Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia

Molecular Oncology

Volumn 1, Issue 1, 2007, Pages 97-119

  Celis, Julio E ^a,b   Moreira, José M A ^a,b   Gromova, Irina ^a,b   Cabezón, Teresa ^a,b   Gromov, Pavel ^a,b   Shen, Tao ^a,b   Timmermans, Vera ^a,c   Rank, Fritz ^a,c  

^a Institute of Cancer Biolog   (Denmark)

^b DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^c Rigshospitalet   (Denmark)

Author keywords

15 PGDH; Apocrine carcinomas; Breast precancerous lesions; CK15 positive myoepithelial and luminal cells; Proteomics; Sclerosing adenosis

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; CALGRANULIN; MELANOMA ANTIGEN 4; PROTEIN P53; PSORIASIN; TUMOR MARKER;

ADULT; AGED; ANTIBODY SPECIFICITY; APOCRINE CARCINOMA; ARTICLE; BREAST BIOPSY; BREAST CANCER; BREAST DYSPLASIA; CANCER CELL; CELL HYPERPLASIA; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; MASS SPECTROMETRY; MITOSIS; MYOEPITHELIUM CELL; PRECANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ADULT; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; FIBROCYSTIC BREAST DISEASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPERPLASIA; METAPLASIA; MIDDLE AGED; NEOPLASM PROTEINS; PRECANCEROUS CONDITIONS; TUMOR MARKERS, BIOLOGICAL;

EID: 34248665259     PISSN: 15747891     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molonc.2007.02.005     Document Type: Article

References (127)

1. Adriance M.C., Inman J.L., Petersen O.W., and Bissell M.J. Myoepithelial cells: good fences make good neighbors. Breast Cancer Res. 7 (2005) 190-197
2. Agnantis N.J., Mahera H., Maounis N., and Spandidos D.A. Immunohistochemical study of ras and myc oncoproteins in apocrine breast lesions with and without papillomatosis. Eur. J. Gynaecol. Oncol. 13 (1992) 309-315
3. Aitken A. 14-3-3 and its possible role in co-ordinating multiple signalling pathways. Trends Cell Biol. 6 (1996) 341-347
4. Allred D.C., and Mohsin S.K. Biological features of human premalignant breast disease. In: Harris R. (Ed). Diseases of the Breast (2000), Lippincott Williams & Wilkins, Philadelphia
5. Allred D.C., Mohsin S.K., and Fuqua S.A. Histological and biological evolution of human premalignant breast disease. Endocri. Relat. Cancer 8 (2001) 47-61
6. Angeli A., Bradlow H.L., Bodian C.A., Chasalow F.I., Dogliotti L., and Haagensen Jr. D.E. Criteria for classifying breast cyst fluids. Ann. N.Y. Acad. Sci. 586 (1990) 49-52
7. Arai K., Teratani T., Kuruto-Niwa R., Yamada T., and Nozawa R. S100A9 expression in invasive ductal carcinoma of the breast: S100A9 expression in adenocarcinoma is closely associated with poor tumour differentiation. Eur. J. Cancer 40 (2004) 1179-1187
8. Bankfalvi A., Ludwig A., De-Hesselle B., Buerger H., Buchwalow I.B., and Boecker W. Different proliferative activity of the glandular and myoepithelial lineages in benign proliferative and early malignant breast diseases. Mod. Pathol. 17 (2004) 1051-1061
9. Barbareschi M., Pecciarini L., Cangi M.G., Macri E., Rizzo A., Viale G., and Doglioni C. p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Am. J. Surg. Pathol. 25 (2001) 1054-1060
