Practical synthesis of enantiomerically pure β2-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes

Journal of the American Chemical Society

Volumn 129, Issue 18, 2007, Pages 6050-6055

  Chi, Yonggui ^a   English, Emily P ^a   Pomerantz, William C ^a   Horne, W Seth ^a   Joyce, Leo A ^a   Alexander, Lane R ^a   Fleming, William S ^a   Hopkins, Elizabeth A ^a   Gellman, Samuel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; CATALYSIS; COLUMN CHROMATOGRAPHY; CRYSTALLIZATION; ENANTIOMERS; METHYLATION; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

AMINO ALCOHOLS; AMINO ALDEHYDES; DIASTEREOSELECTIVE AMINOMETHYLATION;

AMINO ACIDS;

ALDEHYDE DERIVATIVE; AMINO ACID DERIVATIVE; AMINOALCOHOL; GLUTAMIC ACID DERIVATIVE; LYSINE DERIVATIVE; PEPTIDE DERIVATIVE; PROLINE; TYROSINE DERIVATIVE;

ANALYTIC METHOD; ARTICLE; CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; COLUMN CHROMATOGRAPHY; CRYSTALLIZATION; ENANTIOMER; METHYLATION; PROTEIN PURIFICATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 34248562082     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja070063i     Document Type: Article

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110. 1H NMR to monitor the reaction.
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113. Recrystallization may be necessary if the crystals contain the minor diastereomer at this point.
114. 7).