Rotenone-induced neurotoxicity of THP-1 cells requires production of reactive oxygen species and activation of phosphatidylinositol 3-kinase

Brain Research

Volumn 1153, Issue 1, 2007, Pages 12-19

  Hu, Jing Hui ^a   Zhu, Xing Zu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Akt; Inflammation; Phosphatidylinositol 3 kinase; Reactive oxygen species; Rotenone; THP 1 cells

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; ROTENONE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MICROGLIA; NEUROBLASTOMA; NEUROTOXICITY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANALYSIS OF VARIANCE; CELL LINE; CULTURE MEDIA, CONDITIONED; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INSECTICIDES; MONOCYTES; NEUROBLASTOMA; REACTIVE OXYGEN SPECIES; ROTENONE; TETRAZOLIUM SALTS; THIAZOLES; UP-REGULATION;

EID: 34249676257     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.03.006     Document Type: Article

References (39)

1. Alam M., and Schmidt W.J. Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav. Brain Res. 136 (2002) 317-324
2. Asanuma M., Miyazaki I., and Ogawa N. Neuroprotective effects of nonsteroidal anti-inflammatory drugs on neurodegenerative diseases. Curr. Pharm. Des. 10 (2004) 695-700
3. Baran C.P., Tridandapani S., Helgason C.D., Humphries R.K., Krystal G., and Marsh C.B. The inositol 5′-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J. Biol. Chem. 278 (2003) 38628-38636
4. Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., and Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3 (2000) 1301-1306
5. Bhat N.R., and Zhang P. Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J. Neurochem. 72 (1999) 112-119
6. Bollimuntha S., Ebadi M., and Singh B.B. TRPC1 protects human SH-SY5Y cells against salsolinol-induced cytotoxicity by inhibiting apoptosis. Brain Res. 1099 (2006) 141-149
7. Carmichael J., DeGraff W.G., Gazdar A.F., Minna J.D., and Mitchell J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res. 47 (1987) 936-942
8. Combs C.K., Johnson D.E., Cannady S.B., Lehman T.M., and Landreth G.E. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J. Neurosci. 19 (1999) 928-939
9. Droge W. Free radicals in the physiological control of cell function. Physiol. Rev. 82 (2002) 47-95
10. Forman H.J., and Torres M. Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am. J. Respir. Crit. Care Med. 166 (2002) S4-S8
11. Gao H.M., Hong J.S., Zhang W., and Liu B. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci. 22 (2002) 782-790
12. Gao H.M., Jiang J., Wilson B., Zhang W., Hong J.S., and Liu B. Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease. J. Neurochem. 81 (2002) 1285-1297
13. Gwinn M.R., and Vallyathan V. Respiratory burst: role in signal transduction in alveolar macrophages. J. Toxicol. Environ. Health, Part B. Crit. Rev. 9 (2006) 27-39
14. Hinz B., and Brune K. Cyclooxygenase-2-10 years later. J. Pharmacol. Exp. Ther. 300 (2002) 367-375
15. Hirsch E.C., Faucheux B., Damier P., Mouatt-Prigent A., and Agid Y. Neuronal vulnerability in Parkinson's disease. J. Neural Transm. Suppl. 50 (1997) 79-88
16. Klegeris A., and McGeer P.L. Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. Neurobiol. Aging 23 (2002) 787-794
17. Klegeris A., Walker D.G., and McGeer P.L. Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs). Neuropharmacology 38 (1999) 1017-1025
18. Konishi H., Matsuzaki H., Tanaka M., Takemura Y., Kuroda S., Ono Y., and Kikkawa U. Activation of protein kinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett. 410 (1997) 493-498
19. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19 (1996) 312-318
20. Lawson L.J., Perry V.H., Dri P., and Gordon S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience 39 (1990) 151-170
21. Lee E.O., Kang J.L., and Chong Y.H. The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells. J. Biol. Chem. 280 (2005) 7845-7853
22. Leslie N.R., Bennett D., Lindsay Y.E., Stewart H., Gray A., and Downes C.P. Redox regulation of PI 3-kinase signalling via inactivation of PTEN. EMBO J. 22 (2003) 5501-5510
23. Ling Z., Gayle D.A., Ma S.Y., Lipton J.W., Tong C.W., Hong J.S., and Carvey P.M. In utero bacterial endotoxin exposure causes loss of tyrosine hydroxylase neurons in the postnatal rat midbrain. Mov. Disord. 17 (2002) 116-124
24. Martindale J.L., and Holbrook N.J. Cellular response to oxidative stress: signaling for suicide and survival. J. Cell Physiol. 192 (2002) 1-15
25. McDonald D.R., Brunden K.R., and Landreth G.E. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J. Neurosci. 17 (1997) 2284-2294
26. McGeer P.L., and McGeer E.G. Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism Relat. Disord. 10 Suppl. 1 (2004) S3-S7
27. McGeer P.L., Itagaki S., Boyes B.E., and McGeer E.G. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38 (1988) 1285-1291
28. Orr C.F., Rowe D.B., and Halliday G.M. An inflammatory review of Parkinson's disease. Prog. Neurobiol. 68 (2002) 325-340
29. Qin L., Liu Y., Wang T., Wei S.J., Block M.L., Wilson B., Liu B., and Hong J.S. NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia. J. Biol. Chem. 279 (2004) 1415-1421
30. 2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN. Arch. Biochem. Biophys. 386 (2001) 275-280
31. Saravanan K.S., Sindhu K.M., and Mohanakumar K.P. Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease. Brain Res. 1049 (2005) 147-155
32. Selvaraj S.K., Giri R.K., Perelman N., Johnson C., Malik P., and Kalra V.K. Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor. Blood 102 (2003) 1515-1524
33. Sherer T.B., Betarbet R., Kim J.H., and Greenamyre J.T. Selective microglial activation in the rat rotenone model of Parkinson's disease. Neurosci. Lett. 341 (2003) 87-90
34. St-Germain M.E., Gagnon V., Mathieu I., Parent S., and Asselin E. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells. Int. J. Oncol. 24 (2004) 1311-1324
35. Takadera T., Shiraishi Y., and Ohyashiki T. Prostaglandin E2 induced caspase-dependent apoptosis possibly through activation of EP2 receptors in cultured hippocampal neurons. Neurochem. Int. 45 (2004) 713-719
36. Vanhaesebroeck B., and Alessi D.R. The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J. 346 Pt. 3 (2000) 561-576
37. Wang R.G., and Zhu X.Z. Subtoxic concentration of manganese synergistically potentiates 1-methyl-4-phenylpyridinium-induced neurotoxicity in PC12 cells. Brain Res. 961 (2003) 131-138
38. 2+-induced cyclooxygenase-2 expression. Am. J. Physiol. Lung Cell Mol. Physiol. 289 (2005) L883-L889
39. Zhao F.L., Hu J.H., and Zhu X.Z. Monocyte-mediated rotenone neurotoxicity towards human neuroblastoma SH-SY5Y: role of mitogen-activated protein kinases. Biol. Pharm. Bull. 29 (2006) 1372-1377