E-cadherin repression contributes to c-Myc-induced epithelial cell transformation

Oncogene

Volumn 26, Issue 24, 2007, Pages 3582-3586

  Cowling, V H ^a   Cole, M D ^a  

^a NORRIS COTTON CANCER CENTER   (United States)

Author keywords

c Myc; E cadherin; EMT; Epithelial cell; Transformation

Indexed keywords

MYC PROTEIN; UVOMORULIN;

ARTICLE; BREAST EPITHELIUM; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; EPITHELIUM CELL; EPITHELIUM TUMOR; GENE REPRESSION; HUMAN; HUMAN CELL; MESENCHYME CELL; ONCOGENE C MYC; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

BREAST NEOPLASMS; CADHERINS; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MAMMARY GLANDS, HUMAN; PROTO-ONCOGENE PROTEINS C-MYC;

EID: 34249305203     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210132     Document Type: Article

References (18)

1. Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J et al. (2000). The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2: 84-89.
2. Beavon IR. (2000). The E-cadherin-catenin complex in tumour metastasis: structure, function and regulation. Eur J Cancer 36: 1607-1620.
3. Bittner M, Meltzer P, Chen Y, Jiang Y, Seftor E, Hendrix M et al. (2000). Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 406: 536-540.
4. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG et al. (2000). The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2: 76-83.
5. Christofori G, Semb H. (1999). The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 24: 73-76.
6. Clark EA, Golub TR, Lander ES, Hynes RO. (2000). Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406: 532-535.
7. Cowling VH, Cole MD. (2006). Mechanism of transcriptional activation by the Myc oncoproteins. Semin Cancer Biol 16: 242-252.
8. Dang CV, O'Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F. (2006). The c-Myc target gene network. Semin Cancer Biol 16: 253-264.
9. DiRenzo J, Signoretti S, Nakamura N, Rivera-Gonzalez R, Sellers W, Loda M et al. (2002). Growth factor requirements and basal phenotype of an immortalized mammary epithelial cell line. Cancer Res 62: 89-98.
10. Gottardi CJ, Wong E, Gumbiner BM. (2001). E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol 153: 1049-1060.
11. Graff JR, Herman JG, Lapidus RG, Chopra H, Xu R, Jarrard DF et al. (1995). E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas. Cancer Res 55: 5195-5199.
12. Niveditha SR, Bajaj P. (2003). Vimentin expression in breast carcinomas. Indian J Pathol Microbiol 46: 579-584.
13. Pelengaris S, Khan M, Evan G. (2002). c-MYC: more than just a matter of life and death. Nat Rev Cancer 2: 764-776.
14. Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. (1998). A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392: 190-193.
15. Shiio Y, Donohoe S, Yi EC, Goodlett DR, Aebersold R, Eisenman RN. (2002). Quantitative proteomic analysis of Myc oncoprotein function. EMBO J 21: 5088-5096.
16. Stockinger A, Eger A, Wolf J, Beug H, Foisner R. (2001). E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J Cell Biol 154: 1185-1196.
17. Thiery JP. (2002). Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
18. Thiery JP. (2003). Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15: 740-746.