Yersinia enterocolitica TyeA, an intracellular regulator of the type III machinery, is required for specific targeting of YopE, YopH, YopM, and YopN into the cytosol of eukaryotic cells

Journal of Bacteriology

Volumn 182, Issue 11, 2000, Pages 3183-3190

  Cheng, Luisa W ^a   Schneewind, Olaf ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL FRACTIONATION; CYTOSOL; EUKARYOTIC CELL; GENE TARGETING; GENE TRANSLOCATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; YERSINIA ENTEROCOLITICA;

BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; CALCIUM SIGNALING; CARRIER PROTEINS; CELL COMPARTMENTATION; CELL FRACTIONATION; CYTOSOL; EUKARYOTIC CELLS; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MUTATION; PROTEIN-TYROSINE-PHOSPHATASE; YERSINIA ENTEROCOLITICA;

BACTERIA (MICROORGANISMS); EUKARYOTA; NEGIBACTERIA; YERSINIA; YERSINIA ENTEROCOLITICA;

EID: 0034085052     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.182.11.3183-3190.2000     Document Type: Article

References (42)

1. Anderson, D. M., and O. Schneewind. 1997. A mRNA signal for the type III secretion of Yop proteins by Yersinia enterocolitica. Science 278:1140-1143.
2. Anderson, D. M., and O. Schneewind. 1999. Type III machines of Gram-negative pathogens: injecting virulence factors into host cells and more. Curr. Opin. Microbiol. 2:18-24.
3. Anderson, D. M., and O. Schneewind. 1999. Yersinia enterocolitica type III secretion: an mRNA signal that couples translation and secretion of YopQ. Mol. Microbiol. 31:1139-1148.
4. Bergman, T., S. Håkansson, A. Forsberg, L. Norlander, A. Macellaro, A. Bäckman, I. Bölin, and H. Wolf-Watz. 1991. Analysis of the V antigen lcrGVH-yopBD operon of Yersinia pseudotuberculosis: evidence for a regulatory role of LcrH and LcrV. J. Bacteriol. 173:1607-1616.
5. Boland, A., M.-P. Sory, M. Iriarte, C. Kerbourch, P. Wattiau, and G. R. Cornelis. 1996. Status of YopM and YopN in the Yersinia yop virulon: YopM of Y. enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus. EMBO J. 15:5191-5201.
6. Butler, T. 1995. Yersinia species, p. 1748-1756. In G. L. Mandell, R. G. Douglas, and J. E. Bennett (ed.), Infectious diseases, 5th ed. Churchill Livingstone, New York, N.Y.
7. Cheng, L. W., D. M. Anderson, and O. Schneewind. 1997. Two independent type III secretion mechanisms for YopE in Yersinia enterocolitica. Mol. Microbiol. 24:757-765.
8. Cheng, L. W., and O. Schneewind. 1999. Yersinia enterocolitica type III secretion: on the role of SycE in targeting YopE into HeLa cells. J. Biol. Chem. 274:22102-22108.
9. Cornelis, G. R. 1998. The Yersinia deadly kiss. J. Bacteriol. 180:5495-5504.
10. Cornelis, G. R., A. Boland, A. P. Boyd, C. Geuijen, M. Iriarte, C. Neyt, M.-P. Sory, and I. Stainier. 1998. The virulence plasmid of Yersinia, an antihost genome. Microbiol. Mol. Biol. Rev. 62:1315-1352.
11. Cornelis, G. R., and H. Wolf-Watz. 1997. The Yersinia Yop virulon: a bacterial system for subverting eukaryotic cells. Mol. Microbiol. 23:861-867.
12. Day, J. B., and G. V. Plano. 1998. A complex composed of SycN and YscB functions as a specific chaperone for YopN in Yersinia pestis. Mol. Microbiol. 30:777-789.
13. Fields, K. A., M. L. Nilles, C. Cowan, and S. C. Straley. 1999. Virulence role of V antigen of Yersinia pestis at the bacterial surface. Infect. Immun. 67: 5395-5408.
14. Forsberg, A., A.-M. Viitanen, M. Skunik, and H. Wolf-Watz. 1991. The surface-located YopN protein is involved in calcium signal transduction in Yersinia pseudotuberculosis. Mol. Microbiol. 5:977-986.
15. Goguen, J. D., J. Yother, and S. C. Straley. 1984. Genetic analysis of the low calcium response in Yersinia pestis Mu d1(Ap lac) insertion mutants. J. Bacteriol. 160:842-848.
16. Hakånsson, S., E. Gaylov, R. Rosqvist, and H. Wolf-Watz. 1996. The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane. Mol. Microbiol. 20:593-603.
17. Holmström, A., J. Petterson, R. Rosqvist, S. Hakånsson, F. Tafazoli, M. Fällman, K.-E. Magnusson, H. Wolf-Watz, and A. Forsberg. 1997. YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane. Mol. Microbiol. 24:73-91.
