experimental Biology and Medicine 137 (1971) 992-995
39. Melov S., Coskun P., Patel M., Tuinstra R., Cottrell B., Jun A.S., Zastawny T.H., Dizdaroglu M., Goodman S.I., Huang T.T., Miziorko H., Epstein C.J., and Wallace D.C. Mitochondrial disease in superoxide dismutase 2 mutant mice. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 846-851
40. Memon R.A., Mohan C., and Bessman S.P. Impaired mitochondrial protein synthesis in streptozotocin diabetic rat hepatocytes. Biochemistry and Molecular Biology International 37 (1995) 627-634
41. Mitsuyoshi H., Nakashima T., Sumida Y., Yoh T., Nakajima Y., Ishikawa H., Inaba K., Sakamoto Y., Okanoue T., and Kashima K. Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants. Biochemical and Biophysical Research Communication 263 (1999) 537-542
42. Müller-Peddinhaus R., and Wurl M. The amplified chemiluminiscence test to characterize antirheumatic drugs as oxygen radical scavenger. Biochemical Pharmacology 36 (1987) 1125-1132
43. Narabayashi H., Takeshige K., and Minakami S. Alteration of inner membrane components and damage of electron-transfer activities of bovine heart submitochondrial particles induced by NADPH-dependent lipid peroxidation. The Biochemical Journal 202 (1982) 97-105
44. Neuman M.G., Cameron R.G., Shear N.H., Bellentani S., and Tiribelli C. Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line. Gastroenterology 109 (1995) 555-563
45. Oliva L., Beauge F., Choquart D., Montet A.-M., Guitaoui M., and Montet J.-C. Ursodeoxycholic acid alleviates alcoholic fatty liver damage in rats. Alcoholism: Clinical and Experimental Research 22 (1998) 1538-1543
46. Padma P., and Setty O.H. Effect of administration of galactosamine hydrochloride on rat liver mitochondria. Indian Journal of Biochemistry and Biophysics 34 (1997) 296-301
47. Poli G., Dianzani M.U., Cheeseman K.H., Slater T.S., Lang J., and Esterbauer H. Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspension. The Biochemical Journal 227 (1985) 629-638
48. Ramanathan K., Shila S., Kumaran S., and Panneerselvam C. Ascorbic acid and alpha-tocopherol as potent modulators on arsenic induced toxicity in mitochondria. Journal of Nutritional Biochemistry 14 (2003) 416-420
49. Rodrigues C.M., Fan G., Ma X., Kren B.T., and Steer C.J. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation. Journal of Clinical Investigation 101 (1998) 2790-2799
50. Rodrigues C.M., Ma X., Linehan-Stieers C., Fan G., Kren B.T., and Steer C.J. Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation. Cell Death and Differentiation 6 (1999) 842-854
51. Sailaja Devi M.M., Suresh Y., and Das. Preservation of the antioxidant status in chemically-induced diabetes mellitus by melatonin. Journal of Pineal Research 29 (2000) 108-115
52. Serviddio G., Pereda J., Pallardo F.V., Carretero J., Borras C., Cutrin J., Vendemiale G., Poli G., Vina J., and Sastre J. Ursodeoxycholic acid protects against secondary biliary cirrhosis in rats by preventing mitochondrial oxidative stress. Hepatology 39 (2004) 711-720
53. Singer T.P. Determination of the activity of succinate, NADH, choline, and alpha-glycerophosphate dehydrogenases. Methods in Biochemical Analysis 22 (1974) 123-175
54. Smith R.P., and Ellman G.L. A study of the dependence of the human erythrocyte glucose transport system on membrane sulfhydryl groups. Journal of Membrane Biology 12 (1973) 177-188
55. Soto C.P., Perez B.L., Favari L.P., and Reyes J.L. Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Comparative biochemistry and physiology. Pharmacology, Toxicology and Endocrinology 119 (1998) 125-129
56. Swiss Academy of Medical Sciences, Swiss Academy of Sciences. Ethical principles and guidelines for scientific experiments on animals. Alternatives to Laboratory Animals 25 (1997) 379-384
57. Tabouy L., Zamora A.J., Oliva L., Montet A.-M., Beauge F., and Montet J.-C. Ursodeoxycholate protects against ethanol-induced liver mitochondrial injury. Life Scienes 63 (1998) 2259-2270
58. Wallace D.C. Mitochondrial diseases in man and mouse. Science 283 (1999) 488-493
59. Wallace D.C., Shoffner J.M., Trounce I., Brown M.D., Ballinger S.W., Corral-Debrinski M., Horton T., Jun A.S., and Lott M.T. Mitochondrial DNA mutations in human degenerative diseases and aging. Biochimica et Biophysica Acta 1271 (1995) 141-151
60. Zammit V.A., Corstophine C.G., Kolodzej M.P., and Fraser F. Lipid molecular order in liver mitochondrial outer membranes, and sensitivity of carnitine palmitoyltransferase I to malonyl-CoA. Lipids 33 (1998) 371-376