10. Bartkova J., Rezaei N., Liontos M., Karakaidos P., Kletsas D., Issaeva N., Vassiliou E., Kolettas L.V., Niforou K., Zoumpourlis V.C., Takaoka M., Nakagawa H., Tort F., Fugger K., Johansson F., Sehested M., Andersen C.L., Dyrskjot L., Orntoft T., Lukas J., Kittas C., Helleday T., Halazonetis T.D., Bartek J., and Gorgoulis V.G. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444 (2006) 633-637
11. Berman J.J., Albores-Saavedra J., Bostwick D., Delellis R., Eble J., Hamilton S.R., Hruban R.H., Mutter G.L., Page D., Rohan T., Travis W., and Henson D.E. Precancer: a conceptual working definition - results of a Consensus Conference. Cancer Detect. Prev. 30 (2006) 387-394
12. Bocker W., Moll R., Poremba C., Holland R., Van Diest P.J., Dervan P., Burger H., Wai D., Ina Diallo R., Brandt B., Herbst H., Schmidt A., Lerch M.M., and Buchwallow I.B. Common adult stem cells in the human breast give rise to glandular and myoepithelial cell lineages: a new cell biological concept. Lab. Invest. 82 (2002) 737-746
13. Bolli M., Kocher T., Adamina M., Guller U., Dalquen P., Haas P., Mirlacher M., Gambazzi F., Harder F., Heberer M., Sauter G., and Spagnoli G.C. Tissue microarray evaluation of melanoma antigen E (MAGE) tumor-associated antigen expression: potential indications for specific immunotherapy and prognostic relevance in squamous cell lung carcinoma. Ann. Surg. 236 (2002) 785-793
14. Bruzzi P., Dogliotti L., Naldoni C., Bucchi L., Costantini M., Cicognani A., Torta M., Buzzi G.F., and Angeli A. Cohort study of association of risk of breast cancer with cyst type in women with gross cystic disease of the breast. BMJ 314 (1997) 925-928
15. Carlsson H., Petersson S., and Enerback C. Cluster analysis of S100 gene expression and genes correlating to psoriasin (S100A7) expression at different stages of breast cancer development. Int. J. Oncol. 27 (2005) 1473-1481
16. Carter D.J., and Rosen P.P. Atypical apocrine metaplasia in sclerosing lesions of the breast: a study of 51 patients. Mod. Pathol. 4 (1991) 1-5
17. Celis J.E., Ostergaard M., Basse B., Celis A., Lauridsen J.B., Ratz G.P., Andersen I., Hein B., Wolf H., Orntoft T.F., and Rasmussen H.H. Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas. Cancer Res. 56 (1996) 4782-4790
18. Celis J.E., Celis P., Ostergaard M., Basse B., Lauridsen J.B., Ratz G., Rasmussen H.H., Orntoft T.F., Hein B., Wolf H., and Celis A. Proteomics and immunohistochemistry define some of the steps involved in the squamous differentiation of the bladder transitional epithelium: a novel strategy for identifying metaplastic lesions. Cancer Res. 59 (1999) 3003-3009
19. Celis A., Rasmussen H.H., Celis P., Basse B., Lauridsen J.B., Ratz G., Hein B., Ostergaard M., Wolf H., Orntoft T., and Celis J.E. Short-term culturing of low-grade superficial bladder transitional cell carcinomas leads to changes in the expression levels of several proteins involved in key cellular activities. Electrophoresis 20 (1999) 355-361
20. Celis J.E., Gromov P., Gromova I., Moreira J.M., Cabezon T., Ambartsumian N., Grigorian M., Lukanidin E., Thor Straten P., Guldberg P., Bartkova J., Bartek J., Lukas J., Lukas C., Lykkesfeldt A., Jaattela M., Roepstorff P., Bolund L., Orntoft T., Brunner N., Overgaard J., Sandelin K., Blichert-Toft M., Mouridsen H., and Rank F.E. Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. Mol. Cell. Proteomics 2 (2003) 369-377
