Strategies for developing protein tyrosine phosphatase inhibitors

Methods

Volumn 42, Issue 3, 2007, Pages 250-260

  Tautz, Lutz ^a   Mustelin, Tomas ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Docking; Homology modeling; HTS; Inhibitor development; Lead optimization; Protein tyrosine phosphatases; PTPs; SAR; Small molecule PTP inhibitors; Virtual screening

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE INHIBITOR;

ARTICLE; COMPUTER MODEL; COMPUTER PROGRAM; ENZYME ANALYSIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; SCREENING;

BACTERIAL OUTER MEMBRANE PROTEINS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; MODELS, MOLECULAR; NITROPHENOLS; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDE LIBRARY; PROTEIN-TYROSINE-PHOSPHATASE; ROSANILINE DYES;

EID: 34249052551     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2007.02.014     Document Type: Article

References (30)

1. Hunter T., and Sefton B.M. Proc. Natl. Acad. Sci. USA 77 (1980) 1311-1315
2. Alonso A., Sasin J., Bottini N., Friedberg I., Friedberg I., Osterman A., Godzik A., Hunter T., Dixon J., and Mustelin T. Cell 117 (2004) 699-711
3. Tautz L., Pellecchia M., and Mustelin T. Expert Opin. Ther. Targets 10 (2006) 157-177
4. You-Ten K.E., Muise E.S., Itie A., Michaliszyn E., Wagner J., Jothy S., Lapp W.S., and Tremblay M.L. J. Exp. Med. 186 (1997) 683-693
5. Zhang E.E., Chapeau E., Hagihara K., and Feng G.S. Proc. Natl. Acad. Sci. USA 101 (2004) 16064-16068
6. Charbonneau H., Tonks N.K., Kumar S., Diltz C.D., Harrylock M., Cool D.E., Krebs E.G., Fischer E.H., and Walsh K.A. Proc. Natl. Acad. Sci. USA 86 (1989) 5252-5256
7. Zhang J.H., Chung T.D., and Oldenburg K.R. J. Biomol. Screen. 4 (1999) 67-73
8. H. Akaike, Second International Symposium on Information Theory, Akademia Kiado, Budapest (1973), New York, 1998, pp. 267-281.
9. McGovern S.L., Helfand B.T., Feng B., and Shoichet B.K. J. Med. Chem. 46 (2003) 4265-4272
10. Bova M.P., Mattson M.N., Vasile S., Tam D., Holsinger L., Bremer M., Hui T., McMahon G., Rice A., and Fukuto J.M. Arch. Biochem. Biophys. 429 (2004) 30-41
11. Tautz L., Bruckner S., Sareth S., Alonso A., Bogetz J., Bottini N., Pellecchia M., and Mustelin T. J. Biol. Chem. 280 (2005) 9400-9408
12. Doman T.N., McGovern S.L., Witherbee B.J., Kasten T.P., Kurumbail R., Stallings W.C., Connolly D.T., and Shoichet B.K. J. Med. Chem. 45 (2002) 2213-2221
13. Makino S., and Kuntz I.D. J. Comput. Chem. 18 (1997) 1812-1825
14. Rarey M., Kramer B., Lengauer T., and Klebe G. J. Mol. Biol. 261 (1996) 470-489
15. Jones G., Willett R., Glen R., Leach A.R., and Taylor R. J. Mol. Biol. 267 (1997) 727-748
16. Morris G.M., Goodsell D.S., Halliday R., Huey R., Hart W.E., Belew R.K., and Olson A.J. J. Comput. Chem. 19 (1998) 1639-1662
17. Friesner R.A., Banks J.L., Murphy R.B., Halgren T.A., Klicic J.J., Mainz D.T., Repasky M.P., Knoll E.H., Shelley M., Perry J.K., Shaw D.E., Francis P., and Shenkin P.S. J. Med. Chem. 47 (2004) 1739-1749
18. McMartin C., and Bohacek R.S. J. Comput. Aided Mol. Des. 11 (1997) 333-344
19. Abagyan R., Totrov M., and Kuznetsov R. J. Comput. Chem. 15 (1994) 488-506
20. Chen H., Lyne P.D., Giordanetto F., Lovell T., and Li J. J. Chem. Inf. Model. 46 (2006) 401-415
21. Schwede T., Kopp J., Guex N., and Peitsch M.C. Nucl. Acids Res. 31 (2003) 3381-3385
22. Marti-Renom M.A., Stuart A., Fiser A., Sánchez R., Melo F., and Sali A. Annu. Rev. Biophys. Biomol. Struct. 29 (2000) 291-325
23. Bottini N., Musumeci L., Alonso A., Rahmouni S., Nika K., Rostamkhani M., MacMurray J., Meloni G.F., Lucarelli P., Pellecchia M., Eisenbarth G.S., Comings D., and Mustelin T. Nat. Genet. 36 (2004) 337-338
24. Vang T., Congia M., Macis M.D., Musumeci L., Orru V., Zavattari P., Nika K., Tautz L., Tasken K., Cucca F., Mustelin T., and Bottini N. Nat. Genet. 37 (2005) 1317-1319
25. Barford D., Flint A.J., and Tonks N.K. Science 263 (1994) 1397-1404
26. Nicholls A., Sharp K.A., and Honig B. Proteins: Stuct. Funct. Genet. 11 (1991) 281-296
27. Heiden W., Moeckel G., and Brickmann J. J. Comput. Aided Mol. Des. 7 (1993) 503-514
28. Persson C., Nordfelth R., Holmstrom A., Hakansson S., Rosqvist R., and Wolf-Watz H. Mol. Microbiol. 18 (1995) 135-150
29. Cheng L.W., and Schneewind O. J. Bacteriol. 182 (2000) 3183-3190
30. Alonso A., Bottini N., Bruckner S., Rahmouni S., Williams S., Schoenberger S.P., and Mustelin T. J. Biol. Chem. 279 (2004) 4922-4928