메뉴 건너뛰기




Volumn 79, Issue , 2007, Pages 1-11

The Destructive Alliance: Interactions Of Leukocytes, Cerebral Endothelial Cells, and the Immune Cascade in Pathogenesis of Multiple Sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; ENDOTHELIUM CELL; HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; LEUKOCYTE; MULTIPLE SCLEROSIS; PATHOLOGY; REVIEW;

EID: 34248663505     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(07)79001-3     Document Type: Review
Times cited : (13)

References (53)
  • 1
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott N.J., Ronnback L., and Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7 (2006) 41-53
    • (2006) Nat. Rev. Neurosci. , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 2
    • 1642281535 scopus 로고    scopus 로고
    • Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion
    • Barnett M.H., and Prineas J.W. Relapsing and remitting multiple sclerosis: Pathology of the newly forming lesion. Ann. Neurol. 55 (2004) 458-468
    • (2004) Ann. Neurol. , vol.55 , pp. 458-468
    • Barnett, M.H.1    Prineas, J.W.2
  • 3
    • 0027529932 scopus 로고
    • Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma
    • Baron J.L., Madri J.A., Ruddle N.H., Hashim G., and Janeway Jr. C.A. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177 (1993) 57-68
    • (1993) J. Exp. Med. , vol.177 , pp. 57-68
    • Baron, J.L.1    Madri, J.A.2    Ruddle, N.H.3    Hashim, G.4    Janeway Jr., C.A.5
  • 4
    • 0027207679 scopus 로고
    • MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1
    • Briskin M.J., McEvoy L.M., and Butcher E.C. MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. Nature 363 6428 (1993) 461-464
    • (1993) Nature , vol.363 , Issue.6428 , pp. 461-464
    • Briskin, M.J.1    McEvoy, L.M.2    Butcher, E.C.3
  • 5
    • 0036196241 scopus 로고    scopus 로고
    • The pathology of primary progressive multiple sclerosis
    • Bruck W., Lucchinetti C., and Lassmann H. The pathology of primary progressive multiple sclerosis. Mult. Scler. 8 (2002) 93-97
    • (2002) Mult. Scler. , vol.8 , pp. 93-97
    • Bruck, W.1    Lucchinetti, C.2    Lassmann, H.3
  • 6
    • 0025127157 scopus 로고
    • Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis
    • Cross A.H., Cannella B., Brosnan C.F., and Raine C.S. Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. Lab. Invest. 63 (1990) 162-170
    • (1990) Lab. Invest. , vol.63 , pp. 162-170
    • Cross, A.H.1    Cannella, B.2    Brosnan, C.F.3    Raine, C.S.4
  • 8
    • 0032535368 scopus 로고    scopus 로고
    • The development of experimental autoimmune encephalomyelitis in the mouse requires α4-integrin but not α4β7-integrin
    • Engelhardt B., Laschinger M., Schulz M., Samulowitz U., Vestweber D., and Hoch G. The development of experimental autoimmune encephalomyelitis in the mouse requires α4-integrin but not α4β7-integrin. J. Clin. Invest. 102 (1998) 2096-2105
    • (1998) J. Clin. Invest. , vol.102 , pp. 2096-2105
    • Engelhardt, B.1    Laschinger, M.2    Schulz, M.3    Samulowitz, U.4    Vestweber, D.5    Hoch, G.6
  • 9
    • 0035153262 scopus 로고    scopus 로고
    • Involvement of the choroid plexus in central nervous system inflammation
    • Engelhardt B., Wolburg-Buchholz K., and Wolburg H. Involvement of the choroid plexus in central nervous system inflammation. Microsc. Res. Tech. 52 (2001) 112-129
    • (2001) Microsc. Res. Tech. , vol.52 , pp. 112-129
    • Engelhardt, B.1    Wolburg-Buchholz, K.2    Wolburg, H.3
  • 10
    • 23244449103 scopus 로고    scopus 로고
    • P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice
    • Engelhardt B., Kempe B., Merfeld-Clauss S., Laschinger M., Furie B., Wild M.K., and Vestweber D. P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 mice. J. Immunol. 175 (2005) 1267-1275
    • (2005) J. Immunol. , vol.175 , pp. 1267-1275
    • Engelhardt, B.1    Kempe, B.2    Merfeld-Clauss, S.3    Laschinger, M.4    Furie, B.5    Wild, M.K.6    Vestweber, D.7