21. Celis J.E., Gromov P., Cabezon T., Moreira J.M., Ambartsumian N., Sandelin K., Rank F., and Gromova I. Proteomic characterization of the interstitial fluid perfusing the breast tumor microenvironment: a novel resource for biomarker and therapeutic target discovery. Mol. Cell. Proteomics 3 (2004) 327-344
22. Celis J.E., Moreira J.M., Gromova I., Cabezon T., Ralfkiaer U., Guldberg P., Straten P.T., Mouridsen H., Friis E., Holm D., Rank F., and Gromov P. Towards discovery-driven translational research in breast cancer. FEBS J. 272 (2005) 2-15
23. Celis J.E., Moreira J.M., Cabezon T., Gromov P., Friis E., Rank F., and Gromova I. Identification of extracellular and intracellular signaling components of the mammary adipose tissue and its interstitial fluid in high risk breast cancer patients: toward dissecting the molecular circuitry of epithelial-adipocyte stromal cell interactions. Mol. Cell. Proteomics 4 (2005) 492-522
24. Celis J.E., Gromov P., Moreira J.M., Cabezon T., Friis E., Vejborg I.M., Proess G., Rank F., and Gromova I. Apocrine cysts of the breast: biomarkers, origin, enlargement, and relation with cancer phenotype. Mol. Cell Proteomics 5 (2006) 462-483
25. Celis J.E., Gromova I., Gromov P., Moreira J.M., Cabezon T., Friis E., and Rank F. Molecular pathology of breast apocrine carcinomas: a protein expression signature specific for benign apocrine metaplasia. FEBS Lett. 580 (2006) 2935-2944
26. Celis J.E., Trentemølle S., and Gromov P. Gel-based proteomics: high-resolution two-dimensional gel electrophoresis of proteins. isoelectric focusing (IEF) and nonequilibrium pH gradient electrophoresis (NEPHGE). In: Celis J.E., Carter N., Hunter T., Simons K., Small J.V., and Shotton D. (Eds). A Cell Biology. Laboratory Handbook. third ed. (2006), Academic Press, San Diego 165-174 4 V
27. Celis J.E., Moreira J.M.A., and Gromov P. Determination of antibody specificity by Western blotting. In: Celis J.E., Carter N., Hunter T., Simons K., Small J.V., and Shotton D. (Eds). A Cell Biology. Laboratory Handbook. third ed. (2006), Academic Press, San Diego 527-532 4 V
28. Chan K., and Morris G.J. Chemoprevention of breast cancer for women at high risk. Semin. Oncol. 33 (2006) 642-646
29. Clahsen P.C., van de Velde C.J., Duval C., Pallud C., Mandard A.M., Delobelle-Deroide A., van den Broek L., Sahmoud T.M., and van de Vijver M.J. p53 protein accumulation and response to adjuvant chemotherapy in premenopausal women with node-negative early breast cancer. J. Clin. Oncol. 16 (1998) 470-479
30. Collado M., Gil J., Efeyan A., Guerra C., Schuhmache A.J., Barradas M., Benguria A., Zaballos A., Flores J.M., Barbacid M., Beach D., and Serrano M. Tumour biology: senescence in premalignant tumours. Nature 436 (2005) 642
31. Collins I., and Workman P. New approaches to molecular cancer therapeutics. Nat. Chem. Biol. 2 (2006) 689-700
32. Costa A., Bonanni B., Manetti L., Guerrieri Gonzaga A., Torrisi R., and Decensi A. Prevention of breast cancer: focus on chemoprevention. Recent Results. Cancer Res. 152 (1998) 11-21
33. Courtois-Cox S., Genther Williams S.M., Reczek E.E., Johnson B.W., McGillicuddy L.T., Johannessen C.M., Hollstein P.E., MacCollin M., and Cichowski K. A negative feedback signaling network underlies oncogene-induced senescence. Cancer Cell 10 (2006) 459-472
34. Cyrlak D., and Carpenter P.M. Breast imaging case of the day. Fat necrosis of the breast. Radiographics 19 (1999) S80-S83
