Identification of a new antifungal target site through a dual biochemical and molecular-genetics approach

Current Genetics

Volumn 30, Issue 2, 1996, Pages 159-165

  Gustafson, Gary ^a   Davis, George ^a   Waldron, Clive ^b   Smith, Amy ^a   Henry, Matthew ^a  

^a DowElanco   (United States)

^b Discovery Research   (United States)

Author keywords

Aspergillus nidulans; Dihydroorotate dehydrogenase; Fungicide; Resistance gene

Indexed keywords

ANTIFUNGAL AGENT; DIHYDROOROTATE DEHYDROGENASE; FUNGAL PROTEIN; QUINOLINE DERIVATIVE;

AMINO ACID SEQUENCE; ARTICLE; ASPERGILLUS NIDULANS; BIOCHEMISTRY; CONTROLLED STUDY; COSMID; DRUG MECHANISM; ESCHERICHIA COLI; GENE ISOLATION; GENE MUTATION; GENE SEQUENCE; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; RESTRICTION FRAGMENT;

ANTIFUNGAL AGENTS; ASPERGILLUS NIDULANS; BASE SEQUENCE; CLONING, MOLECULAR; COSMIDS; DNA, FUNGAL; DRUG RESISTANCE, MICROBIAL; MOLECULAR SEQUENCE DATA; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTOPLASTS; QUINOLINES;

ASPERGILLUS; EMERICELLA NIDULANS; ESCHERICHIA COLI;

EID: 0029744679     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050115     Document Type: Article

References (33)