  • 12
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis-the plaque and its pathogenesis
    • Frohman E.M., Racke M.K., and Raine C.S. Multiple sclerosis-the plaque and its pathogenesis. N. Engl. J. Med. 354 (2006) 942-955
    • (2006) N. Engl. J. Med. , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 15
    • 0028202447 scopus 로고
    • The blood-retinal barrier in experimental autoimmune uveoretinitis. Leukocyte interactions and functional damage
    • Greenwood J., Howes R., and Lightman S. The blood-retinal barrier in experimental autoimmune uveoretinitis. Leukocyte interactions and functional damage. Lab. Invest. 70 (1994) 39-52
    • (1994) Lab. Invest. , vol.70 , pp. 39-52
    • Greenwood, J.1    Howes, R.2    Lightman, S.3
  • 16
    • 0028791506 scopus 로고
    • Lymphocyte adhesion and transendothelial migration in the central nervous system: The role of LFA-1, ICAM-1, VLA-4 and VCAM-1
    • Greenwood J., Wang Y., and Calder V.L. Lymphocyte adhesion and transendothelial migration in the central nervous system: The role of LFA-1, ICAM-1, VLA-4 and VCAM-1. Immunology 86 (1995) 408-415
    • (1995) Immunology , vol.86 , pp. 408-415
    • Greenwood, J.1    Wang, Y.2    Calder, V.L.3
  • 17
    • 0043136667 scopus 로고    scopus 로고
    • Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration
    • Greenwood J., Amos C.L., Walters C.E., Courand P.O., Lyck R., Engelhardt B., and Adamson P. Intracellular domain of brain endothelial intercellular adhesion molecule-1 is essential for T lymphocyte-mediated signaling and migration. J. Immunol. 171 (2003) 2099-2108
    • (2003) J. Immunol. , vol.171 , pp. 2099-2108
    • Greenwood, J.1    Amos, C.L.2    Walters, C.E.3    Courand, P.O.4    Lyck, R.5    Engelhardt, B.6    Adamson, P.7
  • 18
    • 30444445129 scopus 로고    scopus 로고
    • How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes
    • Hatterer E., Davoust N., Didier-Bazes M., Vuaillat C., Malcus C., Belin M.F., and Nataf S. How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 107 (2006) 806-812
    • (2006) Blood , vol.107 , pp. 806-812
    • Hatterer, E.1    Davoust, N.2    Didier-Bazes, M.3    Vuaillat, C.4    Malcus, C.5    Belin, M.F.6    Nataf, S.7
  • 19
    • 20144381022 scopus 로고    scopus 로고
    • Elevated endothelial microparticle-monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-beta 1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes
    • Jimenez J., Jy W., Mauro L.M., Horstman L.L., Ahn E.R., Ahn Y.S., and Minagar A. Elevated endothelial microparticle-monocyte complexes induced by multiple sclerosis plasma and the inhibitory effects of interferon-beta 1b on release of endothelial microparticles, formation and transendothelial migration of monocyte-endothelial microparticle complexes. Mult. Scler. 11 (2005) 310-315
    • (2005) Mult. Scler. , vol.11 , pp. 310-315
    • Jimenez, J.1    Jy, W.2    Mauro, L.M.3    Horstman, L.L.4    Ahn, E.R.5    Ahn, Y.S.6    Minagar, A.7
  • 20
    • 13344276666 scopus 로고    scopus 로고
    • Endothelial microparticles (EMP) bind and activate monocytes: Elevated EMP-monocyte conjugates in multiple sclerosis
    • Jy W., Minagar A., Jimenez J.J., Sheremata W.A., Mauro L.M., Horstman L.L., Bidot C., and Ahn Y.S. Endothelial microparticles (EMP) bind and activate monocytes: Elevated EMP-monocyte conjugates in multiple sclerosis. Front. Biosci. 9 (2004) 3137-3144
    • (2004) Front. Biosci. , vol.9 , pp. 3137-3144
    • Jy, W.1    Minagar, A.2    Jimenez, J.J.3    Sheremata, W.A.4    Mauro, L.M.5    Horstman, L.L.6    Bidot, C.7    Ahn, Y.S.8
  • 21
    • 0033667644 scopus 로고    scopus 로고
    • Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against mucosal addressin cell adhesion molecule-1, given early in the course of disease progression
    • Kanwar J.R., Kanwar R.K., Wang D., and Krissansen G.W. Prevention of a chronic progressive form of experimental autoimmune encephalomyelitis by an antibody against mucosal addressin cell adhesion molecule-1, given early in the course of disease progression. Immunol. Cell Biol. 78 (2000) 641-645