35. Dabbs D.J., Carter G., Fudge M., Peng Y., Swalsky P., and Finkelstein S. Molecular alterations in columnar cell lesions of the breast. Mod. Pathol. 19 (2006) 344-349
36. Dawson P.J., Wolman S.R., Tait L., Heppner G.H., and Miller F.R. MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am. J. Pathol. 148 (1996) 313-319
37. Di Micco R., Fumagalli M., Cicalese A., Piccinin S., Gasparini P., Luise C., Schurra C., Garre M., Nuciforo P.G., Bensimon A., Maestro R., Pelicci P.G., and d'Adda di Fagagna F. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444 (2006) 638-642
38. Durham J.R., and Fechner R.E. The histologic spectrum of apocrine lesions of the breast. Am. J. Clin. Pathol. 113 5 Suppl. 1 (2000) S3-S18
39. Elston C.W., and Ellis I.O. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19 (1991) 403-410
40. Endoh Y., Tamura G., Kato N., and Motoyama T. Apocrine adenosis of the breast: clonal evidence of neoplasia. Histopathology 38 (2001) 221-224
41. Enerback C., Porter D.A., Seth P., Sgroi D., Gaudet J., Weremowicz S., Morton C.C., Schnitt S., Pitts R.L., Stampl J., Barnhart K., and Polyak K. Psoriasin expression in mammary epithelial cells in vitro and in vivo. Cancer Res. 62 (2002) 43-47
42. Fridriksdottir A.J., Villadsen R., Gudjonsson T., and Petersen O.W. Maintenance of cell type diversification in the human breast. J. Mammary Gland Biol. Neoplasia 10 (2005) 61-74
43. Gatalica Z. Immunohistochemical analysis of apocrine breast lesions. Consistent over-expression of androgen receptor accompanied by the loss of estrogen and progesterone receptors in apocrine metaplasia and apocrine carcinoma in situ. Pathol. Res. Pract. 193 (1997) 753-758
44. Gebhardt C., Nemeth J., Angel P., and Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem. Pharmacol. 72 (2006) 1622-1631
45. Gordon L.A., Mulligan K.T., Maxwell-Jones H., Adams M., Walker R.A., and Jones J.L. Breast cell invasive potential relates to the myoepithelial phenotype. Int. J. Cancer 106 (2003) 8-16
46. Gromova I., and Celis J.E. Protein detection in gels by silver staining: a procedure compatible with mass-spectrometry. In: Celis J.E., Carter N., Hunter T., Shotton D., Simons K., and Small J.V. (Eds). Cell Biology. A Laboratory Handbook vol. 4 (2006), Academic Press, San Diego 219-223
47. Gudjonsson T., Ronnov-Jessen L., Villadsen R., Rank F., Bissell M.J., and Petersen O.W. Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J. Cell. Sci. 115 (2002) 39-50
48. Gudjonsson T., Ronnov-Jessen L., Villadsen R., Bissell M.J., and Petersen O.W. To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia. Methods 30 (2003) 247-255
49. Gudjonsson T., Adriance M.C., Sternlicht M.D., Petersen O.W., and Bissell M.J. Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J. Mammary Gland Biol. Neoplasia 10 (2005) 261-272
50. Guinebretière J.M., Menet E., Tardivon A., Cherel P., and Vanel D. Normal and pathological breast, the histological basis. Eur. J. Radiol. 54 (2005) 6-14
51. Haagensen C.D. Diseases of the Breast. third ed. (1986), W.B. Saunders, Philadelphia 250-266
52. Haagensen Jr. D.E. Is cystic disease related to breast cancer?. Am. J. Surg. Pathol. 15 (1991) 687-694
53. Herceg, Z., Hainaut, P. Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis. Mol. Oncol., doi:10.1016/j.molonc.2007.01.004.
