Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols

Journal of Pharmacology and Experimental Therapeutics

Volumn 321, Issue 3, 2007, Pages 1069-1074

  Rüsch, Dirk ^a   Musset, Boris ^b   Wulf, Hinnerk ^a   Schuster, Anika ^a   Raines, Douglas E ^c  

^a UNIVERSITY HOSPITAL MARBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DERIVATIVE; BUTANOL; DOPAMINE; OCTANOL; SEROTONIN 3 AGONIST; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; SEROTONIN 3AB RECEPTOR; UNCLASSIFIED DRUG;

ALCOHOLISM; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EVOKED RESPONSE; NEUROMODULATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; VOLTAGE CLAMP; XENOPUS;

1-BUTANOL; 1-OCTANOL; 1-PROPANOL; ANIMALS; BINDING, COMPETITIVE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ELECTROPHYSIOLOGY; ETHANOL; FATTY ALCOHOLS; FEMALE; GENE EXPRESSION; HEXANOLS; HUMANS; ION CHANNEL GATING; OOCYTES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; RNA, MESSENGER; SEROTONIN; XENOPUS LAEVIS;

EID: 34248562922     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.118752     Document Type: Article

References (36)

1. Alhaider AA, Lei SZ, and Wilcox GL (1991) Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA. J Neurosci 11:1881-1888.
2. Alifimoff JK, Firestone LL, and Miller KW (1989) Anaesthetic potencies of primary alkanols: implications for the molecular dimensions of the anaesthetic site. Br J Pharmacol 96:9-16.
3. Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, and Kirkness EF (1999) The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature (Lond) 397:359-363.
4. Dawes MA, Johnson BA, Ma JZ, Ait-Daoud N, Thomas SE, and Cornelius JR (2005) Reductions in and relations between "craving" and drinking in a prospective, open-label trial of ondansetron in adolescents with alcohol dependence. Addict Behav 30:1630-1637.
5. Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, et al. (1999) The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit. J Biol Chem 274:30799-30810.
6. Eckenhoff RG and Johansson JS (1997) Molecular interactions between inhaled anesthetics and proteins. Pharmacol Rev 49:343-367.
7. Hanna MC, Davies PA, Hales TG, and Kirkness EF (2000) Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents. J Neurochem 75:240-247.
8. Hayrapetyan V, Jenschke M, Dillon GH, and Machu TK (2005) Co-expression of the 5-HT(3B) subunit with the 5-HT(3A) receptor reduces alcohol sensitivity. Brain Res Mol Brain Res 142:146-150.
9. Jenkins A, Franks NP, and Lieb WR (1996) Actions of general anaesthetics on 5-HT3 receptors in N1E-115 neuroblastoma cells. Br J Pharmacol 117:1507-1515.
10. Johnson BA, Ait-Daoud N, Ma JZ, and Wang Y (2003) Ondansetron reduces mood disturbance among biologically predisposed, alcohol-dependent individuals. Alcohol Clin Exp Res 27:1773-1779.
11. Johnson BA, Roache JD, Ait-Daoud N, Zanca NA, and Velazquez M (2002) Ondansetron reduces the craving of biologically predisposed alcoholics. Psychopharmacology (Berl) 160:408-413.
12. Johnson BA, Roache JD, Javors MA, DiClemente CC, Cloninger CR, Prihoda TJ, Bordnick PS, Ait-Daoud N, and Hensler J (2000) Ondansetron for reduction of drinking among biologically predisposed alcoholic patients: a randomized controlled trial. J Am Med Assoc 284:963-971.
13. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW, et al. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene (Amst) 319:137-148.
14. Koyama S, Matsumoto N, Kubo C, and Akaike N (2000) Presynaptic 5-HT3 receptormediated modulation of synaptic GABA release in the mechanically dissociated rat amygdala neurons. J Physiol (Lond) 529:373-383.