    • (2000) Immunol. Cell Biol. , vol.78 , pp. 641-645
    • Kanwar, J.R.1    Kanwar, R.K.2    Wang, D.3    Krissansen, G.W.4
  • 23
    • 33644948466 scopus 로고    scopus 로고
    • Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice
    • Kort J.J., Kawamura K., Fugger L., Weissert R., and Forsthuber T.G. Efficient presentation of myelin oligodendrocyte glycoprotein peptides but not protein by astrocytes from HLA-DR2 and HLA-DR4 transgenic mice. J. Neuroimmunol. 173 (2006) 23-34
    • (2006) J. Neuroimmunol. , vol.173 , pp. 23-34
    • Kort, J.J.1    Kawamura, K.2    Fugger, L.3    Weissert, R.4    Forsthuber, T.G.5
  • 24
    • 0036933774 scopus 로고    scopus 로고
    • Antegren (natalizumab). A promising new approach to therapy of multiple sclerosis
    • Kumpfel T., Heydari N., and Hohlfeld R. Antegren (natalizumab). A promising new approach to therapy of multiple sclerosis. Nervenarzt 73 (2002) 552-555
    • (2002) Nervenarzt , vol.73 , pp. 552-555
    • Kumpfel, T.1    Heydari, N.2    Hohlfeld, R.3
  • 25
    • 0033622322 scopus 로고    scopus 로고
    • Interaction of α4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro
    • Laschinger M., and Engelhardt B. Interaction of α4-integrin with VCAM-1 is involved in adhesion of encephalitogenic T cell blasts to brain endothelium but not in their transendothelial migration in vitro. J. Neuroimmunol. 102 (2000) 32-43
    • (2000) J. Neuroimmunol. , vol.102 , pp. 32-43
    • Laschinger, M.1    Engelhardt, B.2
  • 26
    • 0036914616 scopus 로고    scopus 로고
    • Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo
    • Laschinger M., Vajkoczy P., and Engelhardt B. Encephalitogenic T cells use LFA-1 for transendothelial migration but not during capture and initial adhesion strengthening in healthy spinal cord microvessels in vivo. Eur. J. Immunol. 32 (2002) 3598-3606
    • (2002) Eur. J. Immunol. , vol.32 , pp. 3598-3606
    • Laschinger, M.1    Vajkoczy, P.2    Engelhardt, B.3
  • 27
    • 0024361040 scopus 로고
    • Sites of egress of inflammatory cells and horseradish peroxidase transport across the blood-brain barrier in a murine model of chronic relapsing experimental allergic encephalomyelitis
    • Lossinsky A.S., Badmajew V., Robson J.A., Moretz R.C., and Wisniewski H.M. Sites of egress of inflammatory cells and horseradish peroxidase transport across the blood-brain barrier in a murine model of chronic relapsing experimental allergic encephalomyelitis. Acta Neuropathol. (Berl.) 78 (1989) 359-371
    • (1989) Acta Neuropathol. (Berl.) , vol.78 , pp. 359-371
    • Lossinsky, A.S.1    Badmajew, V.2    Robson, J.A.3    Moretz, R.C.4    Wisniewski, H.M.5
  • 28
    • 0032705907 scopus 로고    scopus 로고
    • Increased serum levels of soluble PECAM-1 in multiple sclerosis patients with brain gadolinium-enhancing lesions
    • Losy J., Niezgoda A., and Wender M. Increased serum levels of soluble PECAM-1 in multiple sclerosis patients with brain gadolinium-enhancing lesions. J. Neuroimmunol. 99 (1999) 169-172
    • (1999) J. Neuroimmunol. , vol.99 , pp. 169-172
    • Losy, J.1    Niezgoda, A.2    Wender, M.3
  • 29
    • 33745070072 scopus 로고    scopus 로고
    • Epstein-Barr virus and multiple sclerosis
    • Lovett-Racke A.E., and Racke M.K. Epstein-Barr virus and multiple sclerosis. Arch. Neurol. 63 (2006) 810-811
    • (2006) Arch. Neurol. , vol.63 , pp. 810-811
    • Lovett-Racke, A.E.1    Racke, M.K.2
  • 30
    • 0342906187 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination
    • Lucchinetti C., Bruck W., Parisi J., Scheithauer B., Rodriguez M., and Lassmann H. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann. Neurol. 47 (2000) 707-717
    • (2000) Ann. Neurol. , vol.47 , pp. 707-717
    • Lucchinetti, C.1    Bruck, W.2    Parisi, J.3    Scheithauer, B.4    Rodriguez, M.5    Lassmann, H.6
  • 31
    • 0242494863 scopus 로고    scopus 로고