54. Jih D.M., Lyle S., Elenitsas R., Elder D.E., and Cotsarelis G. Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells. J. Cutan. Pathol. 26 (1999) 113-118
55. Jones C., Damiani S., Wells D., Chaggar R., Lakhani S.R., and Eusebi V. Molecular cytogenetic comparison of apocrine hyperplasia and apocrine carcinoma of the breast. Am. J. Pathol. 158 (2001) 207-214
56. Kenny, P.A., Lee, G.Y., Myers, C.A., Neve, R.M., Semeiks, J.R., Spellman, P.T., Lorenz, K., Lee, E.H., Barcellos-Hof, M.H., Petersen, O.W., Gray, J.W. and Bissel, M.J. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol. Oncol., doi:10.1016/j.molonc.2007.02.004.
57. Kerlikowske K., Grady D., Rubin S.M., Sandrock C., and Ernster V.L. Efficacy of screening mammography. A meta-analysis. JAMA 273 (1995) 149-154
58. Krishnamurthy S., and Sneige N. Molecular and biologic markers of premalignant lesions of human breast. Adv. Anat. Pathol. 9 (2002) 185-197
59. Krop I., Marz A., Carlsson H., Li X., Bloushtain-Qimron N., Hu M., Gelman R., Sabel M.S., Schnitt S., Ramaswamy S., Kleer C.G., Enerback C., and Polyak K. A putative role for psoriasin in breast tumor progression. Cancer Res. 65 (2005) 11326-11334
60. Lacroix M. Significance, detection and markers of disseminated breast cancer cells. Endocr. Relat. Cancer 13 (2006) 1033-1067
61. Lai L.C., Kadory S., Siraj A.K., and Lennard T.W. Oncostatin M, interleukin 2, interleukin 6 and interleukin 8 in breast cyst fluid. Int. J. Cancer 59 (1994) 369-372
62. Lai L.C., Siraj A.K., Erbas H., and Lennard T.W. Transforming growth factor alpha, beta 1 and beta 2 in breast cyst fluid. Anticancer Res. 14 (1994) 2805-2809
63. Landry C., Brasseur F., Spagnoli G.C., Marbaix E., Boon T., Coulie P., and Godelaine D. Monoclonal antibody 57B stains tumor tissues that express gene MAGE-A4. Int. J. Cancer 86 (2000) 835-841
64. Leffers H., Madsen P., Rasmussen H.H., Honore B., Andersen A.H., Walbum E., Vandekerckhove J., and Celis J.E. Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. J. Mol. Biol. 231 (1993) 982-998
65. Lerwill M.F. Current practical applications of diagnostic immunohistochemistry in breast pathology. Am. J. Surg. Pathol. 28 (2004) 1076-1091
66. Liefers G.J., and Tollenaar R.A. Cancer genetics and their application to individualised medicine. Eur. J. Cancer 38 (2002) 872-879
67. Madsen P., Rasmussen H.H., Leffers H., Honore B., Dejgaard K., Olsen E., Kiil J., Walbum E., Andersen A.H., Basse B., et al. Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. J. Invest. Dermatol. 97 (1991) 701-712
68. Mazoujian G., Pinkus G.S., Davis S., and Haagensen Jr. D.E. Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features. Am. J. Pathol. 110 (1983) 105-112
69. McCann A., Johnston P.A., Dervan P.A., Gullick W.J., and Carney D.N. c-erB-2 oncoprotein expression in malignant and nonmalignant breast tissue. Ir. J. Med. Sci. 158 (1989) 137-140
70. Mills A.A., Zheng B., Wang X.J., Vogel H., Roop D.R., and Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 398 (1999) 708-713
71. Moll R. Cytokeratins as markers of differentiation in the diagnosis of epithelial tumors. Subcell. Biochem. 31 (1998) 205-262
72. Moreira J.M., Ohlsson G., Rank F.E., and Celis J.E. Down-regulation of the tumor suppressor protein 14-3-3sigma is a sporadic event in cancer of the breast. Mol. Cell. Proteomics 4 (2005) 555-569
