Antegren (Natalizumab): A new therapeutic approach for the treatment of multiple sclerosis;Antegren (Natalizumab): Ein viel versprechender neuer ansatz für die therapie der multiplen sklerose

Nervenarzt

Volumn 73, Issue 6, 2002, Pages 552-555

  Kumpfel T ^a   Heydari, N ^a   Hohlfeld, R ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Antegren (Natalizumab); MS therapy; Relapsing remitting MS

Indexed keywords

ALPHA4 INTEGRIN; BETA1 INTEGRIN; BETA7 INTEGRIN; CELL ADHESION MOLECULE; INTEGRIN; MONOCLONAL ANTIBODY; NATALIZUMAB; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN INJURY; DIAGNOSTIC IMAGING; DRUG BINDING; DRUG SAFETY; DRUG TOLERABILITY; EXTRACELLULAR MATRIX; HUMAN; LEUKOCYTE; MOLECULAR INTERACTION; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; SHORT COURSE THERAPY;

ANIMALS; ANTIBODIES, MONOCLONAL; CLINICAL TRIALS; HUMANS; INTEGRIN ALPHA4BETA1; INTEGRINS; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; NEUROLOGIC EXAMINATION; TREATMENT OUTCOME;

EID: 0036933774     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00115-002-1314-3     Document Type: Article

References (18)

1. Alon R, Kassner PD, Carr MW, Finger EB, Hemler ME, Springer TA (1995) The integrin VLA-4 supports tethering and rolling in flow on VCAM-1.J Cell Biol 128:1243-1253
2. Archelos JJ, Previtali SC, Hartung H-P (1999) The role of integrins in immune-mediated diseases of the nervous system. Trends Neurosci 22:30-38
3. Chabas D, Baranzini SE, Mitchell D et al.(2001) The influence of the proinflammatory cytokine, Ostepontin, on autoimmune demyelinating disease. Science 294:731-1735.
4. Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS (2001) Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest 107:1055-61
5. Engelhardt B, Laschinger M, Schulz M, Samulowitz U, Vestweber D, Hoch G (1998) The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin. J Clin Invest 102:2096-105
6. Gao JX, Issekutz AC (1997) The beta 1 integrin, very late activation antigen-4 on human neutrophils can contribute to neutrophil migration through connective tissue fibroblast barriers. Immunology 90:448-54
7. Graesser D, Mahooti S, Madri JA (2000) Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitis. J Neuroimmunol. 109:121-31
8. Hartung H-P, Archelos JJ Zielasek J, Gold R, Koltzenburg M, Reiners K-H, Toyka KV (1995) Circulating adhesion molecule and inflammatory mediators in demyelination: a review. Neurology 45:22-32
9. Hohlfeld R (1997) Biotechnological agents for the immunotherapy of multiple sclerosis: Principles, problems and perspectives. Brain 120:865-916
10. Keszthelyi E, Karlik S, Hyduk S, Rice GP, Gordon G, Yednock T, Homer H (1996) Evidence for a prolonged role of alpha 4 integrin throughout active experimental allergic encephalomyelitis. Neurology 47:053-9
11. Kent SJ, Karlik SJ, Cannon C, Hines DK, Yednock TA, Fritz LC, Horner HC (1995) A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis. J Neuroimmunol 58:1-10
12. Lublin FD, Reingold SC (2001) Placebo-controlled clinical trials in multiple sclerosis: ethical considerations. National Multiple Sclerosis Society (USA) Task Force on Placebo-Controlled Clinical Trials in MS. Ann Neurol 49:558-560
13. Sheremata WA, Vollmer TL, Stone LA, Willmer-Hulme AJ, Koller M (1999) A safety and pharmacokinetic study of intravenous natalizumab in patients with MS. Neurology 52:072-4
14. Steffen BJ, Butcher EC, Engelhardt B (1994) Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. AM J Pathol 145:189-201
15. Tubridy N, Behan PO, Capildeo R et al. (1999) The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group. Neurology 53:444-5
16. 4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J Clin Invest 108:557-565
17. von Andrian UH, Mackay CR (2000) T-cell function and migration. Two sides of the same coin. N Engl J Med 343:1020-34
18. 1-integrin. Nature 356:63-66