The peroxisome proliferator-activated receptor gamma coactivator-1 alpha gene (PGC-1α) is not associated with type 2 diabetes mellitus or body mass index among hispanic and non hispanic whites from Colorado

Experimental and Clinical Endocrinology and Diabetes

Volumn 115, Issue 4, 2007, Pages 268-275

  Nelson, T L ^a,b   Fingerlin, T E ^b   Moss, L ^b   Barmada, M M ^c   Ferrell, R E ^c   Norris, J M ^b  

^a Department of Ecosystem Science and Sustainability   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Gene environment interaction; Hispanic; Type 2 diabetes

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET; DIETARY INTAKE; DNA POLYMORPHISM; FEMALE; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT ASSESSMENT; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RACE DIFFERENCE; SELF REPORT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AMINO ACID SUBSTITUTION; BODY MASS INDEX; COLORADO; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HEAT-SHOCK PROTEINS; HISPANIC AMERICANS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; TRANSCRIPTION FACTORS;

EID: 34248589346     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-960495     Document Type: Article

References (50)

1. Andruliontye L, Zacharova J, Chiasson JL, Laasko M, STOP-NIDDM Study Group. Common polymorphisms of the PPAR-gamma2 (Pro12Ala) and PGC-1alpha (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial. Diabetologia 2004; 47 (12):2176-2184
2. Auwerx J. PPAR gamma, the ultimate thrifty gene. Diabetologia 1999; 42: 1033-1049
3. Baar K. Involvement of PPAR gamma co-activator-1, nuclear respiratory factors 1 and 2, and PPAR alpha in the adaptive response to endurance exercise. Proc Nutr Soc 2004; 63 (2):269-273
4. Barroso I, Luan J, Sandhu MS, Franks PW, Crowley V, Schafer AJ, O'Rahilly S, Wareham NJ. Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes. Diabetologia 2006; 49 (3):501-505
5. Bartsocas CS, Leslie RD. Genetics of diabetes mellitus. Am J Med Genet 2002; 115(1):1-3
6. Block G, Hartman AM, Dresser CM, Carroll MD, Gannon J, Gardner L. A data-based approach to diet questionnaire design and testing. Am J Epidemiol 1986; 124: 453-469
7. Block G, Woods M, Potosky A, Clifford D. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol 1990; 43: 1327-1335
8. Bray GA, Bouchard C, James WPT (Eds.) Handbook of Obesity. New York: Marcel Dekker, 1998
9. CDC Centers for Disease Control and Prevention, National Diabetes Surveillance System. National Center for Chronic Disease Prevention and Health Promotion, Division of Adult and Community Health, data from the Behavioral Risk Factor Surveillance System. 2004
10. Cole SA, Mitchell BD, Hsueh WC, Pineda P, Beamer PA, Shuldiner AR, Comuzzie AG, Blangero J, Hixson JE. The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-g2) is associated with measures of obesity in Mexican Americans. In J of Obes 2000; 24: 522-524
11. Coulter AA, Beardon CM, Liu X, Koza RA, Kozak LP. Dietary fat interacts with QTLs controlling induction of PGC-1 alpha and UCP1 during conversion of white to brown fat. Physiol Genomics 2003; 14 (2):139-147
12. Damcott CM, Moffett SP, Feingold E, Barmada MM, Marshal JA, Hamman RF, Ferrell RE. Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator-activated receptor gamma interactively influence insulin sensitivity and body composition in males. Metabolism 2004; 53 (3):303-309
13. Deeb S, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J, Laakso M, Fujimoto W, Auwerx J. A Pro12Ala substitution in PPARg2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nature Gen 1998; 20: 284-287
14. Doucet E, Almeras N, White MD, Despres JP, Bouchard C, Tremblay A. Dietary fat composition and human adiposity. Eur J Clin Nutr 1998; 52: 2-6
15. Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O. Mutation analysis of peroxisome proliferator- activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to type II diabetes mellitus. Diabetologia 2001; 44: 2220-2226
16. Ek J, Anderson G, Urhammer SA, Hansen L, Carstensen B, Borch-Johnsen K, Drivsholm T, Berglund L, Hansen T, Lithell H, Pedersen O. Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) gene in relation to insulin sensitivity among glucose tolerant Caucasians. Diabetologia 2001; 44: 1170-1176
17. Elbein SC. The genetics of human non-insulin-dependent (type 2) diabetes mellitus. J Nutr 1997; 127: 1891S-1896S
18. Esterbauer H, Oberkofler H, Linnemayr V, Iglseder B, Hedegger M, Wolfsgruber P, Paulweber B, Fastner B, Krempler F, Putsch W. Peroxisome proliferator-activated receptor-γ coactivator-1 gene locus: Associations with obesity indices in middle-aged women. Diabetes 2002; 51: 1281-1286
19. Evans D, de Heer J, Hagemann C, Wendt D, Wolf A, Beisiegel U, Mann WA. Association between the P12A and c1431t polymorphisms in the peroxisome proliferator activated-receptor gamma (PPARgamma) gene and type 2 diabetes. Exp Clin Endocrinol Diabetes 2001; 109: 151-154
20. Franks PW, Luan J, Browne PO, Harding AH, Rahilly SO, Chatterjee VKK, Wareham NJ. Does peroxisome proliferator-activated receptor g genotype (Pro12Ala) modify the association of physical activity and dietary fat with fasting insulin level? Metabolism 2004; 53 (1):11-16
21. Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C, Kimura S, Kadowaki T. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia 2002; 45: 740-743
