Enantioselective one-pot three-component synthesis of propargylamines

Organic Letters

Volumn 8, Issue 11, 2006, Pages 2405-2408

  Bisai, Alakesh ^a   Singh, Vinod K ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33745697773     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol060793f     Document Type: Article

References (40)

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40. 6 (0.010 mmol, 5 mol %) in dry chloroform (2 mL) was stirred at room temperature for 30 min. An aldehyde (0.20 mmol) and an aromatic amine (0.20 mmol) were added, and the whole mixture was stirred for an additional 15 min at the same temperature. The reaction mixture was cooled to 0 °C, and an alkyne (0.30 mmol) was added. The reaction mixture was allowed to warm to 20-25 °C. After completion of the reaction (monitoring by TLC), the mixture was concentrated in vacuo and purified over silica gel by column chromatography (2-10% EtOAc in hexane) yielding pure propargylamine.