    • T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: The cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells
    • Lyck R., Reiss Y., Gerwin N., Greenwood J., Adamson P., and Engelhardt B. T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: The cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. Blood 102 (2003) 3675-3683
    • (2003) Blood , vol.102 , pp. 3675-3683
    • Lyck, R.1    Reiss, Y.2    Gerwin, N.3    Greenwood, J.4    Adamson, P.5    Engelhardt, B.6
  • 33
    • 0026716479 scopus 로고
    • Ultrastructural pathology of experimental autoimmune uveitis. Quantitative evidence of activation and possible high endothelial venule-like changes in retinal vascular endothelium
    • McMenamin P.G., Forrester J.V., Steptoe R.J., and Dua H.S. Ultrastructural pathology of experimental autoimmune uveitis. Quantitative evidence of activation and possible high endothelial venule-like changes in retinal vascular endothelium. Lab. Invest. 67 (1992) 42-55
    • (1992) Lab. Invest. , vol.67 , pp. 42-55
    • McMenamin, P.G.1    Forrester, J.V.2    Steptoe, R.J.3    Dua, H.S.4
  • 35
    • 0344961161 scopus 로고    scopus 로고
    • Blood-brain barrier disruption in multiple sclerosis
    • Minagar A., and Alexander J.S. Blood-brain barrier disruption in multiple sclerosis. Mult. Scler. 9 (2003) 540-549
    • (2003) Mult. Scler. , vol.9 , pp. 540-549
    • Minagar, A.1    Alexander, J.S.2
  • 37
    • 0038660123 scopus 로고    scopus 로고
    • Serum from patients with multiple sclerosis downregulates occludin and VE-cadherin expression in cultured endothelial cells
    • Minagar A., Ostanin D., Long A.C., Jennings M., Kelley R.E., Sasaki M., and Alexander J.S. Serum from patients with multiple sclerosis downregulates occludin and VE-cadherin expression in cultured endothelial cells. Mult. Scler. 9 3 (2003) 235-238
    • (2003) Mult. Scler. , vol.9 , Issue.3 , pp. 235-238
    • Minagar, A.1    Ostanin, D.2    Long, A.C.3    Jennings, M.4    Kelley, R.E.5    Sasaki, M.6    Alexander, J.S.7
  • 40
    • 23044481655 scopus 로고    scopus 로고
    • PSGL-1 is not required for development of experimental autoimmune encephalomyelitis
    • Osmers I., Bullard D.C., and Barnum S.R. PSGL-1 is not required for development of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 166 (2005) 193-196
    • (2005) J. Neuroimmunol. , vol.166 , pp. 193-196
    • Osmers, I.1    Bullard, D.C.2    Barnum, S.R.3
  • 41
    • 0036211141 scopus 로고    scopus 로고
    • Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis
    • Plumb J., McQuaid S., Mirakhur M., and Kirk J. Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol. 12 (2002) 154-169
    • (2002) Brain Pathol. , vol.12 , pp. 154-169
    • Plumb, J.1    McQuaid, S.2    Mirakhur, M.3    Kirk, J.4
  • 43
    • 0025168906 scopus 로고
    • Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination
    • Raine C.S., Cannella B., Duijvestijn A.M., and Cross A.H. Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab. Invest. 63 (1990) 476-489
    • (1990) Lab. Invest. , vol.63 , pp. 476-489
    • Raine, C.S.1    Cannella, B.2    Duijvestijn, A.M.3    Cross, A.H.4
  • 44
    • 2142760850 scopus 로고    scopus 로고
    • CYP450 dietary inhibitors attenuate TNF-alpha-stimulated endothelial molecule expression and leukocyte adhesion
    • Sasaki M., Elrod J.W., Jordan P., Itoh M., Joh T., Minagar A., and Alexander J.S. CYP450 dietary inhibitors attenuate TNF-alpha-stimulated endothelial molecule expression and leukocyte adhesion. Am. J. Physiol. Cell Physiol. 286 (2004) 931-939
    • (2004) Am. J. Physiol. Cell Physiol. , vol.286 , pp. 931-939
    • Sasaki, M.1    Elrod, J.W.2    Jordan, P.3    Itoh, M.4    Joh, T.5    Minagar, A.6    Alexander, J.S.7
  • 45
    • 15244349695 scopus 로고    scopus 로고
    • Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha
    • Sasaki M., Jordan P., Welbourne T., Minagar A., Joh T., Itoh M., Elrod J.W., and Alexander J.S. Troglitazone, a PPAR-gamma activator prevents endothelial cell adhesion molecule expression and lymphocyte adhesion mediated by TNF-alpha. BMC Physiol. 5 1 (2005) 3