22. Hill JO, Wyatt HR. Role of physical activity in preventing and treating obesity. J Appl Physiol 2005; 99 (2):765-770
23. Horvath S, Xu X, Laird NM. The family based association test method: strategies for studying general genotype - phenotype associations. Eur J Hum Genet 2001; 9: 301-306
24. Kao WH, Coresh J, Shuldiner AR, Boerwinkle ES, Bray MS, Brancati FL. Pro12Ala of the Peroxisome Proliferator-Activated Receptor-2 Gene Is Associated With Lower Serum Insulin Levels in Non-obese African Americans. Diabetes 2003; 52: 1568-1572
25. Kliewer SA, Xu HE, Lambert MH, Willson TM. Peroxisome proliferator-activated receptors: From genes to physiology. Recent Prog Horm Res 2001; 56: 239-263
26. Kriska AM, Knowler WC, LaPorte RE, Drash AL, Wing RR, Blair SN, Bennett PH, Kuller LH. Development of a questionnaire to examine the relationship of physical activity and diabetes in Pima Indians. Diabetes Care 1990; 13: 401-411
27. Lacquemant C, Chikri M, Boutin P, Samson C, Froguel P. No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and type II diabetes in French Caucasians. Diabetologia 2002; 45: 602-603
28. Lake SL, Blacker D, Laird NM. Family-based tests of association in the presence of linkage. Am J Hum Genet 2000; 67 (6):1515-1525
29. Larrouy D, Vidal H, Andreeli F, Laville M, Langin D. Cloning and mRNA tissue distribution of human PPAR-gamma coactivator-1. In J of Obes 1999; 23: 1327-1332
30. Li S, Chen W, Srinivasan SR, Boerwinkle E, Berenson GS. The peroxisome proliferator-activated receptor -gamma 2 gene polymorphism (Pro12Ala) beneficially influences insulin resistance and its tracking from childhood to adulthood: The Bogalusa Heart Study. Diabetes 2003; 52: 1265-1269
31. Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metabolism 2005; 1: 361-370
32. Lindi VI, Uusitupa MIJ, Lindstrom J, Louheranta A, Eriksson JG, Valle TT, Hamalainen H, Ilannne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Tuomilehto J. Association of the Pro12Ala polymorphism in the PPAR-g gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes 2002; 51: 2581-2586
33. Luan J, Browne PO, Harding AH, Halsall DJ, O'Rahilly S, Krishna VK, Wareham NJ. Evidence for gene-nutrient interaction at the PPAR g locus. Diabetes 2001; 50: 686-689
34. Lynch J, Heimlich SP, Lakka TA, Kaplan GA, Cohen RD, Salonen R, Salonen JT. Moderately intense physical activities and high levels of cardiorespiratory fitness reduce the risk of non-insulin-dependent diabetes mellitus in middle-aged men. Arch Intern Med 1996; 156 (12):307-314
35. Manco M, Calvani M, Mingrone G. Effects of dietary fatty acids on insulin sensitivity and secretion. Diab Obes Metab 2004; 6 (6):402-413
36. Masud S, Ye S. Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-analysis. J Med Genet 2003; 40: 773-780
37. Mayer-Davis EJ, Vitolins MZ, Carmichael SL, Hemphill S, Tsaroucha G, Rushing J, Levin S. Validity and reproducibility of a food frequency interview in a Multi-Cultural Epidemiology Study. Ann Epidemiol 1999; 9 (5):314-324
38. Muller YL, Bogardus C, Pedersen O, Baier L. A Gly482Ser missense mutation in the peroxisome proliferator-activated receptor gamma coactivator-1 is associated with altered lipid oxidation and early insulin secretion in Pima Indians. Diabetes 2003; 52 (3):895-898
39. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63: 259-266
40. Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Lin J, Xiao JZ, Cao HB, Liu PA, Jiang XG, Jiang XY, Wang JP, Zheng H, Zhang H, Bennett PH, Howard BV. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diab Care 1997; 20 (4):537-544
41. Pihlajamaki J, Kinnunen M, Ruotsalainen E, Salmenniemi U, Vauhkonen I, Kuulasmaa T, Kainulainen S, Laakso M. Haplotypes of PPARGC1A are associated with glucose tolerance, body mass index and insulin sensitivity in offspring of patients with type 2 diabetes. Diabetologia 2005; 48 (7):1331-1334
42. Rabinowitz D, Laird N. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered 2000; 50: 211-223
43. Ridderstrale M, Johansson LE, Rastam L, Lindbland U. Increased risk of obesity associated with the variant allele of the PPARGC1A Gly482Ser polymorphism in physically inactive elderly men. Diabetologia 2006; 49: 496-500
44. Robitaille J, Despres JP, Perusse L, Vohl MC. The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Quebec Family Study. Clin Genet 2003; 63: 109-116
45. Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, Smith SR. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 2005; 54 (7):1926-1933
46. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: The insulin gene region and insulin dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516
47. Stumvoll M, Fritsche A, t'Hart LM, Machann J, Thamer C, Tschritter O, Van Haeften TW, Jacob S, Dekker JM, Maassen JA, Machicao F, Schick F, Heine RJ, Haring H. The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations. Exp Clin Endocrinol Diabetes 2004; 112: 253-257
48. Stumvoll M, Stefan N, Fritsche A, Madaus A, Tschritter O, Koch M, Machicao F, Haring H. Interaction effects between common polymorphisms in PPARgamma2 and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity. J Mol Med 2002; 80: 33-38
49. van Dam RM, Willett WC, Rimm EB, Stampfer MJ, Hu FB. Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care 2002; 25 (3):417-424
50. WHO. World Health Organization. Obesity: Preventing and managing the global epidemic. Geneva: WHO Division of Noncommunicable Diseases, 1998