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Volumn 14, Issue 20, 2000, Pages 1943-1948
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High-throughput cytochrome P450 inhibition screening via cassette probe-dosing strategy. IV. Validation of a direct injection on-line guard cartridge extraction/tandem mass spectrometry method for simultaneous CYP3A4, 2D6 and 2E1 inhibition assessment
a
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Author keywords
[No Author keywords available]
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Indexed keywords
DRUG PRODUCTS;
EXTRACTION;
MASS SPECTROMETRY;
PROBES;
PROJECTILES;
THROUGHPUT;
96-WELL MICROTITER PLATE;
CYTOCHROME P450-3A4;
CYTOCHROMES P450;
DEXTROMETHORPHAN;
DOSING STRATEGY;
HIGH-THROUGHPUT;
MIDAZOLAM;
TANDEM MASS SPECTROMETRY;
TANDEM-MASS SPECTROMETRY;
THROUGHPUT EVALUATIONS;
DIRECT INJECTION;
ALPHA HYDROXYMIDAZOLAM;
CHLORZOXAZONE;
CYTOCHROME P 450 CYP2D6;
CYTOCHROME P 450 CYP2E1;
CYTOCHROME P450;
CYTOCHROME P450 2D6;
CYTOCHROME P450 2E1;
CYTOCHROME P450 3A4;
DEBRISOQUINE 4 HYDROXYLASE;
DEXTROMETHORPHAN;
DEXTRORPHAN;
DIMETHYLNITROSAMINE DEMETHYLASE;
ENZYME INHIBITOR;
FORMIC ACID;
ISOENZYME;
MIDAZOLAM;
NIFEDIPINE OXIDASE;
OXYGENASE;
ACCURACY;
ARTICLE;
CALIBRATION;
COST MINIMIZATION ANALYSIS;
DRUG SCREENING;
ENZYME INHIBITION;
EXTRACTION;
HUMAN;
HUMAN CELL;
IC 50;
IN VITRO STUDY;
LIVER MICROSOME;
MASS SPECTROMETRY;
ONLINE COMPUTER;
QUALITY CONTROL;
QUANTITATIVE ASSAY;
REPRODUCIBILITY;
TANDEM MASS SPECTROMETRY;
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EID: 0033775984
PISSN: 09514198
EISSN: None
Source Type: Journal
DOI: 10.1002/1097-0231(20001030)14:20<1943::AID-RCM116>3.0.CO;2-F Document Type: Article |
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Times cited : (25)
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References (10)
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