Enantioselective synthesis of α-aminopropargylphosphonates

Tetrahedron Letters

Volumn 48, Issue 25, 2007, Pages 4339-4342

  Dodda, Rajasekhar ^a   Zhao, Cong Gui ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

Alkyne; Aminopropargylphosphonate; Copper(I) triflate; Enantioselective; Iminophosphonate; Phosphonate; Pybox

Indexed keywords

ALPHA AMINOPROPARGYLPHOSPHONIC ACID DERIVATIVE; COPPER; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ALKYNYLATION; ARTICLE; CATALYST; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY;

EID: 34248635392     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.04.124     Document Type: Article

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60. 3 (0.5 mL) was added while vigorous stirring, followed immediately by the terminal alkyne (1.5 mmol). The mixture was further stirred for 10 h at room temperature. After removing the solvent, the crude product was subjected to flash column chromatography (silica gel, 6:4 hexane/EtOAc) for purification, which gives the desired products as pure compounds (for NMR spectroscopic data of the products, see Ref. 10).