73. Moriya T., Sakamoto K., Sasano H., Kawanaka M., Sonoo H., Manabe T., and Ito J. Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases. Mod. Pathol. 13 (2000) 13-18
74. Moriya T., Kasajima A., Ishida K., Kariya Y., Akahira J., Endoh M., Watanabe M., and Sasano H. New trends of immunohistochemistry for making differential diagnosis of breast lesions. Med. Mol. Morphol. 39 (2006) 8-13
75. Nagaraja G.M., Othman M., Fox B.P., Alsaber R., Pellegrino C.M., Zeng Y., Khanna R., Tamburini P., Swaroop A., and Kandpal R.P. Gene expression signatures and biomarkers of noninvasive and invasive breast cancer cells: comprehensive profiles by representational difference analysis, microarrays and proteomics. Oncogene 25 (2006) 2328-2338
76. Ness J.C., Sedghinasab M., Moe R.E., and Tapper D. Identification of multiple proliferative growth factors in breast cyst fluid. Am. J. Surg. 166 (1993) 237-243
77. Nielsen T.O., Hsu F.D., Jensen K., Cheang M., Karaca G., Hu Z., Hernandez-Boussard T., Livasy C., Cowan D., Dressler L., Akslen L.A., Ragaz J., Gown A.M., Gilks C.B., van de Rijn M., and Perou C.M. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin. Cancer Res. 10 16 (Aug 15 2004) 5367-5374
78. O'Farrell P.H. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 250 (1975) 4007-4021
79. O'Malley F.P., and Bane A.L. The spectrum of apocrine lesions of the breast. Adv. Anat. Pathol. 11 (2004) 1-9
80. Ohyama M., Vogel J.C., and Amagai M. Gene ontology analysis of human hair follicle bulge molecular signature. J. Dermatol. Sci. 45 (2007) 147-150
81. Olsen O., and Gotzsche P.C. Cochrane review on screening for breast cancer with mammography. Lancet 358 (2001) 1340-1342
82. Ostergaard M., Wolf H., Orntoft T.F., and Celis J.E. Psoriasin (S100A7): a putative urinary marker for the follow-up of patients with bladder squamous cell carcinomas. Electrophoresis 20 (1999) 349-354
83. Page D.L., and Simpson J.F. What is apocrine adenosis, anyway?. Histopathology 39 (2001) 433-434
84. Papamichalis G., Francia K., Karachaliou F.E., Anastasiades O.T., and Spandidos D.A. Expression of the c-myc oncoprotein in human metaplastic epithelial cells of fibrocystic disease. Anticancer Res. 8 (1988) 1217-1222
85. Pathology Reporting Of Breast Cancer, 2005. NHS Breast Screening Programme Publication no. 58.
86. Pechoux C., Gudjonsson T., Ronnov-Jessen L., Bissell M.J., and Petersen O.W. Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Dev. Biol. 206 (1999) 88-99
87. Perou C.M., Sorlie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Rees C.A., Pollack J.R., Ross D.T., Johnsen H., Akslen L.A., Fluge O., Pergamenschikov A., Williams C., Zhu S.X., Lonning P.E., Borresen-Dale A.L., Brown P.O., and Botstein D. Molecular portraits of human breast tumours. Nature 406 (2000) 747-752
88. Pinder S.E., and Reis-Filho J.S. Non operative breast pathology: columnar cell lesions. J. Clin. Pathol (2006) (Epub ahead of print)
89. Pinder S.E., Wencyk P., Sibbering D.M., Bell J.A., Elston C.W., Nicholson R., Robertson J.F., Blamey R.W., and Ellis I.O. Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival. Br. J. Cancer 71 (1995) 146-149
90. Polyak K., and Hu M. Do myoepithelial cells hold the key for breast tumor progression?. J. Mammary Gland Biol. Neoplasia 10 (2005) 231-247
91. Quidville V., Segond N., Lausson S., Frenkian M., Cohen R., and Jullienne A. 15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line. Prostaglandins Other Lipid Mediat. 81 (2006) 14-30