18. Iriarte, M., and G. R. Cornelis. 1999. Identification of SycN, YscX, and YscY, three new elements of the Yersinia yop virulon. J. Bacteriol. 181:675-680.
19. Iriarte, M., and G. R. Cornelis. 1998. YopT, a new Yersinia effector protein, affects the cytoskeleton of host cells. Mol. Microbiol. 29:915-929.
20. Iriarte, M., M.-P. Sory, A. Boland, A. P. Boyd, S. D. Mills, I. Lambermont, and G. R. Cornelis. 1998. TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors. EMBO J. 17:1907-1918.
21. Jackson, M. W., J. B. Day, and G. V. Plano. 1998. YscB of Yersinia pestis functions as a specific chaperone for YopN. J. Bacteriol. 180:4912-4921.
22. Koster, M., W. Bitter, H. de Cock, A. Allaoui, G. R. Cornelis, and J. Tommassen. 1997. The outer membrane component, YscC, of the Yop secretion machinery of Yersinia enterocolitica forms a ring-shaped multimeric complex. Mol. Microbiol. 26:789-797.
23. Lee, V. T., D. M. Anderson, and O. Schneewind. 1998. Targeting of Yersinia Yop proteins into the cytosol of HeLa cells: one-step translocation of YopE across bacterial and eukaryotic membranes is dependent on SycE chaperone. Mol. Microbiol. 28:593-601.
24. Lee, V. T., and O. Schneewind. Type III secretion machines and the pathogenesis of enteric infections caused by Yersinia and Salmonella spp. 1999. Immunol. Rev. 168:241-255.
25. Lee, V. T., and O. Schneewind. 1999. Type III machines of pathogenic yersiniae secrete virulence factors into the extracellular milieu. Mol. Microbiol. 31:1619-1629.
26. Michiels, T., and G. R. Cornelis. 1991. Secretion of hybrid proteins by the Yersinia Yop export system. J. Bacteriol. 173:1677-1685.
27. Michiels, T., P. Wattiau, R. Brasseur, J.-M. Ruysschaert, and G. Cornelis. 1990. Secretion of Yop proteins by yersiniae. Infect. Immun. 58:2840-2849.
28. Nouwen, N., N. Ranson, H. Saibil, B. Wolpensinger, A. Engel, A. Ghazi, and A. P. Pugsley. 1999. Secretin PulD: association with pilot PulS, structure, and ion-conducting channel formation. Proc. Natl. Acad. Sci. USA 96:8173-8177.
29. Persson, C., R. Nordfelth, A. Holmström, S. Hakånsson, R. Rosqvist, and H. Wolf-Watz. 1995. Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell. Mol. Microbiol. 18:135-150.
30. Petterson, J., A. Holmström, J. Hill, E. Frithz-Lindsten, A. von Euler-Matell, E. Carlsson, R. Titball, A. Forsberg, and H. Wolf-Watz. 1999. The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation. Mol. Microbiol. 32:961-976.
31. Rosqvist, R., A. Forsberg, and H. Wolf-Watz. 1991. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infect. Immun. 59:4562-4569.
32. Rosqvist, R., K.-E. Magnusson, and H. Wolf-Watz. 1994. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J. 13:964-972.
33. Russel, M. 1994. Phage assembly: a paradigm for bacterial virulence factor export? Science 265:612-614.
34. Schesser, K., E. Frithz-Lindsten, and H. Wolf-Watz. 1996. Delineation and mutational analysis of the Yersinia pseudotuberculosis YopE domains which mediate translocation across bacterial and eukaryotic cellular membranes. J. Bacteriol. 178:7227-7233.
35. Skrzypek, E., and S. C. Straley. 1993. LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis. J. Bacteriol. 175:3520-3528.
36. Sory, M.-P., A. Boland, I. Lambermont, and G. R. Cornelis. 1995. Identification of the YopE and YopH domains required for secretion and internalization into the cytosol of macrophages, using the cyaA gene fusion approach. Proc. Natl. Acad. Sci. USA 92:11998-12002.
37. Stainier, I., M. Iriarte, and G. R. Cornelis. 1997. YscM1 and YscM2, two Yersinia enterocolitica proteins causing downregulation of yop transcription. Mol. Microbiol. 26:833-843.
38. 2+ response. Mol. Microbiol. 8:1005-1010.
39. Wattiau, P., and G. R. Cornelis. 1993. SycE, a chaperone-like protein of Yersinia enterocolitica involved in the secretion of YopE. Mol. Microbiol. 8:123-131.
40. Williams, A. W., and S. C. Straley. 1998. YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops. J. Bacteriol. 180:350-358.
41. Yother, J., T. W. Chamness, and J. D. Goguen. 1986. Temperature controlled plasmid regulon associated with low calcium response in Yersinia pestis. J. Bacteriol. 165:443-447.
42. 2+-blind mutants of Yersinia pestis. J. Bacteriol. 164:704-711.