Ethanol and trichloroethanol alter gating of 5-HT3 receptor-channels in NCB-20 neuroblastoma cells

Neuropharmacology

Volumn 39, Issue 4, 2000, Pages 561-570

  Lovinger, David M ^a   Sung, Ki Wug ^a   Zhou, Qing ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; Ligand gated ion channel; Neuroblastoma cells; Partial agonist; Serotonin

Indexed keywords

ALCOHOL; DOPAMINE; ION CHANNEL; SEROTONIN; SEROTONIN 3 RECEPTOR; TRICHLOROETHANOL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ION CURRENT; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY;

DOPAMINE; ETHANOL; ETHYLENE CHLOROHYDRIN; ION CHANNEL GATING; PATCH-CLAMP TECHNIQUES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGONISTS; TUMOR CELLS, CULTURED;

EID: 0033962681     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00164-1     Document Type: Article

References (31)

1. 14C-guanidinium influx in N1E-115 neuroblastoma cells. Naunyn-Schmiedebergs Archiv. Pharmacol. 352(2):1995;149-156.
2. 3 receptor in mammalian NG108-15 cells. J. Physiol. (London). 490:1996;679-690.
3. Colquhoun D. Binding, gating, affinity and efficacy. Br. J. Pharmacol. 125:1998;923-947.
4. Colquhoun D., Hawkes A.G. The principles of the stochastic interpretation of ion-channel mechanisms. Sakmann B., Neher E. Single-Channel Recording. 2nd ed. 1995;397-482 Plenum Press, New York.
5. 3 receptor does not eliminate its modulation by ethanol. Alc. Clin. Exper. Res. 21:1997;7A.
6. 3 receptors. Br. J. Pharmacol. 114(8):1995;1641-1651.
7. 3 receptor antagonist, suppresses voluntary ethanol consumption in alcohol-preferring rats. Alcohol and Alcoholism. 26:1991;107-110.
8. 3 receptors in drug dependence. Drug and Alcohol Dependence. 38:1995;155-171.
9. A responses in cells stably transfected with receptor subunits. Alc. Clin. Exper. Res. 19(1):1995;226-232.
10. 3 receptors in NCB-20 cells and in rat cerebral membranes. Alc. Clin. Exper. Res. 15:1991;775-778.
11. 3 receptor channel. A. Rev. Physiol. 57:1995;447-468.
12. 3 receptors in N1E-115 neuroblastoma cells. Br. J. Pharmacol. 117(7):1996;1507-1515.
13. 3 receptor blockade: a preliminary study in healthy male volunteers. Psychopharmacology. 112:1993;142-144.
14. LeMarquand D., Pihl R.O., Benkelfat C. Serotonin and alcohol intake, abuse, and dependence: clinical evidence. Biol. Psych. 36(5):1994;326-337.
15. LeMarquand D., Pihl R.O., Benkelfat C. Serotonin and alcohol intake, abuse, and dependence: findings of animal studies. Biol. Psych. 36(6):1994;395-421.
16. Liu Y., Dilger J.P., Vidal A.M. Effects of alcohols and volatile anesthetics on the activation of nicotinic acetylcholine receptor channels. Mol. Pharmacol. 45:1994;1235-1241.
17. 3 receptor-mediated ion current in NCB-20 neuroblastoma cells. Neurosci. Lett. 122:1991;54-56.
18. 3 receptor mediated ion current in neuroblastoma cells and isolated adult mammalian neurons. Mol. Pharmacol. 40:1991;263-270.
19. 3 receptor mediated ion current in nodose ganglion neurons from adult rat. J. Pharmacol. Exp. Ther. 265:1993;771-777.
20. 3RA receptors expressed in a mammalian cell line. Neuropharmacology. 33:1994;1567-1572.
21. 3 receptor. Liu Y., Hunt W.A. The "Drunken" Synapse: Studies of Alcohol-Related Disorders. 1999;51-61 Kluwer Academic/Plenum Publishers, New York.
22. 3 receptors expressed in Xenopus laevis ooctyes. J. Pharmacol. Exp. Ther. 271(2):1994;898-905.
23. 3 receptors. Eur. J. Pharmacol. 127(3):1986;271-274.
24. 3 antagonist ondansetron in alcohol abuse and dependence. Alc. Clin. Exper. Res. 18:1994;879-885.
25. 3 antagonist ondansetron on voluntary ethanol intake in rats and mice maintained on a limited access procedure. Psychopharmacology. 117(4):1995;479-485.
26. 3 receptor by full and partial agonists. Br. J. Pharmacol. 117(5):1996;839-846.
27. A receptors requires phosphorylation of the alternatively spliced variant of the gamma 2 subunit. FEBS Lett. 313(2):1992;113-117.
28. A responses in stably transfected cells. J. Neurochem. 66(3):1996;1318-1321.
29. Wu G., Tonner P.H., Miller K.W. Ethanol stabilizes the open channel state of the Torpedo nicotinic acetylcholine receptor. Mol. Pharmacol. 45:1993;102-108.
30. 3 receptors by alcohols and diethyl ether in NCB-20 neuroblastoma cells. J. Pharmacol. Exp. Ther. 278:1996;732-740.
31. 3 receptor-channels on NCB-20 neuroblastoma cells by favouring and stabilizing the open channel state. J. Physiol. (London). 507(2):1998;335-352.