Vitamin B12b increases the cytotoxicity of short-time exposure to ascorbic acid, inducing oxidative burst and iron-dependent DNA damage

European Journal of Pharmacology

Volumn 566, Issue 1-3, 2007, Pages 206-214

  Solovieva, Marina E ^a,b   Soloviev, Valery V ^a   Akatov, Vladimir S ^a,b  

^a RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

^b PUSHCHINO STATE UNIVERSITY   (Russian Federation)

Author keywords

Ascorbic acid; Cytotoxicity; DNA single strand break; Hydrogen peroxide; Oxidative stress; Tumor cell; Vitamin B12b

Indexed keywords

ACETYLCYSTEINE; ASCORBIC ACID; CATALASE; DEFEROXAMINE; DITHIOTHREITOL; GLUTATHIONE; HYDROGEN PEROXIDE; HYDROXOCOBALAMIN; IRON CHELATING AGENT; PHENANTHROLINE; PYRUVIC ACID; SINGLE STRANDED DNA; THIOL; 2,9 DIMETHYL 1,10 PHENANTHROLINE; ANTIOXIDANT; IRON; PHENANTHROLINE DERIVATIVE; VITAMIN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DNA STRAND BREAKAGE; HEP 2 CELL; HUMAN; HUMAN CELL; LARYNX CARCINOMA; NONHUMAN; OXIDATION KINETICS; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY BURST; CELL SURVIVAL; DRUG EFFECT; METABOLISM; SINGLE STRANDED DNA BREAK; TUMOR CELL LINE;

ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CELL LINE, TUMOR; CELL SURVIVAL; DEFEROXAMINE; DNA BREAKS, SINGLE-STRANDED; HUMANS; HYDROGEN PEROXIDE; HYDROXOCOBALAMIN; IRON; IRON CHELATING AGENTS; OXIDATIVE STRESS; PHENANTHROLINES; RESPIRATORY BURST; VITAMINS;

EID: 34249034286     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.03.035     Document Type: Article

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