15. Lovinger DM (1991) Ethanol potentiation of 5-HT3 receptor-mediated ion current in NCB-20 neuroblastoma cells. Neurosci Lett 122:57-60.
16. Lovinger DM, Sung KW, and Zhou Q (2000) Ethanol and trichloroethanol alter gating of 5-HT3 receptor-channels in NCB-20 neuroblastoma cells. Neuropharmacology 39:561-570.
17. Lovinger DM and White G (1991) Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons. Mol Pharmacol 40:263-270.
18. Lovinger DM and Zhou Q (1993) Trichloroethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in nodose ganglion neurons from the adult rat. J Pharmacol Exp Ther 265:771-776.
19. Lovinger DM and Zhou Q (1994) Alcohols potentiate ion current mediated by recombinant 5-HT3RA receptors expressed in a mammalian cell line. Neuropharmacology 33:1567-1572.
20. Machu TK and Harris RA (1994) Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes. J Pharmacol Exp Ther 271:898-905.
21. Maricq AV, Peterson AS, Brake AJ, Myers RM, and Julius D (1991) Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science (Wash DC) 254:432-437.
22. McBride WJ, Lovinger DM, Machu T, Thielen RJ, Rodd ZA, Murphy JM, Roache JD, and Johnson BA (2004) Serotonin-3 receptors in the actions of alcohol, alcohol reinforcement, and alcoholism. Alcohol Clin Exp Res 28:257-267.
23. McMahon LL and Kauer JA (1997) Hippocampal interneurons are excited via serotonin-gated ion channels. J Neurophysiol 78:2493-2502.
24. Monk SA, Desai K, Brady CA, Williams JM, Lin L, Princivalle A, Hope AG, and Barnes NM (2001) Generation of a selective 5-HT3B subunit-recognising polyclonal antibody; identification of immunoreactive cells in rat hippocampus. Neuropharmacology 41:1013-1016.
25. Morales M and Wang SD (2002) Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system. J Neurosci 22:6732-6741.
26. Niesler B, Frank B, Kapeller J, and Rappold GA (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene (Amst) 310:101-111.
27. Puig MV, Santana N, Celada P, Mengod G, and Artigas F (2004) In vivo excitation of GABA interneurons in the medial prefrontal cortex through 5-HT3 receptors. Cereb Cortex 14:1365-1375.
28. Raines DE and Zachariah VT (2000) Isoflurane increases the apparent agonist affinity of the nicotinic acetylcholine receptor by reducing the microscopic agonist dissociation constant. Anesthesiology 92:775-785.
29. Reeves DC and Lummis SC (2006) Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies. BMC Neurosci 7:27.
30. Rüsch D, Zhong H, and Forman SA (2004) Gating allosterism at a single class of etomidate sites on α1β 2γ2L GABA A receptors accounts for both direct activation and agonist modulation. J Biol Chem 279:20982-20992.
31. Solt K, Stevens RJ, Davies PA, and Raines DE (2005) General anesthetic-induced channel gating enhancement of 5-hydroxytryptamine type 3 receptors depends on receptor subunit composition. J Pharmacol Exp Ther 315:771-776.
32. Stevens R, Rusch D, Solt K, Raines DE, and Davies PA (2005a) Modulation of human 5-hydroxytryptamine type 3AB receptors by volatile anesthetics and n-alcohols. J Pharmacol Exp Ther 314:338-345.
33. Stevens RJ, Rusch D, Davies PA, and Raines DE (2005b) Molecular properties important for inhaled anesthetic action on human 5-HT3A receptors. Anesth Analg 100:1696-1703.
34. Topf N, Jenkins A, Baron N, and Harrison NL (2003) Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists. Anesthesiology 98:306-311.
35. Wu G, Tonner PH, and Miller KW (1994) Ethanol stabilizes the open channel state of the Torpedo nicotinic acetylcholine receptor. Mol Pharmacol 45:102-108.
36. Zhou FM and Hablitz JJ (1999) Activation of serotonin receptors modulates synaptic transmission in rat cerebral cortex. J Neurophysiol 82:2989-2999.