    • (2005) BMC Physiol. , vol.5 , Issue.1 , pp. 3
    • Sasaki, M.1    Jordan, P.2    Welbourne, T.3    Minagar, A.4    Joh, T.5    Itoh, M.6    Elrod, J.W.7    Alexander, J.S.8
  • 46
    • 0036167093 scopus 로고    scopus 로고
    • CD99 plays a major role in the migration of monocytes through endothelial junctions
    • Schenkel A.R., Mamdouh Z., Chen X., Liebman R.M., and Muller W.A. CD99 plays a major role in the migration of monocytes through endothelial junctions. Nat. Immunol. 3 (2002) 143-150
    • (2002) Nat. Immunol. , vol.3 , pp. 143-150
    • Schenkel, A.R.1    Mamdouh, Z.2    Chen, X.3    Liebman, R.M.4    Muller, W.A.5
  • 47
    • 0037385335 scopus 로고    scopus 로고
    • Regulation and functional effects of monocyte migration across human brain-derived endothelial cells
    • Seguin R., Biernacki K., Rotondo R.L., Prat A., and Antel J.P. Regulation and functional effects of monocyte migration across human brain-derived endothelial cells. J. Neuropathol. Exp. Neurol. 62 (2003) 412-419
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 412-419
    • Seguin, R.1    Biernacki, K.2    Rotondo, R.L.3    Prat, A.4    Antel, J.P.5
  • 48
    • 33749383260 scopus 로고    scopus 로고
    • Interferon-beta1a reduces plasma CD31+ endothelial microparticles (CD31 + EMP) in multiple sclerosis
    • Sheremata W.A., Jy W., Delgado S., Minagar A., McLarty J., and Ahn Y. Interferon-beta1a reduces plasma CD31+ endothelial microparticles (CD31 + EMP) in multiple sclerosis. J. Neuroinflammation 3 (2006) 23
    • (2006) J. Neuroinflammation , vol.3 , pp. 23
    • Sheremata, W.A.1    Jy, W.2    Delgado, S.3    Minagar, A.4    McLarty, J.5    Ahn, Y.6
  • 49
    • 0027371220 scopus 로고
    • The Peyer's patch high endothelial receptor for lymphocytes, the mucosal vascular addressin, is induced on a murine endothelial cell line by tumor necrosis factor-alpha and IL-1
    • Sikorski E.E., Hallmann R., Berg E.L., and Butcher E.C. The Peyer's patch high endothelial receptor for lymphocytes, the mucosal vascular addressin, is induced on a murine endothelial cell line by tumor necrosis factor-alpha and IL-1. J. Immunol. 151 10 (1993) 5239-5250
    • (1993) J. Immunol. , vol.151 , Issue.10 , pp. 5239-5250
    • Sikorski, E.E.1    Hallmann, R.2    Berg, E.L.3    Butcher, E.C.4
  • 50
    • 0028283232 scopus 로고
    • Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
    • Steffen B.J., Butcher E.C., and Engelhardt B. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am. J. Pathol. 145 (1994) 189-201
    • (1994) Am. J. Pathol. , vol.145 , pp. 189-201
    • Steffen, B.J.1    Butcher, E.C.2    Engelhardt, B.3
  • 51
    • 33745728404 scopus 로고    scopus 로고
    • How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis
    • Steinman L., and Zamvil S.S. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann. Neurol. 60 (2006) 12-21
    • (2006) Ann. Neurol. , vol.60 , pp. 12-21
    • Steinman, L.1    Zamvil, S.S.2
  • 52
    • 0025717370 scopus 로고
    • Interaction of T lymphocytes with cerebral endothelial cells in vitro
    • Wekerle H., Engelhardt B., Risau W., and Meyermann R. Interaction of T lymphocytes with cerebral endothelial cells in vitro. Brain. Pathol. 1 (1991) 107-114
    • (1991) Brain. Pathol. , vol.1 , pp. 107-114
    • Wekerle, H.1    Engelhardt, B.2    Risau, W.3    Meyermann, R.4
  • 53
    • 16344368162 scopus 로고    scopus 로고
    • Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact
    • Wolburg H., Wolburg-Buchholz K., and Engelhardt B. Diapedesis of mononuclear cells across cerebral venules during experimental autoimmune encephalomyelitis leaves tight junctions intact. Acta Neuropathol. (Berl.) 109 (2005) 181-190
    • (2005) Acta Neuropathol. (Berl.) , vol.109 , pp. 181-190
    • Wolburg, H.1    Wolburg-Buchholz, K.2    Engelhardt, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.