92. Rabinovitz I., and Mercurio A.M. The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J. Cell Biol. 139 (1997) 1873-1884
93. Reed M.J., Coldham N.G., Patel S.R., Ghilchik M.W., and James V.H. Interleukin-1 and interleukin-6 in breast cyst fluid: their role in regulating aromatase activity in breast cancer cells. J. Endocrinol. 132 (1992) R5-R8
94. Rimoldi D., Salvi S., Schultz-Thater E., Spagnoli G.C., and Cerottini J.C. Anti-MAGE-3 antibody 57B and anti-MAGE-1 antibody 6C1 can be used to study different proteins of the MAGE-A family. Int. J. Cancer 86 (2000) 749-751
95. Rohan T.E., Li S.Q., Hartwick R., and Kandel R.A. p53 Alterations and protein accumulation in benign breast tissue and breast cancer risk: a cohort study. Cancer Epidemiol. Biomarkers Prev. 15 (2006) 1316-1323
96. Rosen P.P. Rosen's Breast Pathology Book (1997), Lippincott-Raven pp. 123-142
97. Schnitt S.J., and Vincent-Salomon A. Columnar cell lesions of the breast. Adv. Anat. Pathol. 10 (2003) 113-124
98. Seidman J.D., Ashton M., and Lefkowitz M. Atypical apocrine adenosis of the breast: a clinicopathologic study of 37 patients with 8.7-year follow-up. Cancer 77 (1996) 2529-2537
99. Selim A.G., Ryan A., El-Ayat G.A., and Wells C.A. Loss of heterozygosity and allelic imbalance in apocrine adenosis of the breast. Cancer Detect. Prev. 25 (2001) 262-267
100. Selim A.G., El-Ayat G., Naase M., and Wells C.A. C-myc oncoprotein expression and gene amplification in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. Breast 11 (2002) 466-472
101. Selim A.G., El-Ayat G., and Wells C.A. Expression of c-erbB2, p53, Bcl-2, Bax, c-myc and Ki-67 in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. Virchows Arch. 441 (2002) 449-455
102. Selim A.G., Ryan A., El-Ayat G., and Wells C.A. Loss of heterozygosity and allelic imbalance in apocrine metaplasia of the breast: microdissection microsatellite analysis. J. Pathol. 196 (2002) 287-291
103. Shevchenko A., Wilm M., Vorm O., and Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68 (1996) 850-858
104. Simpson J.F., and Page D.L. Apocrine adenosis - mimic of mammary carcinoma. Surg. Pathol. 3 (1990) 289-299
105. Simpson P.T., Gale T., Reis-Filho J.S., Jones C., Parry S., Steele D., Cossu A., Budroni M., Palmieri G., and Lakhani S.R. Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue. J. Pathol. 202 (2004) 274-285
106. Simpson P.T., Gale T., Reis-Filho J.S., Jones C., Parry S., Sloane J.P., Hanby A., Pinder S.E., Lee A.H., Humphreys S., Ellis I.O., and Lakhani S.R. Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis. Am. J. Surg. Pathol. 29 (2005) 734-746
107. Skliris G.P., Lewis A., Emberley E., Peng B., Weebadda W.K., Kemp A., Davie J.R., Shiu R.P., Watson P.H., and Murphy L.C. Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer. Breast Cancer Res. Treat. (2006) (Epub ahead of print)
108. Sorlie T., Perou C.M., Tibshirani R., Aas T., Geisler S., Johnsen H., Hastie T., Eisen M.B., van de Rijn M., Jeffrey S.S., Thorsen T., Quist H., Matese J.C., Brown P.O., Botstein D., Eystein Lonning P., and Borresen-Dale A.L. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 10869-10874
109. Stingl J., Eaves C.J., Kuusk U., and Emerman J.T. Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast. Differentiation 63 (1998) 201-213