1. Brent KJ (1988) Resistance experiences in europe. In: Delp CJ (ed) Fungicide resistance in North America. APS Press, St. Paul, Minnesota, pp 19-21
2. Chen J-J, Jones ME (1976) The cellular location of dihydroorotate dehydrogenase: relation to de novo biosynthesis of proteins. Arch Biochem Biophys 176:82-90
3. Chen SF, Ruben RL, Dexter DL (1986) Mechanism of action of the novel anticancer agent 6-fluoro-2-(2′-fluro-1,1′-biphenyl-4-yl)-3-methyl-4- quinolinecarboxylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis. Cancer Res 46:5014-5019
4. Chen SF, Perrella FW, Behrens DL, Papp LM (1992) Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium. Cancer Res 52:3521-3527
5. Coghlan MJ, Krumkalns EV, Caley BA, Hall HR, Arnold WR (1991) Novel agents for the control of cereal and grape powdery mildew: synthesis and investigation of 4-phenoxy quinolines. In: Moberg K (ed) The synthesis and chemistry of agrichemicals II. American Chemical Society, Washington DC, pp 538-552
6. Cohen Y, Reuveni M (1983) Occurrence of metalaxyl-resistant isolates of Phytophthora infestans in potato fields in Israel. Phytopathology 73:925-927
7. Davidse LC (1981) Resistance to acylalanine fungicides in Phytophthora megasperma f. sp. medacaginis. Neth J Plant Pathol 87:11-24
8. Davidse LC (1988 a) Benzimidazole fungicides: mechanism of action and resistance. In: Delp CJ (ed) Fungicide resistance in North America. APS Press, St. Paul, Minnesota, pp 25-27
9. Davidse LC (1988 b) Phenylamide fungicides: mechanism of action and resistance. In: Delp CJ (ed) Fungicide resistance in North America. APS Press, St. Paul, Minnesota, pp 63-65
10. DeFrees SA, Sawick DP, Cunningham B, Heinstein PF, Morre DJ, Cassady JM (1988) Structure-activity relationships of pyrimidines as dihydroorotate dehydrogenase inhibitors. Biochem Pharmacol 37:3807-3816
11. Devereux J, Haberli P, Smithies O (1984) A comprehensive set of sequence analysis programs for the VAX. Nuclic Acids Res 12:387-395
12. Douglas MG, McCammon MT, Vassarotti A (1986) Targeting proteins into mitochondria. Microbiol Rev 50:166-178
13. Dovas C, Skylakakis G, Georgopoulos SG (1976) The adaptability of the benomyl-resistant population of Cercospora beticola in northern Greece. Phytopathology 66:1452-1456
14. Edlich W, Lyr H (1987) Mechanism of action of dicarboximide fungicides. In: Lyr H. (ed) Modern selective fungicides. Fisher Verlag, Jena, Germany, pp 107-118
15. Georgopoulos SG, Chrysayi M, White GA (1975) Carboxin resistance in the haploid, the heterozygous diploid, and the plant-parasitic dicaryotic phase of Ustilago maydis. Pestic Biochem Physiol 5:543-551
16. Gustafson GD, Waldron C, Davis GE (1991) Isolation, characterization and genetic analysis of Aspergillus nidulans mutants resistant to the antifungal compound LY214352. Curr Microbiol 23:39-44
17. Hejnes G von, Steppuhn J, Herrmann RG (1989) Domain structure of mitochondrial and chloroplast targeting peptides. Eur J Biochem 180:535-545
18. Hines V, Johnston M (1989) Analysis of the kinetic mechanism of the bovine liver mitochondrial dihydroorotate dehydrogenase. Biochemistry 28:1222-1226.
19. Karibian D (1978) Dihydroorotate dehydrogenase (Escherichia coli). Methods Enzymol 51:58-63
20. Keon JPR, White GA, Hargreaves JA (1991) Isolation, characerization and sequence of a gene conferring resistance to the systemic fungicide carboxin from the maize smut pathogen, Ustilago maydis. Curr Genet 19:475-481
21. Koller W, Scheinpflug H (1987) Fungal resistance to sterol biosynthesis inhibitors: a new challenge. Plant Dis 71:1066-1074
22. Krungkrai J, Cerami A, Henderson GB (1991) Purification and characterization of dihydroorotate dehydrogenase from the rodent malaria parasite Plasmodium berghei. Biochemistry 30:1934-1939
23. Lyr H (1987) Aromatic hydrocarbon Fungicides. In: Lyr H (ed) Modern selective fungicides. Fisher Verlag, Jena, Germany, pp 43-73
24. Orth AB, Rzhetskaya M, Pell E, Tien M (1995) A serine (threonine) protein kinase confers fungicide resistance in the phytopathogenic fungus Ustilago maydis. Appl Environ Microbiol 61:2341-2345
25. Parker R, Patterson B (1987) Architecture of fungal introns: implications for spliceosome assembly. In: Inouye M, Dudock BS (eds) Molecular biology of RNA: new perspectives. Academic Press, San Diego, pp 133-141
26. Pearson WR, Lipman DJ (1988) Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 85:2444-2448.
27. Pommer EH, Lorenz G (1987) Dicarboximide fungicides. In: Lyr H (ed) Modern selective Fungicides. Fisher Verlag, Jena, Germany pp 91-106
28. Sambrook J, Fritsch EF, Maniatus T (1989) Molecular cloning: A laboratory manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
29. Stannis VF, Jones AL (1984) Genetics of benomyl resistance in Venturia inaequalis from North and South America, Europe and New Zealand. Can J Plant Pathol 6:283-290
30. Vahlensieck HF, Pridzun L, Reichenbach H, Hinnen A (1994) Identification of the yeast ACC1 gene product (acetyl-CoA carboxylase) as the target of the polyketide fungicide soraphen A. Curr Genet 25:95-100
31. Waldron C, Roberts CF (1974) Cold-sensitive mutants in Aspergillus nidulans. I. Isolation and general characterisation. Mol Gen Genet 134:99-113
32. Yelton MM, Hamer JE, Timberlake WE (1984) Transformation of Aspergillus nidulans by using a trpC plasmid. Proc Natl Acad Sci USA 81:1470-1474
33. Yelton MM, Timberlake WE, van den Hondel CAMJJ (1985) A cosmid for selecting genes by complementation in Aspergillus nidulans: selection of the developmentally regulated yA locus. Proc Natl Acad Sci USA 82:834-838