CYP121, CYP51 and associated redox systems in Mycobacterium tuberculosis: Towards deconvoluting enzymology of P450 systems in a human pathogen

Biochemical Society Transactions

Volumn 34, Issue 6, 2006, Pages 1178-1182

  McLean, K J ^a   Dunford, A J ^a   Sabri, M ^a   Neeli, R ^a   Girvan, H M ^a   Balding, P R ^a   Leys, D ^b   Seward, H E ^c   Marshall, K R ^c   Munro, A W ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Azole binding; CYP121; Cytochrome P450; Haem; Mycobacterium tuberculosis; Redox system

Indexed keywords

ANTIBIOTIC AGENT; CLOTRIMAZOLE; CYTOCHROME; CYTOCHROME P450 121; FERREDOXIN; FLAVOPROTEIN; FLUCONAZOLE; IRON SULFUR PROTEIN; PYRROLE; STEROL 14ALPHA DEMETHYLASE; TRIAZOLE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CYTOCHROME P 450 CYP121; CYTOCHROME P 450 CYP51, MYCOBACTERIUM TUBERCULOSIS; CYTOCHROME P-450 CYP121; CYTOCHROME P-450 CYP51, MYCOBACTERIUM TUBERCULOSIS; CYTOCHROME P450; PYRROLE DERIVATIVE;

ANTIBIOTIC RESISTANCE; BACTERIAL GROWTH; CONFERENCE PAPER; DRUG SYNTHESIS; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYMOLOGY; HUMAN; MUTATIONAL ANALYSIS; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; PATHOGENICITY; PROTEIN BINDING; PROTEIN CONFORMATION; REVIEW;

ACTINOBACTERIA; CORYNEBACTERINEAE; ESCHERICHIA COLI; FUNGI; MYCOBACTERIUM TUBERCULOSIS;

AZOLES; BACTERIAL PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 34248671409     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0341178     Document Type: Conference Paper

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