110. Stingl J., Eaves C.J., Zandieh I., and Emerman J.T. Characterization of bipotent mammary epithelial progenitor cells in normal adult human breast tissue. Breast Cancer Res. Treat. 67 (2001) 93-109
111. Stoll B.A. Premalignant breast lesions: role for biological markers in predicting progression to cancer. Eur. J. Cancer 35 (1999) 693-697
112. Tapper D., Gajdusek C., Moe R., and Ness J. Identification of a unique biological tumor marker in human breast cyst fluid and breast cancer tissue. Am. J. Surg. 159 (1990) 473-478
113. Tavassoli F.A., and Norris H.J. Intraductal apocrine carcinoma: a clinicopathologic study of 37 cases. Mod. Pathol. 7 (1994) 813-818
114. Tavassoli F.A., Purcell C.A., and Man Y.G. Down regulation of bcl2, ER, PR associated with AR expression is triggered by apocrine differentiation of mammary epithelium. Mod. Pathol. 9 (1996) 25A
115. Triggle D.J. Drug discovery and delivery in the 21st century. Med. Princ. Pract. 16 (2007) 1-14
116. Tse G.M., Tan P.H., Chaiwun B., Putti T.C., Lui P.C., Tsang A.K., Wong F.C., and Lo A.W. p63 is useful in the diagnosis of mammary metaplastic carcinomas. Pathology 38 (2006) 16-20
117. van Diest P.J., van der Wall E., and Baak J.P. Prognostic value of proliferation in invasive breast cancer: a review. J. Clin. Pathol. 57 (2004) 675-681
118. Viacava P., Naccarato A.G., and Bevilacqua G. Spectrum of GCDFP-15 expression in human fetal and adult normal tissues. Virchows Arch. 432 (1998) 255-260
119. Villadsen, R., Fridriksdottir, A.J., Rønnov-Jessen, L., Gudjonsson, T., Rank F., LaBarge M.A., Bissel, M.J., Petersen O.W., 2007. Evidence for a stem cell hierarchy in the adult human breast. J. Cell Sci. 177, 87-101.
120. Washington C., Dalbegue F., Abreo F., Taubenberger J.K., and Lichy J.H. Loss of heterozygosity in fibrocystic change of the breast: genetic relationship between benign proliferative lesions and associated carcinomas. Am. J. Pathol. 157 (2000) 323-329
121. Weidner N., Moore II D.H., and Vartanian R. Correlation of Ki-67 antigen expression with mitotic figure index and tumor grade in breast carcinomas using the novel "paraffin"-reactive MIB1 antibody. Hum. Pathol. 25 (1994) 337-342
122. Wellings S.R., and Alpers C.E. Apocrine cystic metaplasia: subgross pathology and prevalence in cancer-associated versus random autopsy breasts. Hum. Pathol. 18 (1987) 381-386
123. Wellings S.R., Jensen H.M., and Marcum R.G. An atlas of subgross pathology of the human breast with special reference to possible precancerous lesions. J. Natl. Cancer Inst. 55 (1975) 231-273
124. Wells C.A., McGregor I.L., Makunura C.N., Yeomans P., and Davies J.D. Apocrine adenosis: a precursor of aggressive breast cancer?. J. Clin. Pathol. 48 (1995) 737-742
125. Wolf I., O'Kelly J., Rubinek T., Tong M., Nguyen A., Lin B.T., Tai H.H., Karlan B.Y., and Koeffler H.P. 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer. Cancer Res. 66 (2006) 7818-7823
126. Zagorianakou P., Zagorianakou N., Stefanou D., Makrydimas G., and Agnantis N.J. The enigmatic nature of apocrine breast lesions. Virchows Arch. 448 (2006) 525-531
127. Zhang R.R., Man Y.G., Vang R., Saenger J.S., Barner R., Wheeler D.T., Liang C.Y., Vinh T.N., and Bratthauer G.L. A subset of morphologically distinct mammary myoepithelial cells lacks corresponding immunophenotypic markers. Breast Cancer Res. 5 (2003) 151-156